Electrochemical method for preparing chitosan gelatin coating on titanium implant surface

A technology for titanium implant and chitosan is applied in the field of preparing chitosan gelatin coating on the surface of titanium implant, which can solve the problems of complex process, uneven coating thickness, biological toxicity of coupling agent and the like, and achieve simple preparation equipment, avoidance of biotoxicity, effect of short preparation time

Inactive Publication Date: 2010-10-20
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The solution distillation method is to put the titanium implant into the blend solution of chitosan and biological protein. After the solution volatilizes, a coating of chitosan and functional wear white is formed on the surface of the base material. The disadvantage is that it is formed on the surface of the implant. The thickness of the coating is uneven, and there are acid residues in the formed coating, which needs further alkali neutralization
The coupling agent method is to link chitosan molecules on the surface of titanium implants through silane and glutaraldehyde. The disadvantage of this method is the potential biological toxicity of the coupling agent.
Electrostatic layer-by-layer self-assembly is to use the electrostatic interaction of two polyelectrolytes with opposite charges to form a chitosan and biological protein coating on the surface of the surface-treated charged implant by layer-by-layer adsorption. The disadvantage is that the process is more complicated

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1. Prepare a gelatin shell polybran mixed solution with a concentration ratio of 1:

[0026] 1) weigh 0.6g chitosan, be dissolved in the acetic acid solution that mass percent concentration is 1%, the concentration of chitosan is 0.6%.

[0027] 2) After stirring with magnetic force until the chitosan is completely dissolved, add 0.6 g of gelatin, the concentration of gelatin being 0.6% by mass.

[0028] 3) Put the beaker containing the solution in a water bath at 60°C for 2 hours, the gelatin is completely dissolved, and stir magnetically for 24 hours.

[0029] 4) The pH value of the above mixed solution is 3.32.

[0030] 2. Electrodeposition reaction:

[0031] 1) The platinum sheet was used as the anode, the titanium implant (1.5 cm in diameter) was used as the cathode, and the gelatin-chitosan mixed solution was used as the electrodeposition solution;

[0032] 2) The anode and cathode are immersed in the electrodeposition solution, and the distance between the two ...

Embodiment 2

[0039] 1. Prepare a gelatin shell polybran mixed solution with a concentration ratio of 2:

[0040] 1) weigh 0.6g chitosan, be dissolved in the hydrochloric acid solution that mass percent concentration is 1%, the concentration of chitosan is 0.6%.

[0041] 2) After magnetically stirring until the chitosan is completely dissolved, 1.2 g of gelatin is added, and the concentration of gelatin is 0.6% by mass.

[0042] 3) Put the beaker containing the solution in a water bath at 60°C for 2 hours, the gelatin is completely dissolved, and stir magnetically for 24 hours.

[0043] 4) The pH value of the above mixed solution is 4.1.

[0044] 2. Electrodeposition reaction:

[0045] 1) The platinum sheet is used as the anode, the titanium implant is used as the cathode, and the gelatin-chitosan mixed solution is used as the electrodeposition solution;

[0046] 2) The anode and cathode are immersed in the electrodeposition solution, and the distance between the two electrodes is 5cm; ...

Embodiment 3

[0053] 1. Prepare a gelatin-shell-polybran mixed solution with a concentration ratio of 4:

[0054] 1) weigh 1g chitosan, dissolve in the hydrochloric acid solution that mass percent concentration is 1%, the concentration of chitosan is 1%.

[0055] 2) After stirring with magnetic force until the chitosan is completely dissolved, add 4 g of gelatin, the concentration of gelatin being 4% by mass.

[0056] 3) Put the beaker containing the solution in a water bath at 60°C for 2 hours, the gelatin is completely dissolved, and stir magnetically for 24 hours.

[0057] 4) The pH value of the above mixed solution is 4.5.

[0058] 2. Electrodeposition reaction:

[0059] 1) The platinum sheet is used as the anode, the titanium implant is used as the cathode, and the gelatin-chitosan mixed solution is used as the electrodeposition solution;

[0060] 2) The anode and cathode are immersed in the electrodeposition solution, and the distance between the two electrodes is 5cm;

[0061] 3)...

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Abstract

The invention discloses an electrochemical method for preparing a chitosan gelatin coating on a titanium implant surface. The method comprises the following steps of: preparing mixed electrodeposit liquid containing gelatin chitosan; immersing platinum serving as an anode and a titanium implant serving as a cathode in the electrodeposit liquid to perform an electrodeposition reaction to result in that both chitosan and gelatin in the electrodeposit liquid are deposited on a metallic titanium surface; and taking the obtained product out, clearing the solution attached to the surface and drying the surface. The prepared chitosan gelatin composite coating has the advantages of good bonding with the titanium implant, controllable gelatin content, high biological activity and availability for further loading functional biological molecules.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a method for preparing a chitosan gelatin coating on the surface of a titanium implant. Background technique [0002] At present, titanium implants based on the theory of osseointegration have been widely used in maxillofacial surgery, dental implants and artificial bone joints. However, due to the biological inertness of titanium, implantation failure will occur when the bone mass in the implanted area is insufficient, osteoporosis or acute inflammation. When an implant osseointegrates with its surrounding bone tissue, the surface properties of the implant play a key role in the process of osseointegration. Therefore, scholars have proposed many technical methods for implant surface modification, including improving the physical and chemical properties, surface morphology, and biochemical properties of the implant surface. [0003] Chitosan is the only positively charged al...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C25D9/02
Inventor 王贻宁张贞
Owner WUHAN UNIV
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