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Culture system for simulating microgravity effect of suspension cells

A technology of microgravity effect and suspended cells, which is applied in the cultivation device of tissue cells/viruses, the method of stress stimulating the growth of microorganisms, and the bioreactor/fermenter for specific purposes, etc., which can solve the problems of no incubator and achieve The effect of online observation

Inactive Publication Date: 2012-01-25
INST OF MECHANICS - CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In addition, in order to monitor the suspension state of cells in the incubator and the growth shape of cells during the experiment, the rotary culture system requires online observation, but there is no incubator that can be observed online

Method used

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  • Culture system for simulating microgravity effect of suspension cells
  • Culture system for simulating microgravity effect of suspension cells
  • Culture system for simulating microgravity effect of suspension cells

Examples

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Embodiment Construction

[0026] Such as figure 1 , 2 As shown, the present invention includes: a base 1 , a rotating support 2 , a driving rotation part 3 , an incubator 4 and an observation part 5 . The two ends of the rotating bracket 2 are rotatably mounted on the base 1 through the first hollow shaft 21 and the second hollow shaft 22 respectively, and the first rotating seal rotating coaxially with the rotating bracket 2 is installed on the end of the first hollow shaft 21. The joint 23 is installed at the end of the second hollow shaft 22 with a second rotary sealing joint 24 coaxially rotating with the rotating bracket 2 . The driving rotating part is mounted on the base 1 and is used to drive the rotating bracket 2 to rotate at a predetermined rotation speed. The incubator 4 is arranged on the rotating support 2 and has a cavity for containing cell culture fluid. The incubator 4 of the embodiment of the present invention is oblate cylindrical, and one end face of the incubator 4 is provided ...

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Abstract

The invention discloses a culture system for simulating a microgravity effect of suspension cells. The culture system comprises a base, a rotating support, a driving rotating part, an incubator and an observation part, wherein the rotating support is arranged on the base in a rotatable way; the driving rotating part is arranged on the base and is used for driving the rotating support to rotate atthe preset rotating speed; the incubator is arranged on the rotating support and is provided with a cavity for accommodating a cell culture fluid; and the observation part is arranged on the rotatingsupport and is used for observing the state of cells which suspend in the culture fluid in the incubator on line. By arranging the observation part on the rotating support, when the rotating support rotates at the preset rotating speed, the state of the cells which suspend in the culture fluid accommodated in the incubator can be observed on line under the effect of microgravity simulation, so that the on-line observation is realized.

Description

technical field [0001] The invention relates to an experimental device for simulating the microgravity effect of cells, in particular to a culture system for simulating the microgravity effect of suspended cells. Background technique [0002] Microgravity cell biology research is an important content and link of space life science research. Due to the high cost of conducting space experiments and the scarcity of opportunities, it is essential to use ground simulation equipment for experimental program screening and some comparative studies. [0003] The simulation of cell microgravity effects using a rotating incubator is an important research method that can be implemented in ordinary laboratories. The basic principle of the rotating incubator is to rotate the incubator around the horizontal axis at a specific speed, so that the vector sum of the gravity felt by the cells is zero in one rotation cycle, thereby producing some biological effects similar to those under microg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M3/02C12M1/34
CPCC12M35/04C12M41/40
Inventor 龙勉孙树津高宇欣李展陈娟
Owner INST OF MECHANICS - CHINESE ACAD OF SCI
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