56 results about "Neomycin sulphate" patented technology

The present invention is directed to a composition for treating bacterial skin infections & skin inflammation, along with skin rejuvenation. More particularly, the present invention relates to a pharmaceutical cream comprising a biopolymer, a corticosteroid and an antibacterial active ingredient. It discloses a composition for treating bacterial skin infections & skin inflammation, along with skin rejuvenation containing a) a biopolymer in the form of chitosan, b) a combination of active pharmaceutical ingredients (APIs), neomycin sulphate & betamethasone valerate used in treating bacterial skin infections & skin inflammations, c) a cream base containing primary and secondary emulsifiers, waxy materials, co-solvents, acids, preservatives, buffering agents, anti oxidants, chelating agents, and humectants and d) water. The active ingredients, namely chitosan, a corticosteroid Betamethasone Valerate, and an antibacterial agent Neomycin Sulphate, are incorporated in cream base for use in treating bacterial skin infections and skin inflammation due to allergy & itching, & wounds on human skin involving contacting human skin with the above identified composition.

The invention discloses a compound neomycin sulphate solution and a preparation method thereof. The invention aims to provide a compound neomycin sulphate solution which has obvious effect on treating gastrointestinal infection of birds, treats symptoms and a root and reduces the medicine application frequency and a preparation method thereof. 100 L of solution comprises 2-15 kg of neomycin sulphate, 3-15 kg of colistin sulphate, 0.01-0.05 kg of scopolamine methobromide, 10 kg of alcohol with concentration of 95 percent and the balance of purified water. The invention adopts the neomycin sulphate and the colistin sulphate as antibacterial components, has double effects, can effectively reduce the medicine resistant rate of bacteria and has effect on common Gram negative bacteria causing intestinal infection; and the scopolamine methobromide inhibits glandular secretion, dries intestinal contents and lightens a dehydration symptom so as to have a rapid therapeutic effect.

A clean production method for neomycin sulfate fermentation includes the following steps: step 1, preparing slant spore suspension liquid; step 2, preparing seed liquid; step 3, supplementing a supplementary culture medium and ammonium sulfate in a fermenting process to enable the accumulation amount of neomycin to reach a fermentation endpoint, and stopping fermentation to obtain fermenting liquid, wherein a fermentation basal culture medium comprises 2-10% (W / V) of maltodextrin and does not contain rice flour, starch and alpha-amylase, and the supplementary culture medium comprises 20-45% (W / V) of the maltodextrin and does not contain the rice flour, the starch and the alpha-amylase; step 4, pouring the fermenting liquid into an adsorption tank, and adding resin to adsorb the neomycin toobtain the finished neomycin sulfate. The clean production method for neomycin sulfate fermentation has the advantages that the problems of large pollution and high energy consumption can be solved,the utilization rate of high-carbon-source substances can be increased, and clean production can be realized.

The invention discloses a compound florfenicol preparation for aquatic products and a preparation method and application thereof. The compound florfenicol preparation for the aquatic products consists of the following components in percentage by mass: 5 to 20 percent of florfenicol, 1 to 25 percent of neomycin sulfate and the balance of glucose. The florfenicol and the neomycin sulfate are combined, so that the antibacterial effect of the compound florfenicol preparation for the aquatic products can be improved, the prevention and treatment effects of the compound florfenicol preparation on the bacterial diseases of the aquatic products are effectively improved, and medicine consumption and cost are reduced; and the preparation method of the compound florfenicol preparation for the aquatic products is simple and practicable and greatly improves bioavailability, and the preparation has high solubility.

The invention discloses a preserved diluent of cranoglanis bouderius seminal fluid and a cryopreservation method of the cranoglanis bouderius seminal fluid. The preserved diluent is prepared from sugar, sodium salt, potassium salt, calcium salt, tyrosine, glycine, distilled water and an anti-freezing agent-dimethyl sulfoxide. The cryopreservation method comprises the following steps: selecting good male parent fish meeting the conditions to carry out seminal fluid collection, preserving in the preserved diluent in which neomycin sulfate and streptomycin are added, adopting a cooling rate which is -10.5 DEG C / 30 seconds, and putting the seminal fluid in liquid nitrogen for cryopreservation after reaching -150 DEG C; when unfreezing and recovering are needed, taking out the cyropreserved cranoglanis bouderius seminal fluid, adding a PBS (Phosphate Buffer Solution) of which the volume percentage is 0.65 to 0.7 percent as an unfreezing solution, and putting the cranoglanis bouderius seminal fluid in a water bath of which the temperature is 32 to 40 DEG C for rapid unfreezing and recovering. According to the technology disclosed by the invention, the durability of preservation time of the cranoglanis bouderius seminal fluid can be ensured, the protection effect of the seminal fluid is good, and sperms after preservation are high in survival rate and good in vitality.

