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Microparticle sorting apparatus and method, microchip and microchip module

A microchip, particle technology, applied in the direction of individual particle analysis, particle and sedimentation analysis, chemical instruments and methods, etc., can solve the problems of sample cross-contamination, cross-contamination, obstacles, etc.

Active Publication Date: 2015-05-13
SONY CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For this reason, there is the potential for sample cross-contamination between assays, even if the flow meter parts or assemblies and the orifice parts or assemblies are adequately cleaned each time an assay is performed
This cross-contamination of samples between assays, as well as the application of expensive flowmeters and orifice parts or assemblies, is especially a big obstacle in the case of regenerative medicine where stem cells sorted by cell sorters etc. are used

Method used

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  • Microparticle sorting apparatus and method, microchip and microchip module
  • Microparticle sorting apparatus and method, microchip and microchip module
  • Microparticle sorting apparatus and method, microchip and microchip module

Examples

Experimental program
Comparison scheme
Effect test

no. 1 approach

[0103] (1-1) Sample channel

[0104] First, refer to Figure 6 to Figure 9 A first embodiment of the microchip 1 is described. Figure 6 is a perspective view showing a schematic structure of the microchip 1 . A sample inlet 15 , a sheath inlet 14 , and a charging electrode inlet 20 are formed in the microchip 1 . In this case, the sample liquid is guided to the sample inlet 15 . The sheath fluid is directed to the sheath inlet 14 . Then, a charging electrode (charging portion) immersed in the sheath liquid is inserted into the charging electrode inlet 20 . After the sheath fluid introduced into the sheath inlet 14 has flowed into the charging electrode inlet 20 , the sheath fluid is divided into two directions, ie, a Y-axis positive direction and a Y-axis negative direction, to be fed through the sample flow channel 11 . And, after each of the sheath liquids has turned back twice at about 90°, the two join to be fed downstream.

[0105] (1-2) Suction runner

[0106] A ...

no. 2 approach

[0142] (2-1) Changing the flow channel and microtube

[0143] Next, we will refer to Figure 10A and 10B as well as Figure 11 A second embodiment of the microchip 101 is described.

[0144] The microchip 101 has the same structure as the first embodiment of the microchip 1 with respect to the sample flow path, the suction flow path, the microtube, the narrowed flow path, and the light irradiation portion except for the changing flow path and the microtube. For this reason, hereinafter, only a description will be given about the structures of the changing flow channels and the microtubes of the microchip 101 .

[0145] Figure 10A and 10B Each is a schematic cross-sectional view, each for explaining the structure of the sample flow channel 11 near the hole 12 and the variable flow channel 13, and the appearance of the sample liquid laminar flow and the sheath liquid laminar flow that are forced to flow. here, Figure 10A is a horizontal cross-sectional view (XY cross-se...

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PUM

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Abstract

Disclosed herein is a microchip including a substrate and a sample flow path within the substrate. The sample flow path includes a changing flow path and a microtube connected to the changing flow path. The changing flow path is configured to change a cross sectional shape of the sample flow path from a quadrangular shape at a first end to a circular shape at a second end. The microtube is connected to the second end of the changing flow path and is disposed within the substrate.

Description

[0001] References to related applications [0002] This application claims priority from Japanese Priority Patent Application JP 2010-106802 filed with the Japan Patent Office on May 6, 2010, the entire contents of which are hereby incorporated by reference. technical field [0003] The invention relates to a particle sorting device, a microchip, and a microchip module. More specifically, the present invention relates to a method for discharging liquid droplets containing particles after detecting the characteristics of particles flowing through a flow channel formed in a microchip, and controlling the moving direction of the liquid droplets according to the characteristics of the particles, thereby separating Particle sorting equipment, microchips, and microchip modules for particle selection. Background technique [0004] Heretofore, an apparatus for introducing a dispersion liquid of microparticles into a flow channel to optically measure the characteristics of the micro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B07C5/34G01N15/00
CPCB01L3/0268B01L3/502715B01L3/502761B01L3/502776B01L9/527B01L2200/141B01L2300/0816B01L2300/0887B01L2300/089B01L2400/0415B01L2400/049G01N15/1404G01N15/1484G01N2015/1418G01N15/149G01N15/14G01N33/483G01N35/00G01N35/08
Inventor 篠田昌孝松井健辻明子山崎刚秋山昭次
Owner SONY CORP