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Medicinal composition for treating symptom-complex of excessive eating (diabetes) and method for preparing same

A technology of diabetes and composition, which is applied in the field of pharmaceutical composition and preparation for treating diabetes, and can solve problems such as increasing the number of insulin receptors, damaging drug resistance, increasing the binding force of insulin receptors, etc.

Inactive Publication Date: 2011-01-05
GUANGDONG JIAYING PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after long-term use of this type of drug, its hypoglycemic effect may be to increase the number of insulin receptors or increase the binding force of insulin receptors, thereby increasing the sensitivity of the surrounding tissue to insulin. The advantage of this type of drug is that it can control symptoms quickly. The curative effect is remarkable, but the side effects are obvious, especially for liver and kidney damage or long-term use of patients who are less sensitive to insulin and develop drug resistance; 2. Combination of Chinese and Western medicines. "Zhongyi Xiaoke Pill" is the representative. The main ingredients are astragalus, raw land, trichosanthin and western medicine glibenclamide. , so there is still a shortage of drug resistance in patients with liver and kidney damage

Method used

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  • Medicinal composition for treating symptom-complex of excessive eating (diabetes) and method for preparing same
  • Medicinal composition for treating symptom-complex of excessive eating (diabetes) and method for preparing same
  • Medicinal composition for treating symptom-complex of excessive eating (diabetes) and method for preparing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] 300 grams of astragalus, 100 grams of ginseng, 150 grams of kudzu root, 100 grams of schisandra

[0042] 150 grams of raw rehmannia, 150 grams of Ophiopogon japonicus, 100 grams of Coptis chinensis, 150 grams of salvia miltiorrhiza

[0043] Angelica 200g Polygonatum 200g TCS 150g Goji berries 150g

[0044] Preparation

[0045] (1) Trichosanthes powder is crushed into fine powder and passed through a 100-mesh sieve, and set aside;

[0046] (2) Coptidis Rhizoma, Schisandra, and Angelica were extracted twice with 16-4 times the amount of 50-95% ethanol under reflux, each time for 1-4 hours respectively, and the extracts were combined;

[0047] (3) Add 14-6 times the amount of water to the remaining eight flavors of ginseng, astragalus, sealwort, rehmannia root, Ophiopogon japonicus, medlar, kudzu root, and salvia miltiorrhiza, soak, heat and decoct twice, combine the decoction liquid, and add 60-95% Appropriate amount of ethanol, let it stand overnight, take the supernata...

Embodiment 2

[0049] 340 grams of astragalus, 80 grams of ginseng, 200 grams of kudzu root, 100 grams of schisandra

[0050] 100 grams of raw rehmannia, 150 grams of Ophiopogon japonicus, 80 grams of Coptis chinensis, 200 grams of salvia miltiorrhiza

[0051] Angelica 200g Polygonatum 300g TCS 150g Goji berry 150g

[0052] Preparation

[0053] (1) Trichosanthes powder is crushed into fine powder and passed through a 100-mesh sieve, and set aside;

[0054] (2) Coptidis Rhizoma, Schisandra, and Angelica were extracted twice with 16-4 times the amount of 50-95% ethanol under reflux, each time for 1-4 hours respectively, and the extracts were combined;

[0055] (3) Add 14-6 times the amount of water to the remaining eight flavors of ginseng, astragalus, sealwort, rehmannia root, Ophiopogon japonicus, medlar, kudzu root, and salvia miltiorrhiza, soak, heat and decoct twice, combine the decoction liquid, and add 60-95% Appropriate amount of ethanol, let it stand overnight, take the supernatant...

Embodiment 3

[0057] 250 grams of astragalus, 150 grams of ginseng, 250 grams of kudzu root, 150 grams of schisandra

[0058] 150 grams of raw rehmannia, 150 grams of Ophiopogon japonicus, 100 grams of Coptis chinensis, 150 grams of salvia miltiorrhiza

[0059] Angelica 200g Polygonatum 200g TCS 150g Goji berries 150g

[0060] Preparation

[0061] (1) Trichosanthes powder is crushed into fine powder and passed through a 100-mesh sieve, and set aside;

[0062] (2) Coptidis Rhizoma, Schisandra, and Angelica were extracted twice with 16-4 times the amount of 50-95% ethanol under reflux, each time for 1-4 hours respectively, and the extracts were combined;

[0063] (3) Add 14-6 times the amount of water to the remaining eight flavors of ginseng, astragalus, sealwort, rehmannia root, Ophiopogon japonicus, medlar, kudzu root, and salvia miltiorrhiza, soak, heat and decoct twice, combine the decoction liquid, and add 60-95% Appropriate amount of ethanol, let it stand overnight, take the superna...

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Abstract

Based on the main treating principle of tonifying qi and yin, nourishing spleen and tonifying kidney and promoting blood circulation and removing blood stasis, the invention provides a medicinal composition for treating symptom-complex of excessive eating (diabetes) and a method for preparing the same, and belongs to the technical field of Chinese medicinal preparations. In the method, astragalus, ginseng, manyflower solomonseal rhizome, Chinese magnoliavine fruit, fresh rehmannia, dwarf lilyturf tuber, medlar, golden thread, kudzuvine root, Chinese angelica, Mongolian snakegourd root and root of red-rooted salvia serving as raw materials undergo processes of grinding, solvent extraction, alcohol precipitation, condensation, drying, granulation and the like to form the finished product. The pharmacodynamic tests prove that by pharmacotherapeutic administration, the medicinal composition of the invention has obvious effect of reducing blood sugar of rats with tetraoxypyridine-induced hyperglycemia, mice with tetraoxypyridine-induced hyperglycemia and mice with adrenalin-induced hyperglycemia.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating diabetes (diabetes) and a preparation method, belonging to the technical field of traditional Chinese medicine preparations. It is especially suitable for clinically treating type II diabetes. Background technique [0002] Diabetes is diabetes in traditional Chinese medicine. It has a high incidence rate and a long course of disease, which can easily cause complications such as heart disease, cerebral infarction, and blindness. Modern medicine considers it to be a metabolic endocrine disease characterized by disturbances in sugar, fat, protein, and secondary water and electrolyte metabolism caused by absolute or relative insulin deficiency and reduced pancreatic function. Clinically, it is mainly characterized by persistent blood sugar elevation and urine sugar. At present, the drugs for the treatment of diabetes are divided into three categories: 1. Western medicines, such as insulin...

Claims

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Application Information

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IPC IPC(8): A61K36/8969A61P3/10
Inventor 郑沛
Owner GUANGDONG JIAYING PHARMACEUTICAL CO LTD
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