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New disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission

A technology of ethyl pyrrolidine and methyl pyrrolidine, which can be applied in nervous system diseases, active ingredients of heterocyclic compounds, organic chemistry, etc., can solve the problem of no norepinephrine and dopamine neurotransmission, etc.

Inactive Publication Date: 2010-08-18
NSAB FILIAL AF NEUROSEARCH SVERIGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Thus, there is nothing in WO 92 / 18475, WO 2005 / 121092, J. Med. Chem. 1994, 37, 2735 or Bioorg. Med. Chem. Lett. A guide to neurotransmission of norepinephrine and dopamine

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  • New disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission
  • New disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission
  • New disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission

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Abstract

The present invention relates to the use of compounds which increase extracellular levels of catecholamines, dopamine and norepinephrine, in cerebral cortical areas of the mammalian brain, and more specifically to the use of 3-disubstituted phenyl-1 - pyrrolidinols for the treatment of central nervous system disorders.

Description

technical field The present invention relates to novel disubstituted phenylpyrrolidines and the use of these compounds, and more particularly to the use of 3-disubstituted aryl-pyrrolidinols for the treatment of disorders of the central nervous system which increase the Extracellular levels of catecholamines, dopamine, and norepinephrine in cortical regions of the brain. Background technique The cerebral cortex includes several major regions involved in higher functions such as thinking, feeling, memory, and planning (Principles of Neural science, 2nd Edition, Elsevier Science Publishing co., Inc. 1985, pp. 671-687 ). The biogenic amines, namely dopamine, norepinephrine and serotonin, are important for mammalian cortical function. Elevated dopamine and norepinephrine pathways innervate the cortex. Serotonergic neurons of the central nervous system map nearly all regions of the brain, including the cerebral cortex (Fundamental Neuroscience, Academic press 1999, pp. 207-212...

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Application Information

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IPC IPC(8): C07D207/12A61K31/40A61P25/00
CPCC07D207/12A61P25/00A61P25/18A61P25/20A61P25/22A61P25/24A61P25/28A61P43/00A61K31/40
Inventor C·索尼森L·斯万森F·彼德松N·瓦特斯S·瓦特斯
Owner NSAB FILIAL AF NEUROSEARCH SVERIGE