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Ophthalmic gel and preparation method thereof

A technology for ophthalmic gels and gels, which can be applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., and can solve problems such as potential safety hazards

Active Publication Date: 2011-06-08
SHENYANG XINGQI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the incidence of glaucoma in the elderly is high, and timolol has adverse reactions in the cardiovascular system and respiratory system, so the clinical application of latan timol eye drops has potential safety hazards, which limits its application

Method used

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  • Ophthalmic gel and preparation method thereof
  • Ophthalmic gel and preparation method thereof
  • Ophthalmic gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0112] Prepare the ophthalmic gel according to the following prescription ratio.

[0113] Latanoprost 0.05g

[0114] Timolol Maleate 3.42g

[0115] Polyoxyethylene 40 hydrogenated castor oil 1.0g

[0116] Benzalkonium Chloride 0.08g

[0117] Sodium dihydrogen phosphate monohydrate 4.05g

[0118] Disodium hydrogen phosphate 5.30g

[0119] Hydroxypropyl methylcellulose (60SH-50) 50g

[0120] Sodium chloride 4.8g

[0121] Add water for injection to 1000g

[0122] Preparation method: take the prescribed amount of hydroxypropyl methylcellulose, swell with an appropriate amount of water for injection, overnight, sterilize by autoclaving at 121°C for 30 minutes, pass through a 400-mesh sieve, and set aside; take the prescribed amount of latanoprost, add the prescribed amount of polymer Oxyethylene 40 hydrogenated castor oil, mix well, add about 500g of water for injection at 80-90°C, stir to dissolve, add benzalkonium chloride, timolol maleate, sodium dihydrogen phosphate mono...

Embodiment 2

[0124] Operate as in Example 1, replacing hydroxypropyl methylcellulose with sodium carboxymethylcellulose to prepare an ophthalmic gel.

Embodiment 3

[0126] Prepare the ophthalmic gel according to the following prescription ratio.

[0127] Latanoprost 0.05g

[0128] Timolol Maleate 3.42g

[0129] Polyoxyethylene 40 hydrogenated castor oil 1.0g

[0130] Benzalkonium Chloride 0.08g

[0131] Polyvinyl alcohol 5g

[0132] Carbomer 980P 40g

[0133] Glycerin 20g

[0134] Sodium hydroxide 1.75g

[0135] Add water for injection to 1000g

[0136] Preparation method: Take the prescribed amount of Carbomer 980P, swell with an appropriate amount of water for injection, overnight, sterilize by autoclaving at 121°C for 30 minutes, pass through a 400-mesh sieve, and set aside; take the prescribed amount of polyvinyl alcohol and heat it to 90 with an appropriate amount of water for injection. Dissolve at ℃, autoclave at 121℃ for 30 minutes, pass through a 400-mesh sieve, and set aside; take the prescribed amount of latanoprost, add the prescribed amount of polyoxyethylene 40 hydrogenated castor oil, mix well, add water for injectio...

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PUM

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Abstract

The invention relates to an ophthalmic gel and a preparation method thereof, in particular to the ophthalmic gel. The ophthalmic gel comprises effective quantity of latanoprost and timolol or salts thereof for treatment and / or prevention, a gel matrix, a surfactant and water. The invention also comprises the ophthalmic gel, an ophthalmic preparation of a medicinal excipient mixed with the ophthalmic gel before being used, and the preparation method of the ophthalmic gel. The ophthalmic gel has the favorable effects of treating eye diseases, and has less adverse effects on a cardiovascular system and a respiratory system of the whole body.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to an ophthalmic gel for treating glaucoma, in particular to an ophthalmic gel containing active ingredients latanoprost and timolol or salts thereof. Background technique [0002] Glaucoma is generally defined as a group of clinical syndromes or eye diseases that threaten and impair optic nerve visual function, mainly related to pathological elevated intraocular pressure. Increased intraocular pressure is an important factor in the progression of glaucomatous optic nerve damage. If the intraocular pressure exceeds the limit that the tissues in the eyeball, especially the optic nerve of the retina, can bear, it will cause damage to the tissues in the eyeball (including the cornea, iris and lens), especially the visual function of the optic nerve. The most typical and prominent manifestation Depressed atrophy of the optic nerve head and narrowing of the characteristic defect...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/5575A61K47/32A61K47/34A61K47/36A61K47/38A61P27/06A61K31/5377A61K47/10
Inventor 刘继东唐海杨宇春于叶玲
Owner SHENYANG XINGQI PHARM CO LTD
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