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A synergist for improving ethambutol's anti-mycobacterial effect

A technology of mycobacteria and ethambutol, which can be used in antibacterial drugs, medical preparations containing active ingredients, and organic active ingredients, etc., can solve the problems of backward research and development of anti-tuberculosis drugs.

Inactive Publication Date: 2011-12-07
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

In the past 30 years, new anti-tuberculosis drugs that can effectively kill drug-resistant strains have not been developed, and the speed of research and development of anti-tuberculosis drugs has lagged far behind the speed at which mycobacteria develop drug resistance

Method used

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  • A synergist for improving ethambutol's anti-mycobacterial effect
  • A synergist for improving ethambutol's anti-mycobacterial effect
  • A synergist for improving ethambutol's anti-mycobacterial effect

Examples

Experimental program
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Embodiment Construction

[0011] References (National Committee for Clinical Laboratory Standards. Susceptibility Testing of Mycobacteria, Nocardiae, and Other Aerobic Actinomycetes: Approved Standard M24-A. NCCLS, Wayne, PA, USA, 2003) and (European Committee for Antimicrobial Susceptibility Testing of the EUCAST) of Clinical Microbiology and Infectious Diseases (ESCMID). Terminology relating to methods for the determination of susceptibility of bacteria to antimicrobial agents. ClinMicrobiol Infect 2000; 6: 503-8.) method, cohesion experiment and efflux experiment, the specific operations are as follows:

[0012] (1) Drug susceptibility test by microdilution method: on a 96-well cell culture plate, serially dilute the drug to be tested by 2 times, inoculate the bacterial solution, incubate at 37°C for 24 hours, observe the results, and calculate the MIC (minimum inhibitory concentration) value

[0013] (2) Checkerboard microdilution experiment: this experiment was carried out in 7H9 / OADC medium, the ...

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Abstract

The invention provides 1-(1-menaphthyl)piperazine which can improve resistance of ethambutol to mycobacterium, wherein, mycobacterium can be mycobacterium tuberculosis or mycobacterium smegmatis.

Description

technical field [0001] The present invention relates to the effect of 1-(1-naphthylmethyl)piperazine on enhancing the anti-mycobacterial activity of ethambutol Background technique [0002] In the long years before the advent of anti-tuberculosis drugs, tuberculosis has been regarded as an incurable disease, which has devoured the lives of countless people. With the advent of anti-TB drugs, the incidence of TB continued to decline, so much so that many people were optimistic that TB would soon be eradicated. However, Mycobacterium tuberculosis quickly developed strong drug resistance to various drugs, causing the outbreak of tuberculosis again. According to the statistics of the World Health Organization (WHO), one-third of the world's population is infected with latent Mycobacterium tuberculosis, of which 50 million people are infected with drug-resistant Mycobacterium tuberculosis. In particular, the emergence and prevalence of multidrug-resistant tuberculosis (MDR-TB) p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/495A61K31/133A61P31/04A61P31/06
Inventor 于录韩文瑜孙长江郭娜金晶梁俊超李蕾
Owner JILIN UNIV
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