Preparation method of albendazole

A technology of albendazole and compounds, which is applied in the field of preparation of new albendazole, can solve the problems of low total yield and great harm to human body, and achieve the effects of simple operation, small damage and cost reduction
CN102250013AActive Publication Date: 2011-11-23湖南欧亚药业有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
湖南欧亚药业有限公司
Publication Date
2011-11-23

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Abstract

The invention discloses a preparation method of albendazole. In the method, a compound as shown in a formula (I) is used as a raw material, and albendazole is obtained through two steps of bromination and substitution. The preparation method has the advantages of less steps, cheap and available raw material, little pollution and high yield, is simple to operate and is suitable for industrial production.
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Description

technical field

[0001] The present invention relates to a kind of preparation method of novel albendazole. Background technique

[0002] Albendazole (Albenzadole), also known as albendazole, chemically named 5-propylthio-1H-benzimidazole-2-carbamate methyl ester, is a spectrally efficient and low-toxic anthelmintic drug. The drug is produced by the United States. Smith Kline was first listed in the market in 1977, and it is widely used clinically in various helminth infectious diseases. Its mechanism of action is mainly to inhibit the fumarate reductase of the worm body, prevent the energy generation of the worm body, and thus achieve the purpose of killing the worm body. The drug has a strong killing effect on human and animal parasitic nematodes, trematodes and tapeworms, and can significantly inhibit the development of eggs, and has no accumulation in the body. Other helminth drugs, the drug has now been included in the medical insurance products, and has become the firs...

Claims

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