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Synthetic method of 2-aryl nitrile thiazole derivatives and intermediates

A compound and bromine technology, applied in the field of heterocyclic chemistry and organic chemistry, can solve the problems of serious equipment corrosion, difficult separation and purification, and difficulty in industrialization, and achieve the effects of reducing reaction costs, simple reaction types, and complete reactions.

Active Publication Date: 2015-08-19
浙江瑞博制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0016] The purpose of the present invention is to overcome the disadvantages of expensive starting raw materials in the above-mentioned prior art, the reagents used are highly toxic, severely corroded equipment, difficult to separate and purify, and difficult to industrialize, and provide a new 2-aryl nitrile thiazole derivative. resolve resolution

Method used

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  • Synthetic method of 2-aryl nitrile thiazole derivatives and intermediates
  • Synthetic method of 2-aryl nitrile thiazole derivatives and intermediates
  • Synthetic method of 2-aryl nitrile thiazole derivatives and intermediates

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Embodiment 1: the preparation of 4-isobutoxybenzonitrile

[0062] Add p-hydroxybenzonitrile (119.0g, 1.0mol) and 400mL N,N-dimethylformamide successively in a 1000ml four-neck round bottom flask, drop into anhydrous potassium carbonate (207.0g, 1.5mol ), sodium iodide (5.0g, 0.03mol) and bromoisobutane (274.0g, 2.0mol), slowly warming up to 80 ~ 85 ℃, stable reaction at this temperature, tracking by TLC during the reaction, until the raw material is completely Transformation takes about 20 hours. After the reaction, filter with suction, rinse the filter cake with 30mL N,N-dimethylformamide, add n-hexane to the obtained solid, extract with 5% aqueous sodium hydroxide solution, combine the organic phases, and concentrate to obtain an orange oil 172.0 g of 4-isobutoxybenzonitrile, the yield was 98.28%, and the HPLC purity was 98.67%.

[0063] 1 H NMR (400 MHz, DMSO) δ 0.99(d, J=5.2 Hz, 6H), 1.99-2.07(m, 1H), 3.83(d, J=5.2 Hz, 2H), 7.09-7.11(m, 2H) , 7.74-7.77(m, 2H). ...

Embodiment 2

[0064] Embodiment 2: the preparation of 4-isobutoxybenzamide

[0065] Add 4-isobutoxybenzonitrile (105.0g, 0.6mol), methanol 600mL and 240.0g 5% NaOH aqueous solution successively in the 2000ml four-necked round bottom flask, heat up to reflux, slowly add 10% hydrogen peroxide 408.0g dropwise under the reflux state, After the dropwise addition was completed, the reaction was continued at this temperature for 8 hours. After the reaction is complete, the reaction system is cooled to 20 to 25° C. by suction filtration, and the filter cake is rinsed with 300.0 g of water, and then dried to obtain 106.5 g of white needle-like crystals 4-isobutoxybenzamide. The yield is 92.00%, HPLC purity 99.87%.

[0066] 1 H NMR (400 MHz, DMSO) δ 0.98(d, J=5.2 Hz, 6H), 1.98-2.06(m, 1H), 3.80(d, J=5.2 Hz, 2H), 6.95-6.98(m, 2H) , 7.1 8(br,1H), 7.82-7.85(m,3H).

Embodiment 3

[0067] Embodiment 3: Preparation of 3-bromo-4-isobutoxybenzamide

[0068] Add 4-isobutoxybenzamide (96.5g, 0.5mol), 600mL dichloroethane and zinc bromide (1.75g, 0.008mol) successively into a 1000ml four-neck round bottom flask, and drop Bromine (88.0 g, 0.55 mol) was added, and after the dropping, the temperature was raised to 65° C. to continue the reaction for 20 hours, and the tail gas was absorbed with 30% NaOH aqueous solution. After the reaction was completed, the reaction was quenched with saturated aqueous sodium bisulfite solution, and the layers were allowed to stand, the organic phase was concentrated, and 250 mL of absolute ethanol was added to the concentrate for recrystallization, and a large amount of white needle-like crystals 3-bromo-4-iso Butoxybenzamide 124.58g, yield 91.60%, HPLC purity 95.71%.

[0069] 1 H NMR (400 MHz, DMSO) δ1.02(d, J=5.2 Hz, 6H), 2.02-2.09(m, 1H), 3.90(d, J=5.2 Hz, 2H), 7.15(d, J=7.2 Hz, 1H), 7.30(br, 1H), 7.86-7.88(m, 1H), 7.93(br,...

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Abstract

The invention relates to the technical field of organic chemistry, in particular to a method for synthesizing 2-aryl nitrile thiazole derivatives and intermediates thereof. In view of the high cost of starting materials in the prior art, the high toxicity of used reagents, serious corrosion to equipment, difficulty in separation and purification, and difficulty in industrialization, the present invention provides a new synthesis method of 2-aryl nitrile thiazole derivatives, the above-mentioned The preparation method uses p-hydroxybenzonitrile as a raw material and undergoes simple types of reactions such as substitution, hydrolysis, electrophilic substitution, nucleophilic substitution, sulfur-oxygen exchange, cyclization, and hydrolysis to obtain 2-aryl nitrile thiazole derivatives. The yield can reach 30%~42%.

Description

technical field [0001] The present invention relates to the technical field of organic chemistry, in particular to the technical field of general methods of heterocyclic chemistry and organic chemistry. Background technique [0002] Febuxostat in 2-aryl nitrile thiazole derivatives, chemical name: 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid, It is a new type of non-purine selective xanthine oxidase inhibitor developed by Japan Teijin Company, and it is mainly used for the treatment of hyperuricemia clinically. [0003] [0004] A lot of research work has been carried out on the preparation of 2-arylnitrile thiazole derivatives. Among the existing synthetic routes, each route has its own uniqueness and also has some shortcomings. At present, the common synthetic routes at home and abroad mainly include the following types. [0005] Route 1: The synthetic route disclosed in Japanese Patent JP10139770 is as follows: [0006] [0007] wherein X is a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D277/56C07C235/46C07C231/12C07C255/57C07C253/14
Inventor 张现毅车大庆
Owner 浙江瑞博制药有限公司
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