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Protecting colloid for gastroenteric mucosa

A technology for protecting glue and gastric mucosa, which is applied in the field of biomedicine, can solve the problems of treating gastrointestinal ulcers, easy to be lost, and cannot be retained on the surface of the ulcer for a long time, and achieves the effect of promoting the healing of ulcers.

Active Publication Date: 2011-01-05
北京瑞奇美德科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In addition, peptic ulcers have severe bleeding and other complications. Hemostatic agents such as thrombin and epinephrine are often sprayed under a speculum, but they are easy to lose and cannot be kept on the ulcer surface for a long time.
[0005] There are currently no products that use the purely physical principles of medical devices to treat gastrointestinal ulcers

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1. High methoxyl pectin 10g

[0028] 2. Baking soda 0.15g

[0029] 3. Calcium hydrogen phosphate 0.75 g

[0030] 4. Carboxymethylcellulose 5 grams

[0031] Packed in 1.5g packs after mixing and grinding.

Embodiment 2

[0033] 1. Low methoxyl pectin 15g

[0034] 2. Alginic acid 3 grams

[0035] 3. Potassium carbonate 0.09 g

[0036] 4. Calcium hydrogen phosphate 0.75 g

[0037] 5. Lentinan 3 grams

[0038] Two-component packaging: 1, 2, and 5 are dissolved in 900ml of water, packaged in 90ml per bottle, and sterilized at high temperature. 3 and 4 are miscible in 100ml water, packed in 10ml bottles, and sterilized at high temperature.

Embodiment 3

[0040] 1. Sodium alginate 15 grams

[0041] 2. Sodium citrate 2 grams

[0042] 3. Calcium sulfate 4 grams

[0043] 4. Carboxymethylcellulose 5 grams

[0044] Packed in 1.5g packs after mixing and grinding.

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PUM

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Abstract

The invention relates to protecting colloid for gastroenteric mucosa, belonging to the field of biomedical preparation and comprising a collagenous substance, an acidifying or alkalizing agent, a cross-linking agent and an adhesive based on the weight ratio of 1:0.01-0.3:0.1-0.5, wherein the dosage of the acidifying or alkalizing agent is proper when the pH value is regulated to 6.5-8.5. Under the action of gastric acid, the cross-linking agent in the protecting colloid can be released so as to form a colloid membrane on the surface of ulcer, avoid the gastroenteric mucosa from being digested by gastric acid and pepsase and promote healing of the ulcer. Animal tests show that the protecting colloid can greatly lower the ulcer formation caused by absolute ethyl alcohol and hydrochloric acid, inhibit ulcer formation and have a protecting effect on injury of the mice gastroenteric mucosa caused by absolute ethyl alcohol and hydrochloric acid. Therefore, the protecting colloid is used for protecting and curing gastroenteric mucosa ulcer for patients.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a preparation method and product of gastrointestinal mucosa protective glue. Background technique [0002] Ulcer disease is a common chronic systemic disease, divided into gastric ulcer and duodenal ulcer, also known as peptic ulcer. The reason why it is called peptic ulcer is that gastric ulcer and duodenal ulcer are formed due to the digestion of the mucosa itself by gastric acid and pepsin. In fact, gastric acid and pepsin are one of the main causes of ulcer formation. Therefore, the treatment of peptic ulcer is mainly to inhibit the digestion of gastric acid and pepsin on the gastrointestinal mucosa, that is, to protect the gastrointestinal mucosa, avoid the self-digestion of the mucosa, and promote the healing of the ulcer. [0003] Gastric ulcer is clinical common disease, frequently-occurring disease. There are many drugs for clinical treatment. These drugs are mainl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/70A61K31/732A61K31/734A61K47/38A61K47/36A61P1/04
Inventor 张清
Owner 北京瑞奇美德科技发展有限公司
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