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Application of baicalein in preparing medicaments for preventing and treating Parkinson diseases

A technology for Parkinson's disease and baicalein, which is applied in the field of preparing pharmaceutical preparations for preventing and treating Parkinson's disease, can solve problems such as toxic and side effects, disease deterioration, and inability to delay disease progression, and achieves protection of pathological changes, promotion of reversal or recovery, inhibition of effect of development

Inactive Publication Date: 2010-10-13
INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

These drugs play a role in inhibiting the symptoms of Parkinson's patients through different channels, and can significantly improve the symptoms of Parkinson's disease, but cannot delay the progress of the disease, and cannot prevent the degeneration of dopaminergic neurons, and long-term use has serious side effects, even exacerbation of the disease

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  • Application of baicalein in preparing medicaments for preventing and treating Parkinson diseases
  • Application of baicalein in preparing medicaments for preventing and treating Parkinson diseases
  • Application of baicalein in preparing medicaments for preventing and treating Parkinson diseases

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Abstract

The invention discloses application of baicalein (chemical name: 5,6,7-trihydroxyflavone) as shown in a general formula (I) in preparing medicaments for preventing and treating Parkinson diseases. The invention relates to the application of the baicalein capable of reducing the trembling frequencies and amplitudes of the Parkinson diseases and improving and treating the symptoms of the Parkinson diseases, in particular to the application of the baicalein capable of protecting dopaminergic neurons from damage so that the pathological changes and the development of the Parkinson diseases can be effectively prevented and treated; and the baicalein exerts the function of protecting the dopaminergic neurons through apoptosis resistance, inflammatory resistance and antioxidation and exerts the function of inhibiting Parkinson symptoms through the function on nervous systems.

Description

Technical field The present invention relates to the use of baicalein to prepare medicines for preventing or treating Parkinson's disease or diseases characterized by Parkinson's disease-related symptoms. It also relates to a combination of baicalein, flavonoids and other substances for preparing pharmaceutical preparations for preventing and treating Parkinson's disease, belonging to the field of pharmacy, Background technique Parkinson's disease (PD) has become the world's second most common age-related neurodegenerative disease after Alzheimer's disease. The global incidence of people over 60 years old is 1%, and the incidence increases with age. In my country, there are more than 1.7 million Parkinson's disease patients among the elderly over 55 years old. The current understanding of the main pathological features of PD is the progressive loss and death of dopaminergic neurons in the substantia nigra compact area, which reduces the release of dopamine (DA) in the substan...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P25/16A61P25/14
CPCA61K31/352
Inventor 杜冠华穆鑫何国荣李晓秀吕扬杨宁
Owner INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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