Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for producing a target substance using a simulated moving bed chromatography separation system

A technology for simulating a moving bed and a target substance, which is applied in the field of manufacturing target substances, and can solve the problems of increasing the circulating flow of the incapable eluent and increasing the pressure loss, and achieve the effect of suppressing the decline of the separation performance.

Active Publication Date: 2011-08-03
DAICEL CHEM IND LTD
View PDF9 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a countermeasure against such a tendency, a column with a large ratio of length to diameter is used in order to extend the switching interval of pump control. However, since the pressure loss generated by the column becomes large at this time, the The circulation flow rate of the eluent cannot be increased sufficiently

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for producing a target substance using a simulated moving bed chromatography separation system
  • Method for producing a target substance using a simulated moving bed chromatography separation system
  • Method for producing a target substance using a simulated moving bed chromatography separation system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0050] The present invention is a method for isolating a production target substance from a sample, that is, in the method for separating a production target substance from a sample using an SMBC separation device, the first SMBC separation device that satisfies the first condition can be used to separate the production target substance in the sample. The sample of the target substance is used in a second SMBC separation device satisfying the second condition to separate and manufacture the target substance from the sample.

[0051] As the above-mentioned SMBC separation device satisfying the first and second conditions, a known SMBC separation device can be used. Such an SMBC separation device includes a device as described in Japanese Patent Application Laid-Open No. 2006-84457, which includes: an annular flow path connected to an arbitrary connection flow path, and a first section for supplying an eluent to the annular flow path. One flow path is connected to any connection...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Disclosed is a method for separating and producing a target substance from a mixture using a simulated moving bed chromatography (SMBC) separation system, which can minimize decreases in separation performance due to interference from residual solution components. A specimen, in which a target substance in the specimen can be separated using a first SMBC system that meets first parameters, is processed to separate and produce the target substance from the specimen using a second SMBC separation system that meets second parameters, wherein the grain size of a separating agent and the fill length of a column tube are both greater, the pressure loss by the column is substantially the same, and the volume ratio of residual solution components in the endless flow path of the SMBC separation system is lower.

Description

technical field [0001] The present invention relates to a method for producing a target substance using a simulated moving bed chromatography separation device (hereinafter also referred to as "SMBC separation device"). Background technique [0002] As a method for separating and obtaining arbitrary components in a mixture, there is known a simulated moving bed method (hereinafter also referred to as "SMB method") in which, using an SMBC separation device, continuous The eluent and the sample solution are supplied while the eluent is continuously discharged from the loop flow path. Optical resolution using the SMB method is attracting attention especially in the field of medicine. When the SMB method is used to manufacture products that require extremely high purity, such as pharmaceuticals, the purity of the separated components is often reduced due to slight disturbances, and the yield may be greatly reduced. [0003] For example, in general, in optical resolution using ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): B01D15/00G01N30/46G01N30/60G01N30/88
CPCB01D15/1842B01D15/1828B01D15/00G01N30/46G01N30/60G01N30/88
Inventor 蓑田稔治
Owner DAICEL CHEM IND LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com