Column chromatography separating unit

Abstract

The invention discloses a column chromatography separation device, which includes a spherical condensation tube, a serpentine condensation tube, a chromatography column, a reaction vessel and a heating device, in which the outer grinding port of the lower part of the spherical condensation tube is connected to the inner grinding port of the serpentine condensation tube. The outer grinding port of the serpentine condenser tube is connected to the inner grinding port of the chromatography column, and the outer grinding port of the chromatography column is connected to the reaction vessel; a connected side pipe is provided between the upper end of the chromatography column body and the upper edge of the outer grinding port of the chromatography column. The invention integrates mixture separation and concentration. Since each connection is connected with a ground connection, the mixture can be separated and concentrated in a relatively closed pipeline, reducing the contact between easily oxidized and easily decomposed substances and air, and reducing solvent loss. while preventing environmental pollution.

Description

technical field [0001] The invention relates to a column chromatography separation device, in particular to an integrated, recyclable and environment-friendly column chromatography separation device, which can be applied to the fields of chemical engineering, pharmaceutical engineering, food engineering and the like. Background technique [0002] Chromatography technology is a technology that separates and purifies substances according to the different physical, chemical or biological properties of different substances in different media and different migration speeds. It has been widely used in chemical, food, pharmaceutical and other industries. Column chromatography is one of the most commonly used separation means in the chromatography process. Commonly used column chromatography methods can be divided into normal pressure method, negative pressure method and pressurized method according to different separation pressures. Atmospheric pressure column chromatography is th...

AI Technical Summary

Problems solved by technology

However, the device needs manual addition of eluent, lacks anti-volatility protection for eluent and eluent, and cannot be operated continuously

[0006] To sum up, the current common column chromatography devices have the following deficiencies: usually separation and concentration recovery are carried out step by step, the solvent needs to be frequently replenished into the chromatography column, and the receiving bottle also needs to frequently recover the solvent by means of rotary evaporation, etc. On the one hand, it is easy to cause dry column, and on the other hand, for substances that are unstable, easy to decompose, and easy to oxidize, they will be decomposed or oxidized due to prolonged exposure to air or high ambient temperature.

In addition, commonly used separation solvents are toxic to a certain extent, and they volatilize in the air for a long time. On the one hand, they will cause volatilization loss, and on the other hand, they will pose a threat to the health of the operator.

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