Fat soluble dual-core cobalt (III) anti-tumor coordination compound and preparation method thereof

Abstract

The invention discloses a fat soluble dual-core cobalt (III) anti-tumor coordination compound and a preparation method thereof. The fat soluble dual-core cobalt (III) anti-tumor coordination compound belongs to lipophilic cobalt anti-tumor coordination compounds. The coordination compound of the invention has a chemical name of N,N'-bis(salicylidene)diamine cobalt (III) ([Co2(C14H12N2O2)3] for short), a molecular formula of C42H33Co2N6O6 and a molecular weight FW of 834.63, and is prepared by using CoAc2.4H2O as a raw material and by the steps of performing a quantitative reaction of the CoAc2.4H2O and ligand N,N'-bis(salicylidene)diamine in a solvent of dimethyl formamide and separating out products. The anti-tumor activity of the coordination compound is 1.6 times that of cis-platinum and 5 times that of carboplatin; an anti-tumor G150 value is 0.35mu g / mL; the activity is higher than those of the cis-platinum and carboplatin; and the coordination compound is low in toxicity and high in fat solubility and is used for clinical tumor treatment.

Description

technical field [0001] The invention belongs to lipophilic cobalt anti-tumor complexes. Background technique [0002] Chemotherapy is currently one of the three major methods for humans to deal with cancer, and it is widely used clinically. The main drugs of chemotherapy are all cytotoxic compounds, which lack selectivity and specificity to cancer cells. While killing cancer cells, they also greatly damage normal tissue cells and cause serious side effects [Edited by Han Rui. Tumor Chemoprevention And Drug Treatment. Beijing Medical University, China Union Medical University Press. Beijing, 1991]. Chemotherapy is based on chemotherapeutic drugs, and countries all over the world invest a lot of manpower, material and financial resources in the research of anticancer drugs every year. [0003] Cobalt is an essential trace element in the human body, and exists in the form of complexes in living organisms. Because it can be used as an excellent probe ion to replace Zn(II), Mn...

AI Technical Summary

Problems solved by technology

However, platinum-based anticancer drugs have relatively large toxic and side effects, and cancer patients receiving treatment usually have severe toxic and side effects such as bone marrow suppression, such as thrombocytopenia, nausea and vomiting, kidney and nerve damage, so research on non-platinum-based complexes with less toxicity is still necessary. It is one of the main directions of anticancer drug research

Images