Preparation method of technetium labeled pyrroloquinoline quinone dimethyl ester

A technology of quinoline quinone dimethyl ester and dimethyl ester, which is applied in the field of biotechnology and medicine, and can solve the problems of affecting the amount of brain intake and large water solubility

Inactive Publication Date: 2011-06-15
JIANGSU INST OF NUCLEAR MEDICINE
View PDF1 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A document [YanyanKong, JRadioanalNuclChem, 2010] reported that PQQ was used as a ligand to complex with 99mTc to study the changes of N-methyl-D-aspartic acid (NMDA) receptors, but its water solubility is relatively large, which affects its entry into the brain. quantity

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of technetium labeled pyrroloquinoline quinone dimethyl ester
  • Preparation method of technetium labeled pyrroloquinoline quinone dimethyl ester
  • Preparation method of technetium labeled pyrroloquinoline quinone dimethyl ester

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 199

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides a preparation method of technetium labeled pyrroloquinoline quinone dimethyl ester, belonging to the fields of biotechnology and medicine. By the preparation method, the structure of pyrroloquinoline quinone (PQQ) is modified, and PQQ-Z is prepared; and 99mTc labeling is carried out, and 99mTc-PQQ-Z is prepared. The product 99mTc-PQQ-Z has high radiochemical purity; and compared with the 99mTc-PQQ, the lipid / water partition coefficient of the 99mTc-PQQ-Z is increased from 1.49 to 0.67, the electrical property of the 99mTc-PQQ-Z is changed from anion electrical property to electric neutrality, and the brain entering amount of the 99mTc-PQQ-Z is twice of that of the 99mTc-PQQ.

Description

A kind of preparation method of technetium-labeled pyrroloquinoline quinone dimethyl ester technical field The invention discloses a preparation method of technetium-labeled pyrroloquinoline quinone dimethyl ester, which belongs to the fields of biotechnology and medicine. Background technique Pyrroloquinolinequinone (PQQ) is a new oxidoreductase prosthetic group discovered in the late 1970s. Its molecule has a planar conjugated molecular structure, conjugated diquinone (orthoquinone) and polyanions (three carboxyl groups). Pyrroloquinone quinone has a protective effect on neuroactivity, has an inhibitory effect on amyloid plaques, and also has a modulatory effect on N-methyl-D-aspartate receptor (NMDAR)-mediated excitotoxicity, and As a potential drug for the treatment of geriatric diseases, it has aroused the interest of neuroscience workers. A document [YanyanKong, JRadioanalNuclChem, 2010] reported that PQQ was used as a ligand to complex with 99mTc to study the chan...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): C07D471/04
Inventor 周杏琴孔艳艳张建康曹国宪
Owner JIANGSU INST OF NUCLEAR MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap