Novel blood lipid lowering composition
A composition and a blood lipid-lowering technology, applied in the field of medicine, can solve problems such as unsatisfactory treatment effect and the like
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Embodiment 1
[0014] Embodiment 1: tablet
[0015] Name of raw material
1
2
3
4
5
Alikren Fumarate
150g
150g
150g
150g
150g
5g
----
----
----
----
----
100g
----
----
100g
----
----
250g
375g
500g
----
----
----
10g
----
85g
80g
45g
65g
75g
36g
36g
36g
36g
36g
Sodium carboxymethyl cellulose
10g
10g
10g
10g
10g
5% PVP K30 solution
Appropriate amount
Appropriate amount
Appropriate amount
Appropriate amount
Appropriate amount
1.6g
1.6g
1.6g
1.6g
1.6g
[0016] Note: Aliklen fumarate specifications ar...
Embodiment 2
[0018] Embodiment 2: Sustained-release tablet
[0019] Name of raw material
1
2
3
Alikren Fumarate
150g
150g
150g
----
----
----
----
----
100g
250g
375g
500g
----
10g
----
Hypromellose E10M
101.5g
185g
203g
PVP K90
8.75g
105g
17.5g
Sodium carboxymethyl cellulose
10g
10g
10g
56g
56g
56g
45g
45g
45g
1.6g
1.6g
1.6g
Appropriate amount
Appropriate amount
Appropriate amount
[0020] Note: Aliklen fumarate specification is calculated by Aliklen, levamlodipine besylate is calculated by amlodipine
[0021] Process: take each raw material, crush and pass thr...
Embodiment 3
[0022] Embodiment 3: lipid-lowering effect experiment
[0023] Male Wistar rats (grade 2), weighing 160-170 g. Give high-fat diet 25g (high-fat feed formula: basal feed: cholesterol: lard: cholate: methylthiouracil = 8418: 4: 10: 1: 012) in a quantitative manner every day for 26 days, and the establishment of hyperlipidemia mouse model.
[0024] In addition to a blank control group (0) that was not given high-fat feed, the experimental animals that successfully established the model were randomly divided into model group (A), simvastatin (B1), aliskiren + simvastatin (B2), fenofibrate (C1), aliskiren + fenofibrate (C2), niacin (D1), aliskiren + niacin (D2), aliskiren + niacin + simvastatin (E), Aliskiren + fenofibrate + simvastatin (F), Aliskiren + niacin + fenofibrate group (G), etc. All the drugs were suspended in 0.5% sodium carboxymethylcellulose and administered by intragastric administration once a day for 10 consecutive days. After 10 days, blood was collected from ...
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Abstract
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