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Use of nifurtimox for treating giardiasis

A technology of nifurtimox and disease, applied in the direction of resistance to vector-borne diseases, medical preparations containing active ingredients, drug combinations, etc., can solve problems such as treatment failure

Inactive Publication Date: 2011-06-01
BAYER IP GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] Many of these types of active substances have been used to treat giardiasis for a long time, and for most resistance can be detected and proven to lead to treatment failure

Method used

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  • Use of nifurtimox for treating giardiasis
  • Use of nifurtimox for treating giardiasis
  • Use of nifurtimox for treating giardiasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0100] Embodiment 1 (liquid preparation):

[0101] Suspension with the following drugs in 100 ml of glycerol formaldehyde / glycerol macrogol ricinoleate (Cremophor® EL) / water with a mixing ratio of 1:10:

[0102] ● 500 mg nifurtimox

[0103] ● 1000 mg nifurtimox

Embodiment 2

[0104] Embodiment 2 (liquid preparation):

[0105] Suspension with the following drugs in 100 ml of Cremophor® EL / water with a mixing ratio of 1:5

[0106] ● 500 mg nifurtimox

[0107] ● 1000 mg nifurtimox

Embodiment 3

[0108] Embodiment 3 (solid preparation)

[0109] The active substance is filled in powder form into gelatin capsules in the following amounts:

[0110] ● 250 mg nifurtimox

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PUM

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Abstract

The present invention relates to the use of nifurtimox for the treatment of giardiasis, particularly in dogs and cats.

Description

technical field [0001] The present invention relates to the use of nifurtimox for the treatment of Giardiose, especially in dogs and cats. Background technique [0002] The efficacy of nitroheterocyclic compounds against protozoan diseases is known (1). [0003] Protozoa include monokaryotic organisms whose basic structure is eukaryotic cells. However, a more detailed taxonomy reveals large differences in origin, morphology, and biochemical metabolism among lines, classes, genera, and species. This is why, depending on their target and active ingredient, chemicals generally do not act equally well on all protozoa, but only on specific groups of protozoa (2, 3, 4). [0004] So far, nifurtimox has only been described to have efficacy against protozoan species of the genus Trypanosoma, such as Trypanosoma brucei and Trypanosoma cruzi (5). Trypanosomes have flagella that originate from a basal body ("tricola basal body"), to which they attach to produce a corrugated membrane....

Claims

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Application Information

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IPC IPC(8): A61K31/541A61K38/15A61P33/02
CPCA61K38/15A61K31/541A61K9/0095A61K9/4841A61K9/10A61P33/00A61P33/02A61P33/10Y02A50/30A61K2300/00
Inventor G.格雷夫A.哈德T.巴赫G.佩特里E-M.克鲁德瓦根
Owner BAYER IP GMBH
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