Clonidine hydrochloride sustained release micropill preparation

A technology of clonidine hydrochloride and sustained-release pellets, which can be used in cardiovascular system diseases, block delivery, drug combination, etc. The incidence of reaction, the effect of high and stable blood concentration

Active Publication Date: 2012-09-05
HEFEI COSOURCE PHARMA CO LTD
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Patients with high blood pressure need long-term medication, taking too many times a day will cause great obstacles to medication compliance, and there may be missed doses, which will affect the curative effect

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Clonidine hydrochloride sustained release micropill preparation
  • Clonidine hydrochloride sustained release micropill preparation
  • Clonidine hydrochloride sustained release micropill preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] (1) Preparation of pill-containing core (A)

[0047] Clonidine hydrochloride

4.0g

Blank pellet core (sucrose type)

1600g

Opadry (CLEAN)

40.0g

purified water

760.0g

[0048] Preparation Process:

[0049] Weigh Opadry (CLEAN), add it to purified water and stir to dissolve, pass a 100-mesh sieve just before use, then add the prescription amount of clonidine hydrochloride raw material, stir and dissolve, to obtain a coating liquid. Weigh the blank pellets and add them to the fluidized bed coating machine (WBF-5G, Chongqing Yingge Granulation Coating Technology Co., Ltd.), and use the low spray coating system (Wurster system) for coating. The coating parameters of the equipment are :Inlet air volume 250m 3 / hr, inlet air temperature 50℃, atomization pressure 2kg / cm 2 , The flow rate of the coating liquid is 7rpm. After the coating liquid is sprayed, it is fluidized and dried for 10 minutes and then discharged to obtain a pill-containing core.

[0050] (2) Isol...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
diameteraaaaaaaaaa
separationaaaaaaaaaa
Login to view more

Abstract

The invention relates to the field of medicinal preparations, in particular to a clonidine hydrochloride sustained release preparation and a preparation method thereof. The clonidine hydrochloride sustained release preparation is characterized in that: a sustained release coating membrane is divided into two layers, wherein a sustained release coating membrane of an inner layer contains a pore-forming agent, and a sustained release coating membrane on an outer layer does not contain the pore-forming agent; and a weight ratio of a sustained release coating on the inner layer to a sustained release coating of the outer layer is (1:1)-(2:5), and the weight of sustained release coatings on inner and outer layers are increased by 7 to 8 percent. In the sustained release preparation, two sustained release layers are coated, so that medicaments are released slowly, safely and effectively.

Description

Technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a sustained-release preparation of clonidine hydrochloride and a preparation method thereof. Background technique [0002] Clonidine hydrochloride has a chemical name: 2-[(2,6-dichlorophenyl)imino]imidazolidine hydrochloride. It is an antihypertensive drug that is well absorbed in the gastrointestinal tract. After oral administration, 70% to 80% is absorbed and quickly distributed to various organs. The concentration of the drug in the tissue is higher than that in the plasma, and it can accumulate in the blood-brain barrier. brain tissue. The protein binding rate is 20%-40%. Half an hour to 1 hour after oral administration, the blood pressure will be lowered, and the blood concentration will reach the peak at 3 to 5 hours, usually 1.35 ng / ml, and the effect will last for 6 to 8 hours. The elimination half-life is 12.7 (6-23) hours, and it is prolonged with renal insuffic...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K31/4168A61K47/38A61P9/12
Inventor 高署
Owner HEFEI COSOURCE PHARMA CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap