Combination therapy related to serotonin dual action compounds

A composition, hydroxytryptophan technology, applied in the direction of drug combination, organic chemistry, organic active ingredients, etc.

Inactive Publication Date: 2010-10-20
H LUNDBECK AS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A way to manage the risk of these side effects may be to lower the dose of 5-HTP

Method used

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  • Combination therapy related to serotonin dual action compounds
  • Combination therapy related to serotonin dual action compounds
  • Combination therapy related to serotonin dual action compounds

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0015] The present invention relates to serotonin reuptake inhibitors such as 2-(6-fluoro-1H-indol-3-ylsulfanyl)-benzyl]- Pharmaceutical compositions of methyl-amines.

[0016] As used herein, "serotonin reuptake inhibitor" or "SRI" refers to a drug that inhibits serotonin reabsorption in the central nervous system (CNS) mainly or in part by binding to the primary ligand binding site of the serotonin transporter. Compounds that exert their therapeutic effects.

[0017] As used herein, "allosteric modulator" shall refer to an SRI that binds to the allosteric site of the serotonin transporter (SERT). Such compounds are also known as allosteric serotonin reuptake inhibitors (ASRIs).

[0018] In one embodiment of the invention, the allosteric modulator binds to one or more allosteric sites of SERT. In another embodiment, the allosteric modulator binds to the allosteric site of SERT capable of binding 2-(6-fluoro-1H-indol-3-ylsulfanyl)-benzyl]-methyl-amine .

[0019] 5-Hydroxy...

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Abstract

The present invention relates to combination therapies and pharmaceutical compositions comprising a combination of 5-hydroxytryptophan and a serotonin reuptake inhibitor that binds to an ailosteric site of the serotonin transporter. The present invention further provides a pharmaceutical composition comprising (i) 5-hydroxytryptophan in an amount ranging from about 1 mg to about 75 mg; and (ii) a serotonin reuptake inhibitor that binds to an allosteric site of the serotonin transporter.

Description

field of invention [0001] The present invention relates to combination therapies and pharmaceutical compositions with improved efficacy comprising a combination of 5-hydroxytryptophan and a serotonin reuptake inhibitor bound to an allosteric site of a serotonin transporter. Background of the invention [0002] Various publications are cited throughout this application. The disclosures of these publications are fully incorporated by reference into this application in order to more fully describe the field to which this invention pertains. [0003] 5-Hydroxytryptophan (5-HTP) is the immediate precursor of serotonin (5-hydroxytryptamine; 5-HT). In vivo, 5-HTP is decarboxylated to produce 5-HT. The level of 5-HT in the brain depends on the level of 5-HTP in the central nervous system (CNS). Transport of 5-HTP across the blood-brain barrier does not require a transport molecule. 5-HTP has been shown clinically to increase serotonin production in the brain, so administration o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/404A61K31/405C07D209/30C07D209/20
CPCA61K31/405A61K31/404A61P25/00A61P25/22A61P25/24A61P25/30A61P3/04A61P43/00A61K2300/00
Inventor C·S·莫里洛T·D·沃林斯基
Owner H LUNDBECK AS
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