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3-[4-(benzofuran-5-yl) thiazole-2-yl]-2-methylbenzimidazole-5-formic ether and preparation method and application thereof

A technology of methylbenzimidazole and benzofuran, which is applied in the field of new compounds and their preparation, can solve the problems of preparation methods and biological activities without research and development reports

Inactive Publication Date: 2011-04-13
CHANGSHA UNIVERSITY OF SCIENCE AND TECHNOLOGY
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3-[4-(Benzofuran-5-yl)thiazol-2-yl]-2-methylbenzimidazole-5-carboxylate and its p

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  • 3-[4-(benzofuran-5-yl) thiazole-2-yl]-2-methylbenzimidazole-5-formic ether and preparation method and application thereof
  • 3-[4-(benzofuran-5-yl) thiazole-2-yl]-2-methylbenzimidazole-5-formic ether and preparation method and application thereof
  • 3-[4-(benzofuran-5-yl) thiazole-2-yl]-2-methylbenzimidazole-5-formic ether and preparation method and application thereof

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Abstract

The invention discloses 3-[4-(benzofuran-5-yl) thiazole-2-yl]-2-methylbenzimidazole-5-formic ether shown in a chemical structural formula I and a preparation method and application thereof. In the formula, R and R1 are H, C1 to C2 alkyl, and C3 to C4 straight-chain alkyl or branched-chain alkyl. The preparation method of the 3-[4-(benzofuran-5-yl) thiazole-2-yl]-2-methylbenzimidazole-5-formic ether comprises the following steps of: heating 2-bromine-1-(7-hydroxy/alkoxy-2,2-dimethyl-2,3-dihydrobenzofuran-5-yl) ethyl ketone, N-(2-acetamido-5-alkoxycarbonyl phenyl) thiourea and acetone, reacting with stirring for 2 hours, filtering, and neutralizing filter cakes by using stronger ammonia water until the filter cakes are alkaline to prepare the 3-[4-(benzofuran-5-yl) thiazole-2-yl]-2-methylbenzimidazole-5-formic ether. The 3-[4-(benzofuran-5-yl) thiazole-2-yl]-2-methylbenzimidazole-5-formic ether has high insecticidal activity, and is applied to the preparation of insecticides.

Description

technical field [0001] The present invention relates to a new class of compounds and their preparation method and application, in particular to 3-[4-(benzofuran-5-yl)thiazol-2-yl]-2-methylbenzimidazole-5-carboxylate and preparation method and application thereof. Background technique [0002] Shao Ling et al. described 4-aryl-5-triazolylthiazole-2-imine compounds, and the results of biological activity assay showed that some of the compounds had bactericidal activity against Verticillium apple (Journal of Chemistry of Universities, 2007, 28, 270 ). Michael et al. described 2-aminothiazole breast cancer drugs (Bioorg & Med. Chem. 2004, 12, 1029); Jiang Fengchao et al. described 4-arylthiazole-2-imine derivatives with inhibitory activity on apoptosis (Journal of Pharmacy, 2006, 41: 727). Lin et al. described the selective inhibition of COX-2 by Schiff bases (Bioorg & Med Chem, 2008, 16(5):2697). He Daohang et al. described the synthesis and bactericidal activity of 4-aryl-...

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Application Information

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IPC IPC(8): C07D417/14A01N43/78A01P7/04
Inventor 陈平罗先福
Owner CHANGSHA UNIVERSITY OF SCIENCE AND TECHNOLOGY