Traditional Chinese medicine preparation for treating chronic and nonspecific ulcerative colitis and preparation method thereof

A non-specific technology for ulcerative colitis, applied in the direction of pharmaceutical formulations, drug combinations, medical preparations containing active ingredients, etc., can solve problems such as easy recurrence, unsatisfactory patient curative effect, and increased adverse reactions

Active Publication Date: 2011-11-30
重庆赛诺生物药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, western medicine treats ulcerative colitis with aminosalicylic acid and glucocorticoid chemical drugs. It is very easy to relapse after stopping the drug, and the adverse reactions of long-term medication increase, and the curative effect of patients with chronic recurrent acute exacerbation is not ideal

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0514] A modern Chinese medicine preparation for treating chronic nonspecific ulcerative colitis contains Auranthus chinensis, Polygonum syringae, Desmodium, Poria cocos, Atractylodes macrocephala, and patchouli; each raw material in the Chinese medicine preparation for treating chronic nonspecific ulcerative colitis The weight ratio is:

[0515] Cow ear maple 300~6000

[0516] Polygonum 200~4000

[0517] Money grass 200~2000

[0518] Poria cocos 50~1000

[0519] Atractylodes 50~1000

[0520] Patchouli 200~3000

[0521] The traditional Chinese medicine preparation for treating chronic non-specific ulcerative colitis is yellow-brown to brown-yellow powder or granule or liquid; the taste is slightly sweet and slightly bitter.

[0522] The dosage form of the traditional Chinese medicine preparation for treating chronic non-specific ulcerative colitis is a dropping pill, sealed and stored, and the usage is: oral administration.

[0523] The dosage form of the traditional Chi...

Embodiment 2

[0626] This example is another preferred solution based on Example 1, which is the preparation method adopted when the dosage form of the modern Chinese medicine preparation for treating chronic nonspecific ulcerative colitis is a tablet.

[0627] Ⅰ. Preparation of inclusion complexes

[0628] A. Treatment of Patchouli:

[0629] Wash the patchouli (stems and leaves) with purified water, dry and pulverize to obtain the pretreated patchouli;

[0630] Described patchouli is fresh dry product state;

[0631] The drying temperature is 40-42°C, preferably 41°C;

[0632] The pulverization is initial powder;

[0633] B. Extract volatile oil:

[0634] a. adding purified water to the patchouli pretreatment product to soak;

[0635] In the soaking treatment, the weight ratio of patchouli pretreated product to purified water is 1:6-8, preferably 1:7;

[0636] The soaking time is 1 to 3 hours, preferably 2 hours;

[0637] Described immersion temperature is normal temperature;

[06...

Embodiment 3

[0709] This example is another preferred solution based on Example 1, which is the preparation method adopted when the dosage form of the traditional Chinese medicine preparation for treating chronic non-specific ulcerative colitis is a capsule.

[0710] Ⅰ. Preparation of inclusion complexes

[0711] A. Patchouli Treatment:

[0712] Wash the patchouli (stems and leaves) with purified water, dry and pulverize to obtain the pretreated patchouli;

[0713] Described patchouli is fresh dry product state;

[0714] The drying temperature is 40-42°C, preferably 41°C;

[0715] The pulverization is initial powder;

[0716] B. Extract volatile oil:

[0717] a. adding purified water to the patchouli pretreatment product to soak;

[0718] In the soaking treatment, the weight ratio of patchouli pretreated product to purified water is 1:6-8, preferably 1:7;

[0719] The soaking time is 1 to 3 hours, preferably 2 hours;

[0720] Described immersion temperature is normal temperature;

...

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PUM

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Abstract

The invention relates to the field of the modern Chinese medicine preparation, in particular to a traditional Chinese medicine preparation for treating the chronic and nonspecific ulcerative colitis and a preparation method thereof. The traditional Chinese medicine preparation for treating the chronic and nonspecific ulcerative colitis contains daphniphyllum calycinum, red-knees herb, desmodium, poria cocos, rhizoma atractylodis macrocephalae and pogostemon cablin. In the invention, advanced water consumption process and the micromembrane separating technology are adopted, the relative molecular mass of the effective pharmacological ingredients is lower, the activity is high and diversified, the inflammation and the edema of the mucosal multiple ulcerative colitis can be directly restrained, the mucosal and vascular purulent secretion is eliminated, the inducing factors are improved and the immunity is enhanced. The traditional Chinese medicine preparation has the effects of clearing heat and toxin, promoting blood circulation and removing blood stasis, replenishing qi and invigorating the spleen, eliminating dampness and stopping diarrhea, is used for abdominal pain, diarrhea, bloody purulent stool, tenesmus and the like caused by qi stagnation and blood stasis, weakness of the spleen and the stomach, and internal dampness and heat, and is also used for the chronic and nonspecific ulcerative colitis or chronic recurrent acute exacerbation and acute gastroenteritis. The traditional Chinese medicine preparation has exact curative effect and high efficiency, and is safe and quick-acting.

Description

technical field [0001] The invention relates to the field of modern traditional Chinese medicine preparations, in particular to a traditional Chinese medicine preparation for treating chronic nonspecific ulcerative colitis and a preparation method thereof. technical background [0002] Chronic nonspecific ulcerative colitis (ulcerativecolitis, UC) was officially named by the World Health Organization (WHO) in 1973. In the past, my country believed that the disease was more common in European and American countries, but rare in Asian and African countries, so it did not pay enough attention to it. Medical research shows that chronic nonspecific ulcerative colitis is also a relatively common digestive tract disease in my country, and it is most common in young adults. According to statistics released by "World Chinese Journal of Digestion", the number of reported cases of the disease in my country has soared from more than 1,600 in 1999 to more than 50,000 in 2010. [0003] ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/704A61P1/04
Inventor 刘悉承骆俊红杨宪
Owner 重庆赛诺生物药业股份有限公司
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