Preparation method of linarin extracts in wild chrysanthemum flowers
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A technology for extracting glycosides and extracts, which is applied in the field of extracting active ingredients of natural medicines, can solve the problems of complex organic solvents, flammability, and high cost, and achieve the effects of simple process, low price, and simple equipment
Inactive Publication Date: 2010-10-13
SHANGHAI TESHAN FOODSTUFF TECH
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Problems solved by technology
The organic solvent involved in these methods is complicated, flammable, explosive, and the cost is also higher, which is not convenient for industrialized production
At the same time, there is no research on obtaining the high content of chrysanthemum glycoside extract in the wild chrysanthemum
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Embodiment 1
[0020] Take 1kg of wild chrysanthemum medicinal material, add 10L of 70% ethanol water, heat reflux for 6 hours, concentrate the extraction solution until it has no alcohol smell, then adjust the pH value of the concentrated solution to 10, let it stand, take the supernatant to adjust the pH with acid To 8, filter the precipitate, take the supernatant and put it on the macroporous resin, elute with water first, then elute with 10% ethanol water, 30% ethanol water and 50% ethanol water respectively, and collect 50% fractions. Concentrating and drying 50% of the distillate to obtain the extract of mongoside, and the content of mongoside is more than 50%.
Embodiment 2
[0022] Take 1kg of wild chrysanthemum medicinal material, add 8L of 80% ethanol water, extract under heat reflux for 10 hours, concentrate the extraction solution until it has no alcohol smell, then adjust the pH value of the concentrated solution to 10, let it stand, take the supernatant and adjust the pH to 8. Filter the precipitate, take the supernatant and put it on the macroporous resin, elute with water first, then elute with water, 20% ethanol water, and 60% ethanol water respectively, and collect 60% fraction. Concentrate and dry 60% of the distillate to obtain the extract of mongoside, and the content of mongoside is more than 50%.
Embodiment 3
[0024] Take 1kg of wild chrysanthemum medicinal material, add 8L of 50% ethanol water, extract by percolation flow for 8 hours, concentrate the extraction solution until it has no alcohol smell, then adjust the pH value of the concentrated solution to 12, let it stand, take the supernatant and adjust it with acid pH to 7, filter the precipitate, take the supernatant on the macroporous resin, elute with water first, then elute with 20% ethanol water, 40% ethanol water and 60% ethanol water respectively, and collect 60% fraction. Concentrating 60% of the distillate and drying to obtain an extract of mongoside, and the content of mongoside is more than 60%.
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Abstract
The invention provides a method of preparing linarin extracts from wild chrysanthemum flowers. The content of linarin in the obtained extracts is more than 50 percent. The invention has the technical scheme that the method comprises the following steps: adding wild chrysanthemum flowers into ethanol water solvents; adopting hot reflux or percolation extraction; concentrating the extraction solution to a state without ethanol flavor; then, regulating the pH value of the concentrated liquid to 10; placing the liquid; taking the supernatant fluid for regulating the pH to about 7 to 8 by acid; after the precipitates are filtered, taking supernatant fluid to be treated by macroporous resin; firstly, using water for elution; then, using 10 percent to 30 percent ethanol water and 50 percent to 80 percent ethanol water for elution; collecting 50 percent to 80 percent distillates; concentrating the 50 percent to 80 percent distillates; and carrying out drying to obtain linarin extracts with the linarin content higher than 50 percent. The solvents adopted by the invention have low price and basically has no toxicity, the used resin can be reused for many times after the regeneration, and the cost is low. In addition, the method of the invention has the advantages of simple and convenient process, simple equipment and low cost, the content of the prepared linarin extracts is more than 50 percent, the industrial production can be carried out, and the expected goal of the invention is perfectly reached.
Description
Technical field: [0001] The invention relates to a method for extracting and preparing mongolin extract from wild chrysanthemum, and belongs to the field of extracting active ingredients of natural medicines. Background technique: [0002] Wild chrysanthemum is the dry flower head of Chrysanthemum indicum L. of Compositae plant. It is a commonly used Chinese medicinal material. It has the effect of clearing away heat and detoxifying. "Chinese Pharmacopoeia". [0003] Menghuaside is a kind of flavonoid glycoside compound isolated from the wild chrysanthemum, which has the active effects of treating or preventing internal bleeding, vaginal bleeding, gastrointestinal bleeding, pathological bleeding, analgesia, and anti-edema. Its structural formula is as follows: [0004] [0005] Some documents have also reported the extraction of mongoside and the preparation method of the monomer. After extracting with alcohol and water, the extract is extracted with petroleum ether, e...
Claims
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