Preparation method of liposome with functions of fat reduction and calcium supplement

A lipid and calcium supplement technology, applied in the directions of liposome delivery, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve the problem that the transformation of lecithin into liposomes cannot be effectively controlled, and the effect of functional ingredients cannot be maximized. , It is not suitable for people with stomach diseases to take it, so as to maintain the characteristics of no side effects, prevent and treat arteriosclerosis, and prevent Alzheimer's disease.

Inactive Publication Date: 2011-10-05
ANHUI FINDSHE BIOLOGICAL PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] 1. The taste is not good, especially the fishy smell released by the ineffective ingredient egg white is unacceptable to many people;
[0018] 2. The product has a single form, lacks disinfection and sterilization measures, cannot be stored for a long time, and is easily corrupted and deteriorated to affect the effect;
[0019] 3. It is impossible to effectively control the conversion of lecithin into liposomes, and the conversion rate is low;
[0020] 4. The encapsulation efficiency of liposomes to calcium acetate and ionic calcium hydroxide is lower, and the effect of functional components cannot be maximized;
[0021] 5. Excessive acidity can easily irritate the stomach and intestines, so it is not suitable for people with stomach problems

Method used

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  • Preparation method of liposome with functions of fat reduction and calcium supplement
  • Preparation method of liposome with functions of fat reduction and calcium supplement
  • Preparation method of liposome with functions of fat reduction and calcium supplement

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Embodiment Construction

[0044] The liposome of present embodiment has the function of reducing fat and replenishing calcium is to carry out as follows:

[0045] 1. Add acetone to the concentrated soybean phospholipid or egg yolk to deoil, heat to 45°C and stir well, then centrifuge with a centrifuge, take the insoluble precipitate, add absolute ethanol to dissolve and extract, purify at 55°C for 90 minutes, and then remove For ethanol insoluble matter, add aluminum oxide to the ethanol soluble matter for adsorption and decolorization, then filter, distill the filtrate under reduced pressure, distill off ethanol, and dry it in vacuum to obtain purified lecithin. Water and ethanol are used to obtain oily phase substances.

[0046] 2. Soak eggshells or raw materials rich in calcium carbonate in vinegar with a concentration of not less than 9g / 100ml, the mass ratio of raw materials to vinegar is 1:20; or according to the mass of calcium hydroxide, anhydrous acetic acid and water The ratio is 1: 2: 16, f...

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Abstract

The invention discloses a preparation method of a liposome with functions of fat reduction and calcium supplement. The preparation method is characterized in that: on the basis of defining the therapeutic and health-care mechanism of a folk recipe, namely vinegar egg liquid, an ethanol injection method, an original sleeve dual-ejection technology and a homogenizing device with smeared sealing function are combined to reinforce the formation of the liposome of lecithin and the package of calcium acetate; the calcium acetate packaged by the liposome is transformed into ionic calcium hydroxide by transferring the liposome with the acetic acid through a calcium acetate gradient method; the liposome rich in the ionic calcium hydroxide is processed into an oral solution or freeze-dried powder. Compared with the traditional folk recipe, namely the vinegar egg liquid, the biological product developed by the method contributes more to massive production and long-term preservation and is more easy to absorb by a human body; the utilization of the calcium ions by the human body is greatly improved; the acidity of the human body is reduced; a healthy alkalescent environment is created in the human body; the fat-reducing function of the human body is enhanced; the target characteristic of softening blood vessels is more outstanding; and the therapeutic and health-care effect is more obvious.

Description

technical field [0001] The invention relates to a liposome preparation process. Specifically, a preparation process of lipid-lowering and calcium-supplementing biological products with targeted functions. Background technique [0002] According to statistics, currently about 30-40% of the people suffer from abnormal blood lipid metabolism beyond borderline standards, that is, hyperlipidemia. Hyperlipidemia is the main factor causing human atherosclerotic diseases, which can easily lead to hypertension, diabetes, coronary heart disease, cerebral infarction and peripheral vascular embolism. Hyperlipidemia can also lead to obesity, causing a large amount of lipid proteins to dissociate in the blood plasma, causing oxidative rancidity and acidification of the body. The human body needs a relatively stable weakly alkaline internal environment. When the human body is weakly alkaline, it can independently decompose excess lipids in the blood tissue to prevent the occurrence of a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/19A61K31/685A61K9/127A61P3/02A61K9/19A61P3/06A61K9/00A61J3/00A61J3/02
Inventor 尚诚德
Owner ANHUI FINDSHE BIOLOGICAL PHARMA CO LTD
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