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Composition comprising antibiotic and corticosteroid

A composition and antibiotic technology, which can be applied in the direction of drug combination, medical preparations containing active ingredients, antibacterial drugs, etc., and can solve the problems of increased degradation products of mometasone

Active Publication Date: 2013-10-23
INTERVET INT BV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Applicants have observed that at least one mometasone degradation product increases over time when the above formulation is stored at room temperature

Method used

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  • Composition comprising antibiotic and corticosteroid
  • Composition comprising antibiotic and corticosteroid
  • Composition comprising antibiotic and corticosteroid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0131] Example 1. Stabilization of suspensions using oleic or lauric acid

[0132] The purpose of this experiment was to demonstrate that oleic or lauric acid can reduce the formation of at least one mometasone degradation product in a suspension comprising a combination of mometasone furoate monohydrate and orbifloxacin. In this experiment, the suspension had the composition shown in Table 8:

[0133] Table 8

[0134] Suspension containing mometasone compound and fluoroquinolone antibiotic

[0135]

[0136] The suspension was divided into small portions. Oleic acid was added to each aliquot to achieve a specific oleic acid concentration (0.1%, 0.2%, 0.5%, 1.0% or 2.0%); lauric acid was added to achieve a specific lauric acid concentration (0.1%, 0.2%, 0.5% or 1.0%); or no addition of oleic acid or lauric acid (ie, control group). Aliquots were filled into 7.5 g HDPE plastic bottles with LDPE caps and then placed in an upright position on stable containers. To avoid an...

Embodiment 2

[0142] Example 2. Illustrative otic formulations comprising oleic acid

[0143] Table 10 below illustrates compositions of the present invention comprising oleic acid.

[0144] Table 10

[0145] Illustrative otic formulation comprising oleic acid

[0146]

Embodiment 3

[0147] Example 3. Illustrative otic formulations comprising lauric acid

[0148] Table 11 below illustrates compositions of the present invention comprising lauric acid.

[0149] Table 11

[0150] Illustrative otic formulation comprising oleic acid

[0151]

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Abstract

This invention relates to compositions (e.g., otic compositions) comprising an antibiotic (generally a quinolone or naphthyridinone), corticosteroid, and organic acid (generally a fatty acid). This invention also relates to treatment methods using such a composition, uses of such a composition to make medicaments, and therapeutic kits comprising such a composition.

Description

field of invention [0001] The present invention relates to compositions comprising an antibiotic, typically a quinolone or a naphthyridinone, a corticosteroid, and an organic acid, typically a fatty acid. The present invention also relates to a treatment method using the composition, an application of the composition to prepare medicine, and a treatment kit comprising the composition. Background of the invention [0002] US Patent Application Publication 2006-0122159 discusses pharmaceutical formulations for the treatment of infections, particularly ear infections, in animals. The composition is generally described as comprising a corticosteroid, an antibiotic and a triazole. These include, for example, suspensions comprising mometasone furoate monohydrate, orbifloxacin and posaconazole. A specific formulation described in US Patent Application Publication 2006-0122159 is shown in Table 1: [0003] Table 1 [0004] Formulation of Example 1 of US Patent Application Public...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/10A61K47/12A61K9/00A61K31/496A61K31/58
CPCA61K47/12A61K9/14A61K9/0046A61K31/496A61K31/58A61K9/10A61K45/06A61P27/16A61P31/00A61P31/04A61P31/10A61K2300/00
Inventor R·塔利K·弗里霍夫J·布拉姆菲尔德
Owner INTERVET INT BV
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