Multi-nozzle injection device for complex organ prosoma three-dimensional controlled forming machine

Abstract

The invention relates to a multi-nozzle injection device for a complex organ prosoma three-dimensional controlled forming machine, belonging to the field of tissue engineering. The device comprises a main bracket, a movable plate, a movable plate drive mechanism and nozzle components. At least two nozzle component guided grooves are vertically arranged on the main bracket; a slide block is arranged in each nozzle component guided groove; the nozzle components are fixedly connected with the slide blocks; a horizontal movable plate channel is arranged at the lower part of the main bracket, and the channel is communicated with the nozzle component guided groove; the movable plate is arranged in the movable plate channel, and the upper plate surface is in the shape of V; and the bottom of the slide block is in contact with the V-shaped upper plate surface. The movable plate drive mechanism drives the movable plate to do horizontal reciprocating motion, and the horizontal motion of the movable plate drives the slide blocks to do vertical lifting motion, thereby realizing lifting displacement motion when switching the nozzle by the injection device, effectively avoiding the influence of a standby nozzle to a work nozzle, and realizing precise formation of heterogeneous multiple material organ prosoma with large size and complex three dimensional structure.

Description

technical field [0001] The invention belongs to the technical field of tissue engineering, and in particular relates to a multi-nozzle spraying device for a complex organ precursor three-dimensional controlled forming machine. Background technique [0002] Tissue engineering is a popular interdisciplinary subject at present. Its three major elements are cells, biomaterial scaffolds and growth factors. [0003] In terms of the forming process of porous scaffolds, the traditional forming processes include: fiber weaving method, fiber bonding method, thermally induced phase separation method, solution casting porogen leaching method, melting molding method and air pressure pore forming method, etc. These methods can all form two-dimensional or three-dimensional porous scaffolds. However, the scaffolds prepared by these processes have certain limitations, such as lack of stable structure, poor mechanical properties, or harmful chemical solvent residues. All these traditional ...

AI Technical Summary

Problems solved by technology

The disadvantage of this method is: when forming, since all nozzles are on the same plane, the standby nozzle and the working nozzle will interfere with each other; in order to avoid the influence of the standby nozzle on the forming of the working nozzle, avoid the bottom of the standby nozzle from contacting the formed support , the formed area must be smaller than the distance between the two nozzles, which makes it impossible to accumulate and form the precursors of large-volume complex organs

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