Combination therapy related to serotonin dual action compounds
A composition, hydroxytryptophan technology, applied in the direction of drug combination, organic chemistry, organic active ingredients, etc.
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[0015] The present invention relates to serotonin reuptake inhibitors such as 2-(6-fluoro-1H-indol-3-ylsulfanyl)-benzyl]- Pharmaceutical compositions of methyl-amines.
[0016] As used herein, "serotonin reuptake inhibitor" or "SRI" refers to a drug that inhibits serotonin reabsorption in the central nervous system (CNS) mainly or in part by binding to the primary ligand binding site of the serotonin transporter. Compounds that exert their therapeutic effects.
[0017] As used herein, "allosteric modulator" shall refer to an SRI that binds to the allosteric site of the serotonin transporter (SERT). Such compounds are also known as allosteric serotonin reuptake inhibitors (ASRIs).
[0018] In one embodiment of the invention, the allosteric modulator binds to one or more allosteric sites of SERT. In another embodiment, the allosteric modulator binds to the allosteric site of SERT capable of binding 2-(6-fluoro-1H-indol-3-ylsulfanyl)-benzyl]-methyl-amine .
[0019] 5-Hydroxy...
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