Preparation method of Huoxiangzhengqi Oral Liquid

The technology of Zhengqi oral liquid and Huoxiang is applied in the field of preparation of traditional Chinese medicine preparations and can solve the problems of complicated process, long extraction time and high extraction temperature.

Active Publication Date: 2011-11-30
TAIJI GRP CHONGQING FULING PHARM FACTORY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the above methods, the reflux method is used to extract Magnolia officinalis, the decocting method is used to extract raw pinellia, and the 80°C soaking method is used to extract Poria cocos. There are cumbersome processes, long extraction time, high extraction temperature, high energy consumption, easy loss of heat-sensitive components, and dissolution of impurities. More, low recovery rate of active ingredients, troublesome post-processing, etc.
In addition, in the above method, the raw pinellia is soaked in water until it penetrates the heart, and then the dried ginger is added to the water and decocted. The disadvantages are: (1) Even if the dried pinellia is divided into different sizes and soaked until the heart is penetrated, it is difficult to achieve Very few pinellia tubers that are particularly large are soaked to the core. When the small pinellia tubers have already soaked, the extra large pinellia tubers are far from being penetrated. Repeated water changes and soaking will not only cause a large loss of active ingredients, but also easily cause small tubers to soak and rot The phenomenon of smelly and sour, the whole soaking process can last for several days; (2) Because Pinellia is rich in starch, when the cooking temperature is close to 100℃, the outer starch of Pinellia has already gelatinized, which will seriously hinder Dissolution of active ingredients in Pinellia tissue cells

Method used

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  • Preparation method of Huoxiangzhengqi Oral Liquid
  • Preparation method of Huoxiangzhengqi Oral Liquid

Examples

Experimental program
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Effect test

Embodiment 1

[0060] Prescription: Atractylodes 8kg, Chenpi 8kg, Magnolia officinalis (made from ginger) 8kg, Angelica dahurica 12kg, Poria cocos 12kg, Dabupi 12kg, raw pinellia 8kg, licorice extract 1kg, patchouli oil 80ml, perilla leaf oil 40ml

[0061] The preparation method comprises the following steps:

[0062] a. Magnolia officinalis extraction

[0063] a1. Crush Magnolia officinalis into coarse powder, set aside;

[0064] a2. Add 42% ethanol equivalent to 6 times of magnolia bark weight in batching tank; Switch the three-way valve to the batching tank position, open the agitator, diaphragm pump and diaphragm filter press of batching tank, and 42% ethanol in the batching tank Pump into the membrane filter press (using 5-8 L / m 2 .s polypropylene multifilament filter cloth), until the press filtrate returns to the batching tank, add the magnolia bark powder obtained in step a1 to the batching tank at a constant speed, after adding, the membrane filter press cycle extracts for 20 m...

Embodiment 2

[0089] Prescription: Atractylodes 8kg, Chenpi 8kg, Magnolia officinalis (made from ginger) 8kg, Angelica dahurica 12kg, Poria cocos 12kg, Dabupi 12kg, raw pinellia 8kg, licorice extract 1kg, patchouli oil 80ml, perilla leaf oil 40ml

[0090] The preparation method comprises the following steps:

[0091] a. Magnolia officinalis extraction

[0092] a1. Crush Magnolia officinalis into coarse powder, set aside;

[0093] a2. Add 35% ethanol equivalent to 3 times of Magnolia officinalis weight in batching tank; Switch the three-way valve to the batching tank position, open the agitator, diaphragm pump and diaphragm filter press of batching tank, and 35% ethanol in the batching tank Pump into the membrane filter press (using 5-8 L / m 2 .s polypropylene multifilament filter cloth), until the press filtrate returns to the batching tank, add the magnolia bark powder obtained in step a1 to the batching tank at a constant speed, after adding, the membrane filter press cycle extracts f...

Embodiment 3

[0118] Prescription: Atractylodes 8kg, Chenpi 8kg, Magnolia officinalis (made from ginger) 8kg, Angelica dahurica 12kg, Poria cocos 12kg, Dabupi 12kg, raw pinellia 8kg, licorice extract 1kg, patchouli oil 80ml, perilla leaf oil 40ml

[0119] The preparation method comprises the following steps:

[0120] a. Magnolia officinalis extraction

[0121] a1. Crush Magnolia officinalis into coarse powder, set aside;

[0122] a2. Add the 45% ethanol that is equivalent to Magnolia officinalis weight 4 times in the batching tank; Switch the three-way valve to the batching tank position, open the agitator, diaphragm pump and diaphragm filter press of the batching tank, the 45% ethanol in the batching tank Pump into the membrane filter press (using 5-8 L / m 2 .s polypropylene multifilament filter cloth), until the press filtrate returns to the batching tank, add the magnolia bark powder obtained in step a1 to the batching tank at a constant speed, after adding, the diaphragm filter pres...

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Abstract

The invention discloses a method for preparing ageratum oral liquid. The active ingredients of most of prescription medicinal crops are extracted by using a membrane press filtration, cyclic extraction and separation integrated technology in place of a reflux method, a decoction method and a warm immersion method. A process flow can be simplified, the production period can be greatly shortened, energy can be saved, environmental protection and waste residue utilization can be facilitated, and the recovery rate of the active ingredients can be greatly increased.

Description

technical field [0001] The invention belongs to the field of pharmacy and relates to a preparation method of a traditional Chinese medicine preparation. Background technique [0002] Chinese Pharmacopoeia 2010 Edition One Records: Huoxiang Zhengqi Oral Liquid has the effects of relieving the exterior and removing dampness, regulating qi and harmonizing the middle. It is clinically used for colds caused by exogenous wind-cold, internal injury damp stagnation or summer injury and summer dampness. Symptoms include headache, dizziness, Pain in the chest and diaphragm, distending pain in the abdomen, vomiting and diarrhea; gastrointestinal colds with the above syndromes. The prescription is Atractylodes 80g, Chenpi 80g, Magnolia officinalis (made from ginger) 80g, Angelica dahurica 120g, Poria cocos 120g, Dabupi 120g, raw pinellia 80g, licorice extract 10g, patchouli oil 0.8ml, perilla leaf oil 0.4ml . The preparation method is to add 60% ethanol to Magnolia officinalis, heat a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/889A61K9/08A61P1/00A61P31/12
Inventor 彭涛冯天炯秦少容王文成余佳文魏安国胡中英刘宁骆瑞林
Owner TAIJI GRP CHONGQING FULING PHARM FACTORY CO LTD
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