Method for producing swine fever vaccines

A live swine fever vaccine and production method technology, applied in the field of veterinary biological products, can solve the problems of exogenous virus contamination risk, high quality control difficulty, poor genetic stability of virus, etc., to improve genetic stability and biological safety , high content of active ingredients in the vaccine, stable immunogenicity of the vaccine
CN101905020BInactive Publication Date: 2012-09-05CHINA INST OF VETERINARY DRUG CONTROL
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CHINA INST OF VETERINARY DRUG CONTROL
Publication Date
2012-09-05
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a method for producing swine fever vaccines, which comprises the following technical steps: (1) cloning and identifying hog cholera lapinized virus strain; (2) propagating seed viruses of the cloned strain; (3) propagating productive cells; (4) propagating productive virus solution; and (5) distributing vaccines, filling and freeze-drying. The method of the invention has the characteristics of simple and stable production process, high virus immunogenicity and genetic stability, small exogenous virus pollution risks, convenient examination, low production cost and thelike. The swine fever vaccines produced by the method have high genetic stability, purity and immunogenicity.
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Description

technical field

[0001] The invention relates to a production method of a swine fever live vaccine and belongs to the technical field of veterinary biological products. Background technique

[0002] Classical Swine Fever (CSF) is a highly contagious and fatal swine infectious disease caused by Classical Swine Fever Virus (CSFV), which occurs in many countries and regions in the world. Industrial production has brought serious economic losses. The World Organization for Animal Health (OIE) lists swine fever as a statutory notifiable disease, and my country classifies it as a first-class animal infectious disease.

[0003] At present, there are mainly 3 kinds of live swine fever vaccines with good effects in the world, namely the GPE strain in Japan, the Thiverval strain in France and the attenuated rabbit strain (C strain) in China, among which the attenuated rabbit strain is the most widely used and is the world's leading It has made important contributions to the control a...

Claims

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