Supercharge Your Innovation With Domain-Expert AI Agents!

Combination therapy related to serotonin dual action compounds

A composition, hydroxytryptophan technology, applied in the direction of drug combination, organic chemistry, organic active ingredients, etc.

Inactive Publication Date: 2010-10-20
H LUNDBECK AS
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A way to manage the risk of these side effects may be to lower the dose of 5-HTP

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Combination therapy related to serotonin dual action compounds
  • Combination therapy related to serotonin dual action compounds
  • Combination therapy related to serotonin dual action compounds

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0015] The present invention relates to serotonin reuptake inhibitors such as 2-(6-fluoro-1H-indol-3-ylsulfanyl)-benzyl]- Pharmaceutical compositions of methyl-amines.

[0016] As used herein, "serotonin reuptake inhibitor" or "SRI" refers to a drug that inhibits serotonin reabsorption in the central nervous system (CNS) mainly or in part by binding to the primary ligand binding site of the serotonin transporter. Compounds that exert their therapeutic effects.

[0017] As used herein, "allosteric modulator" shall refer to an SRI that binds to the allosteric site of the serotonin transporter (SERT). Such compounds are also known as allosteric serotonin reuptake inhibitors (ASRIs).

[0018] In one embodiment of the invention, the allosteric modulator binds to one or more allosteric sites of SERT. In another embodiment, the allosteric modulator binds to the allosteric site of SERT capable of binding 2-(6-fluoro-1H-indol-3-ylsulfanyl)-benzyl]-methyl-amine .

[0019] 5-Hydroxy...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to combination therapies and pharmaceutical compositions comprising a combination of 5-hydroxytryptophan and a serotonin reuptake inhibitor that binds to an ailosteric site of the serotonin transporter. The present invention further provides a pharmaceutical composition comprising (i) 5-hydroxytryptophan in an amount ranging from about 1 mg to about 75 mg; and (ii) a serotonin reuptake inhibitor that binds to an allosteric site of the serotonin transporter.

Description

field of invention [0001] The present invention relates to combination therapies and pharmaceutical compositions with improved efficacy comprising a combination of 5-hydroxytryptophan and a serotonin reuptake inhibitor bound to an allosteric site of a serotonin transporter. Background of the invention [0002] Various publications are cited throughout this application. The disclosures of these publications are fully incorporated by reference into this application in order to more fully describe the field to which this invention pertains. [0003] 5-Hydroxytryptophan (5-HTP) is the immediate precursor of serotonin (5-hydroxytryptamine; 5-HT). In vivo, 5-HTP is decarboxylated to produce 5-HT. The level of 5-HT in the brain depends on the level of 5-HTP in the central nervous system (CNS). Transport of 5-HTP across the blood-brain barrier does not require a transport molecule. 5-HTP has been shown clinically to increase serotonin production in the brain, so administration o...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/404A61K31/405C07D209/30C07D209/20
CPCA61K31/405A61K31/404A61P25/00A61P25/22A61P25/24A61P25/30A61P3/04A61P43/00A61K2300/00
Inventor C·S·莫里洛T·D·沃林斯基
Owner H LUNDBECK AS
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com