The invention provides a treatment method for neomycin sulfate production wastewater. The neomycin sulfate production wastewater after pretreatment in a production workshop is mainly divided into two types of wastewater: fermentation wastewater and extraction wastewater. After the fermentation wastewater passes through the ammonia distillation reactor to remove most of the ammonia, the advanced oxidation is used to reduce the titer of neomycin sulfate remaining in the wastewater, thereby reducing the inhibitory effect of the residual titer in the wastewater on the biochemical treatment, and the fermentation after the titer is removed The wastewater is treated with anaerobic biochemical treatment. After the anaerobic biochemical treatment, the fermentation wastewater and the extraction wastewater are mixed together and then subjected to two-stage A / O aerobic biochemical treatment and advanced treatment. Finally, the stable and efficient removal of various pollutants in the wastewater is achieved, and the effluent reaches "Water Pollutant Discharge Standards for Fermentation Pharmaceutical Industry" (GB21903-2008) Table 2 standard; this method adopts the classified collection and qualitative treatment of neomycin sulfate production wastewater; it has the advantages of reasonable process economy, high treatment efficiency, low treatment cost, Stable and reliable operation and other advantages.

The invention belongs to the technical field of cultivation of alcidodes juglans chao larva, and discloses a preparation method, a cultivation method and application of an alcidodes juglans chao larvafeed. The alcidodes juglans chao larva feed is prepared from 45-50g of mouse feed, 45-50g of protein powder, 25-35g of cellulose powder, 15-20g of yeast powder, 15-20g of agar powder, 8-15g of sucrose, 1.8-2.5g of methyl p-hydroxybenzoate, 0.4-0.8g of chloramphenicol, 0.4-0.8g of neomycin sulfate, 0.8-1.5g of vitamin C, 0.8-1.5g of choline chloride, 8-15g of oat powder, 5-10g of glucose, 5-10g ofcorn flour and 750-1000ml of distilled water. The alcidodes juglans chao larva feed is prepared by uniformly mixing the mouse feed, the protein powder, the oat powder, the corn flour, the agar powderand the like; and the feed is simple in preparation process and low in cost, and is beneficial to industrialization, standardization and standardization of alcidodes juglans chao breeding.

The invention belongs to the field of chemical detection, and in particular relates to an HPLC detection method for the neomycin sulfate component in Qumixin cream, including (1) chromatographic conditions and system applicability test (2) solution preparation (3) determination and other steps . The HPLC detection method of the neomycin sulfate component in Qumixin emulsifiable cream of the present invention has the advantages of simple operation, high detection efficiency, small error, strong specificity, relatively stable detection method, less affected factors, and wide applicability ; The accuracy, precision, specificity, detection limit, etc. of the method all meet the methodological verification requirements, and have strong practicability. The method is used to analyze the neomycin sulfate group in the Trimixin cream produced by various enterprises. The detection can be carried out separately, and the content of each component of neomycin sulfate can be detected quickly and accurately, which is beneficial to the determination of the samples of Trimethin cream produced by various enterprises.

The invention discloses thermo-sensitive type gel eye drops, as well as a preparation method and application thereof. The eye drops comprise prescription active ingredients, gel matrix, a preservative, a metal ion chelating agent, an isoosmotic adjusting agent and water for injection, wherein the prescription active ingredients comprise neomycin sulfate and dexamethasone sodium phosphate; the gel matrix comprises poloxamer 407 and poloxamer 188; the preservative comprises benzalkonium bromide; the metal ion chelating agent is ethylene diamine tetraacetic acid; and the isoosmotic adjusting agent is sodium chloride. Preferably, the eye drops also comprise a moisturizing agent and a bioadhesive material. The eye drops, disclosed by the invention, have the following advantages: (1) administration is facilitated, the medicine liquid has adhesion, retention and sustained release effects on the surface of retina, the administration frequency can be reduced, the medicine loss can be reduced and the compliance of a patient can be improved; (2) the eye drops are simple in preparation process, low in cost and suitable for large-scale production; and (3) the eye drops have good antibacterial and anti-inflammatory effects, low irritability and high safety.

The invention relates to a Chinese and western medicinal compound preparation for preventing and treating bullfrog streptococcus agalactiae diseases and a preparation method, and belongs to the technical field of fish medicines. The Chinese and western medicinal compound preparation is characterized by consisting of the following substances in percentage by weight: 15 to 25 percent of Chinese gall, 5 to 15 percent of common andrographis herb, 10 to 20 percent of rhubarb, 10 to 20 percent of honeysuckle flower, 5 to 15 percent of neomycin sulfate and 25 to 35 percent of starch. The Chinese andwestern medicinal compound preparation is prepared by combining the neomycin sulfate which has a treatment effect on germs and serves as a western medicine, the Chinese gall, the common andrographis herb, the rhubarb and the honeysuckle flower which serve as Chinese medicines and the starch serving as an auxiliary material, has obvious synergistic effect and high curative effect, lasting medicinal effect and low toxicity to the environment and can arouse quick response, and the tolerance is difficult to generate; and the preparation process is simple, easy to realize, safe and convenient to use, popularize and apply.