Compound neomycin sulfate soluble powder and production method thereof

A technology of neomycin sulfate and its production method, which is applied in powder delivery, pharmaceutical formulations, organic active ingredients, etc. It can solve the problems of short maintenance time, difficult absorption, and general curative effect, and achieves low toxicity, increased absorption, and good oral absorption. Effect

Inactive Publication Date: 2011-04-13
WUXI ZHENGDA POULTRY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, neomycin sulfate is not easy to absorb when taken orally alone, and the concentration in the intestine is high. After oral administration, only 3% of the total amount is excreted from the urine after being absorbed, and the rest is directly excreted. Therefore, the curative effect of controlling enteritis and diarrhea is general, and the maintenance time is short

Method used

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  • Compound neomycin sulfate soluble powder and production method thereof
  • Compound neomycin sulfate soluble powder and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Mix (1) 5kg of neomycin sulfate, (2) 2kg of doxycycline hydrochloride, (3) 2kg of trimethylbenzyl ammonium pyrimidine, (4) 1kg of atropine sulfate and 10kg of (7) anhydrous glucose for 5 minutes, and then Add (5) 2kg of astragalus extract, (6) 1kg of silicon dioxide fine powder and the remaining 77kg of (7) anhydrous glucose and mix for 10 minutes to obtain the final product. The content of neomycin sulfate in the final product is 5%; the pH of the aqueous solution is 4.4; the moisture content is 7.6%.

Embodiment 2

[0017] Mix (1) neomycin sulfate 8kg, (2) doxycycline hydrochloride 5kg, (3) trimethylbenzyl ammonium pyrimidine 3kg, (4) atropine sulfate 3kg and 19kg (7) anhydrous glucose for 5 minutes, then Add (5) 2kg of astragalus extract, (6) 2kg of silicon dioxide fine powder and the remaining 58kg (7) anhydrous glucose and mix for 10 minutes to obtain the final product. The content of neomycin sulfate in the final product is 8%; the pH of the aqueous solution is 4.5; the moisture content is 8.3%.

Embodiment 3

[0019] Mix (1) 10kg neomycin sulfate, (2) 8kg doxycycline hydrochloride, (3) 6kg trimethylbenzyl ammonium pyrimidine, (4) 4kg atropine sulfate and 28kg (7) anhydrous glucose for 5 minutes, then Add (5) 4kg of astragalus extract, (6) 4kg of fine silicon dioxide powder and the remaining 36kg of (7) anhydrous glucose and mix for 10 minutes to obtain the final product. The content of neomycin sulfate in the final product is 10%; the pH of the aqueous solution is 4.6; the moisture content is 8.7%.

[0020] In the above-mentioned Examples 1-3, the neomycin sulfate, doxycycline hydrochloride, trimethylbenzyl ammonium pyrimidine, atropine sulfate, astragalus extract, silicon dioxide fine powder and anhydrous glucose are all commercially available general products .

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Abstract

The invention provides compound neomycin sulfate soluble powder and a production method thereof. The soluble powder is prepared by mixing neomycin sulfate, doxycycline hydrochloride, trimethoprim, atropine sulfate, astragalus root extract, silicon dioxide fine powder and anhydrous dextrose. The obtained neomycin sulfate soluble powder is compounded by using multiple components, and has the effects of greatly reducing diarrhea of livestock and poultry animals, quickly recovering health status and the like.

Description

technical field [0001] The invention relates to the technical field of animal health medicines, in particular to a compound neomycin sulfate soluble powder and a production method thereof. Background technique [0002] The antibacterial spectrum of neomycin sulfate is similar to that of kanamycin sulfate, and it mainly acts on most Gram-negative bacilli, such as Escherichia coli, Proteus, Salmonella, and Pasteurella multocida. The curative effect on enteritis caused by the above diseases is particularly significant. Oral administration can be used to treat intestinal infections, such as chicken colibacillosis and pullorum. However, neomycin sulfate is not easy to absorb when taken orally alone, and the concentration in the intestine is high. After oral administration, only 3% of the total amount is excreted from the urine after being absorbed, and the rest is directly excreted. Therefore, the curative effect of controlling enteritis and diarrhea is general, and the maintenan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61K9/14A61K47/04A61K47/26A61P1/12A61P31/04A61K31/46A61K31/505A61K31/65A61K31/7036
Inventor 周玲
Owner WUXI ZHENGDA POULTRY
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