Method for producing a target substance using a simulated moving bed chromatography separation system

A technology for simulating a moving bed and a target substance, which is applied in the field of manufacturing target substances, and can solve the problems of increasing the circulating flow of the incapable eluent and increasing the pressure loss, and achieve the effect of suppressing the decline of the separation performance.

Active Publication Date: 2011-08-03
DAICEL CHEM IND LTD
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  • Abstract
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Problems solved by technology

As a countermeasure against such a tendency, a column with a large ratio of length to diameter is used in order to extend the switching interval of pump control.

Method used

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  • Method for producing a target substance using a simulated moving bed chromatography separation system
  • Method for producing a target substance using a simulated moving bed chromatography separation system
  • Method for producing a target substance using a simulated moving bed chromatography separation system

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Embodiment Construction

[0050] The present invention is a method for isolating a production target substance from a sample, that is, in the method for separating a production target substance from a sample using an SMBC separation device, the first SMBC separation device that satisfies the first condition can be used to separate the production target substance in the sample. The sample of the target substance is used in a second SMBC separation device satisfying the second condition to separate and manufacture the target substance from the sample.

[0051] As the above-mentioned SMBC separation device satisfying the first and second conditions, a known SMBC separation device can be used. Such an SMBC separation device includes a device as described in Japanese Patent Application Laid-Open No. 2006-84457, which includes: an annular flow path connected to an arbitrary connection flow path, and a first section for supplying an eluent to the annular flow path. One flow path is connected to any connection...

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Abstract

Disclosed is a method for separating and producing a target substance from a mixture using a simulated moving bed chromatography (SMBC) separation system, which can minimize decreases in separation performance due to interference from residual solution components. A specimen, in which a target substance in the specimen can be separated using a first SMBC system that meets first parameters, is processed to separate and produce the target substance from the specimen using a second SMBC separation system that meets second parameters, wherein the grain size of a separating agent and the fill length of a column tube are both greater, the pressure loss by the column is substantially the same, and the volume ratio of residual solution components in the endless flow path of the SMBC separation system is lower.

Description

technical field [0001] The present invention relates to a method for producing a target substance using a simulated moving bed chromatography separation device (hereinafter also referred to as "SMBC separation device"). Background technique [0002] As a method for separating and obtaining arbitrary components in a mixture, there is known a simulated moving bed method (hereinafter also referred to as "SMB method") in which, using an SMBC separation device, continuous The eluent and the sample solution are supplied while the eluent is continuously discharged from the loop flow path. Optical resolution using the SMB method is attracting attention especially in the field of medicine. When the SMB method is used to manufacture products that require extremely high purity, such as pharmaceuticals, the purity of the separated components is often reduced due to slight disturbances, and the yield may be greatly reduced. [0003] For example, in general, in optical resolution using ...

Claims

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Application Information

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IPC IPC(8): B01D15/00G01N30/46G01N30/60G01N30/88
CPCB01D15/1842B01D15/1828B01D15/00G01N30/46G01N30/60G01N30/88
Inventor 蓑田稔治
Owner DAICEL CHEM IND LTD
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