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Compound microcapsule for treating bacterial disease of livestock and poultry and preparation method thereof

A bacterial and microcapsule technology, applied in the field of veterinary medicine, can solve the problems of volatile, prone to physical and chemical reactions, poor stability, etc., and achieve the effects of regulating body functions, significant bactericidal effect, and no toxic side effects.

Inactive Publication Date: 2012-05-23
河南后羿制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is relatively volatile at room temperature, often contains a variety of unstable groups, and is prone to physical and chemical reactions, resulting in poor stability.
In order to maximize the pharmacological effects of volatile oil, it must be made into a stable dosage form through mature technology to overcome the shortcomings of its poor stability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The compound microcapsules of this embodiment for treating bacterial diseases of livestock and poultry mainly consist of the following components in parts by weight: 10 parts of oregano oil, 15 parts of levofloxacin, and 30 parts of capsule material. Wherein the capsule material adopts gelatin.

[0018] The preparation method of the compound microcapsule for the treatment of livestock and poultry bacterial diseases of the present embodiment is as follows:

[0019] 1) Take oregano oil and levofloxacin in the prescribed amount, add an aqueous solution containing 2% gelatin, mix well, and grind to make an emulsion;

[0020] 2) Add 5% acetic acid aqueous solution to the emulsion at 50°C to adjust the pH to 3.0, and stir to form a coacervate solution;

[0021] 3) Add 1 times the volume of coacervate solution in step 2) water at 35°C, stir well and cool to 5°C;

[0022] 4) After cooling, add twice the amount of 30% formaldehyde aqueous solution with a pH of 8.0, stir for 2 ...

Embodiment 2

[0024] The compound microcapsule for treating livestock and poultry bacterial diseases in this embodiment mainly consists of the following components in parts by weight: 12 parts of oregano oil, 18 parts of levofloxacin, and 50 parts of capsule material. Wherein the capsule material adopts gum arabic and gelatin in any mass ratio.

[0025] The preparation method of the compound microcapsule for the treatment of livestock and poultry bacterial diseases of the present embodiment is as follows:

[0026] 1) Take the oregano oil and levofloxacin in the prescribed amount, add a 5% aqueous solution containing gum arabic and gelatin, mix well, and grind to make an emulsion;

[0027] 2) Add 10% acetic acid aqueous solution to the emulsion at 50°C to adjust the pH to 3.5, and stir to form a coacervate solution;

[0028] 3) Add 3 times the volume of coacervate solution in step 2) water at 40°C, stir well and cool to 10°C;

[0029] 4) After cooling, add twice the amount of 35% formaldeh...

Embodiment 3

[0031] The compound microcapsule for treating livestock and poultry bacterial diseases in this embodiment mainly consists of the following components in parts by weight: 16 parts of oregano oil, 24 parts of levofloxacin, and 40 parts of capsule material. Wherein the capsule material adopts sodium carboxymethyl cellulose.

[0032] The preparation method of the compound microcapsule for the treatment of livestock and poultry bacterial diseases of the present embodiment is as follows:

[0033] 1) Take oregano oil and levofloxacin in the prescribed amount, add 10% aqueous solution containing carboxymethylcellulose sodium, mix well, and grind to make an emulsion;

[0034] 2) Add 15% acetic acid aqueous solution to the emulsion at 55°C to adjust the pH to 4.0, and stir to form a coacervate solution;

[0035] 3) Add 4 times the volume of coacervate solution in step 2) water at 40°C, stir well and cool to 5°C;

[0036] 4) After cooling, add twice the amount of 40% formaldehyde aqueo...

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Abstract

The invention discloses a compound microcapsule for treating bacterial disease of livestock and poultry and a preparation method thereof. The compound microcapsule mainly comprises the following components in part by weight: 10 to 20 parts of origano oil, 15 to 30 parts of levofloxacin and 30 to 60 parts of capsule material. The Chinese medicinal preparation origano oil is combined with the western medicine levofloxacin to prepare the compound microcapsule. The western medicine levofloxacin fast sterilizes, and the Chinese medicinal preparation origano oil assists sterilizing, and the origanooil and the levofloxacin can regulate body functions of the livestock and poultry and improves immunity at the same time. The compound microcapsule has the advantages of synergistic effects because of the combination of the Chinese medicinal preparation and the western medicine, obvious sterilizing effect, no toxic or side effect of the medicaments, and capability of treating both principal and secondary aspects of diseases. In addition, the compound microcapsule solves the problem of poor stability of the origano oil used as essential oil, and makes the origano oil easily and stably combinedwith the western medicine levofloxacin.

Description

technical field [0001] The invention relates to a compound microcapsule for treating livestock and poultry bacterial diseases and a preparation method of the microcapsule, which belongs to the technical field of veterinary medicine. Background technique [0002] Volatile oil is a kind of volatile oily component present in plants with aromatic odor, which can be distilled out with water vapor and immiscible with water. Volatile oils have a long history, and many volatile oils have strong physiological activities, especially in relieving cough and asthma, sweating, expelling wind, antibacterial and anti-inflammatory effects. However, it is relatively volatile at room temperature, often contains a variety of unstable groups, and is prone to physical and chemical reactions, resulting in poor stability. In order to make the volatile oil exert its pharmacological effect to the greatest extent, it must be made into a stable dosage form through mature technology to overcome the sho...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/53A61K9/50A61K47/36A61K47/38A61K47/42A61P31/04A61K31/5383
Inventor 吴红云李凤娟李建正
Owner 河南后羿制药有限公司
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