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Gujinwan capsule and preparation method thereof

A technology for calcaneal spur and Kashin-Beck disease, applied in the field of Gujinwan capsules and their preparation, can solve the problems of unsatisfactory cure rate, incomplete extraction of active ingredients, and high long-term rebound.

Inactive Publication Date: 2011-12-21
哈药集团三精千鹤制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is used to treat hypertrophic spondylitis, cervical spondylosis and bone spurs, proliferative arthritis, Kashin-Beck disease and other symptoms, but there are deficiencies such as incomplete extraction of active ingredients and low bioavailability. Although some curative effects have been obtained, the cure rate is still low. Ideal, especially high long-term rebound, so people are still looking for a traditional Chinese medicine that can treat bone diseases with better effects and no long-term rebound without toxic side effects

Method used

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  • Gujinwan capsule and preparation method thereof
  • Gujinwan capsule and preparation method thereof
  • Gujinwan capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Take frankincense 6.75g, myrrh 11.5g, white peony root 22.75g, corydalis (vinegar) 6.75g, sanqi 11.5g, woody 6.75g, safflower 11.5g, turmeric 22.75g, duhuo 45.75g, achyranthes bidentata 11.5g g. Gentiana 45.75g, Guizhi 11.5g, dried blood 6.75g, nutmeg (manufactured) 6.75g, the above fourteen flavors, frankincense, myrrh, corydalis, nutmeg, notoginseng, dried blood using a jet mill The extract is crushed into superfine powder a with a particle size of <50 microns (completely passing through a 300 mesh sieve), and mixed evenly; turmeric, woody, lovage, and cassia twigs are enzymolyzed with 50% ethanol with cellulase, and the amount of ethanol is 5 times the amount of medicinal materials, the enzymolysis temperature is 30°C, the pH value is 3, the enzyme dosage is 5mg / g, the enzymolysis time is 0.5h, and the deqing ointment b is added with the four flavors of Radix Paeoniae Alba, Safflower, Achyranthes bidentata, and Gentiana Carbon dioxide supercritical extraction method ...

specific Embodiment 2

[0026] Take 20.25g of frankincense, 34.5g of myrrh, 68.25g of white peony root, 20.25g of Corydalis (made with vinegar), 34.5g of notoginseng, 20.25g of woody fragrance, 34.5g of safflower, 68.25g of turmeric, 137.25g of unihuo, and 34.5g of Achyranthes bidentata. g. Gentiana 137.25g, Guizhi 34.5g, dried blood 20.25g, nutmeg (manufactured) 20.25g, the above fourteen flavors, frankincense, myrrh, corydalis, nutmeg, notoginseng, dried blood using a jet mill The extract is crushed into superfine powder a with a particle size of <50 microns (completely passing through a 300 mesh sieve), and mixed evenly; turmeric, woody incense, lovage, and cassia twig are enzymolyzed with 70% ethanol with cellulase, and the amount of ethanol is 9 times the amount of medicinal materials, the enzymolysis temperature is 50°C, the pH value is 5, the enzyme dosage is 15mg / g, and the enzymolysis time is 3h, to get clear ointment b. Carbon dioxide supercritical extraction method extraction, extraction p...

Embodiment 3

[0028]Take frankincense 13.5g, myrrh 23g, white peony root 45.5g, corydalis (vinegar) 13.5g, notoginseng 23g, woody fragrance 13.5g, safflower 23g, turmeric 45.5g, duhuo 91.5g, achyranthes bidentata 23g, genus chinensis 91.5g g, 23g of Guizhi, 13.5g of dried blood, 13.5g of Nuxychnium (manufactured), the above fourteen flavors, frankincense, myrrh, corydalis, nux. Ultrafine powder a with a particle size of <50 microns (completely passed through a 300-mesh sieve), mixed evenly; turmeric, woody, lovage, and cassia twigs are enzymatically hydrolyzed with 60% ethanol with cellulase, and the amount of ethanol is 7 times the amount of medicinal materials , the enzymolysis temperature is 40°C, the pH value is 4, the enzyme dosage is 10mg / g, and the enzymolysis time is 2h, to obtain clear ointment b, add the four flavors of Radix Paeoniae Alba, Safflower, Achyranthes bidentata, and Gentiana using carbon dioxide supercritical extraction method Extraction, extraction pressure 35Mpa, ext...

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Abstract

The invention discloses a preparation method of traditional Chinese medicine for treating hypertrophic spondylitis, cervical spondylosis, heel spurs, proliferative arthritis and Kashin-Beck disease. The frankincense, myrrh, Corydalis Corydalis, Nuxystigma chinensis, notoginseng and dried blood are crushed by airflow The machine crushes the extract into superfine powder a, and mixes it evenly; the turmeric, woody, solitary, and cassia twigs are enzymatically hydrolyzed to obtain a clear paste b, and the dregs are added to the four flavors of white peony root, safflower, achyranthes bidentata, and Gentiana chinensis. The supernatant c obtained by carbon dioxide supercritical extraction method, b and c are combined, concentrated to a thick paste and dried, and the extract is crushed into ultrafine powder d with a jet mill, and a and d are mixed evenly, and added to a pharmaceutically acceptable The accepted excipients are mixed and encapsulated, and the invention has the advantages of complete extraction of active ingredients, high bioavailability, good absorption, stable quality, good reproducibility and the like.

Description

A technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a Gujinwan capsule for treating hypertrophic spondylitis, cervical spondylosis and spurs, proliferative arthritis and Kashin-Beck disease and a preparation method thereof. Two background technology [0002] Gujin Wan Capsule, promotes blood circulation and removes blood stasis, dispels wind and relieves pain. It is used to treat hypertrophic spondylitis, cervical spondylosis and bone spurs, proliferative arthritis, Kashin-Beck disease and other symptoms, but there are deficiencies such as incomplete extraction of active ingredients and low bioavailability. Although some curative effects have been obtained, the cure rate is still low. Ideal, especially high long-term rebound, so people are still looking for a Chinese medicine that can treat bone diseases better, and has no toxic side effects without long-term rebound. Three invention content [0003] In order to o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/48A61P19/08A61P19/02
Inventor 孙开敬武凤梅郑玉梅费建军朱文军李尚晏尹逊录
Owner 哈药集团三精千鹤制药有限公司
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