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Amorphous state ginsenoside Rg1 and preparation method thereof

A ginsenoside, amorphous form technology, applied in the field of ginsenoside Rg1 and its preparation, can solve the problems of poor solubility, reduced solubility and bioavailability of ginsenoside Rg1, etc., and achieves the effect of good solubility

Active Publication Date: 2013-03-20
KPC PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] When the present inventor tested the ginsenoside Rg1 prepared in the above-mentioned prior art using the X-ray diffraction method, he found that it had the following properties: figure 2 The X-ray diffraction pattern shown is an amorphous form. Studies have shown that the solubility of ginsenoside Rg1 in this amorphous form is poor, and the poor solubility will reduce the bioavailability of ginsenoside Rg1

Method used

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  • Amorphous state ginsenoside Rg1 and preparation method thereof
  • Amorphous state ginsenoside Rg1 and preparation method thereof
  • Amorphous state ginsenoside Rg1 and preparation method thereof

Examples

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Effect test

Embodiment 1

[0036] Take 5g of ginsenoside Rg1 and dissolve it in 25ml of methanol with a water content of 2wt%, stir for 10 minutes to completely dissolve ginsenoside Rg1, heat methanol to 50°C during the dissolution process, and then recover under reduced pressure at 50°C methanol to dryness to obtain sample 1;

Embodiment 2

[0038] Take 5g of ginsenoside Rg1 and dissolve it in 26ml of methanol with a water content of 5wt%, stir for 10 minutes to completely dissolve ginsenoside Rg1, heat methanol to 50°C during the dissolution process, and then recover under reduced pressure at 50°C methanol to dryness to obtain sample 2.

Embodiment 3

[0040] Take 5g of ginsenoside Rg1 and dissolve it in 20ml of ethanol with a water content of 2wt%, stir for 10 minutes to completely dissolve ginsenoside Rg1, heat methanol to 50°C during the dissolution process, and then recover under reduced pressure at 50°C methanol to dryness to obtain sample 3.

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Abstract

The invention provides amorphous state ginsenoside Rg1 which has an X-ray diffraction spectrum basically as shown in a figure 1 described in the specification. The invention also provides a preparation method of the amorphous state ginsenoside Rg1, comprising the following steps of: dissolving ginsenoside Rg1 into hydrous lower chain alkanol, wherein the lower chain alkanol contains 1-4 carbon atoms, and the water content of the lower chain alkanol is 2-5 percent by weight; and carrying out reduced-pressure recovery on the lower chain alkanol dissolved with ginsenoside so as to obtain the amorphous state ginsenoside Rg1. compared with the prior art, the amorphous state ginsenoside Rg1 provided by the invention has better solubility.

Description

technical field [0001] The invention relates to a ginseng extract, in particular to a ginsenoside Rg1 and a preparation method thereof. Background technique [0002] Ginsenoside Rg1 is the main active ingredient extracted from Panax notoginseng. Studies have shown that ginsenoside Rg1 has good pharmacological activity: for example, ginsenoside Rg1 can improve ischemia-reperfusion in rats by inhibiting leukocyte infiltration and adhesion molecule expression. Injury; Ginsenoside Rg1 has a significant protective effect on apoptosis caused by cerebral ischemia-reperfusion injury in rats; moreover, ginsenoside Rg1 has a protective effect on ischemic myocardium. Therefore, ginsenoside Rg1 has the prospect of being developed as a drug for treating cardiovascular and cerebrovascular diseases. In addition, further research experiments have shown that ginsenoside Rg1 also has pharmacological effects such as immune promotion, anti-aging, and intelligence. [0003] In the prior art, a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J17/00
Inventor 龚云麒高宏涛刘一丹杨旭娟
Owner KPC PHARM INC
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