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Preparation method of Gandakang capsules

A technology of Gandakang and capsules, which is applied in the field of preparation of traditional Chinese medicine, can solve the problems of large dosage of the original medicine, and achieve the effect of protecting the liver cell membrane, reducing the degree of damage, and good curative effect

Active Publication Date: 2012-02-01
吉林敖东生物科技股份有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The invention provides a preparation method of Gandakang Capsules to solve the problem of large dosage of the original drug

Method used

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  • Preparation method of Gandakang capsules
  • Preparation method of Gandakang capsules
  • Preparation method of Gandakang capsules

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Embodiment

[0022] Prescription: 160g of vinegar-roasted Bupleurum, 160g of vinegar-roasted white peony root, 160g of wine-fried angelica, 160g of madder, 160g of bran-fried Atractylodes macrocephala, 160g of poria, 160g of vinegar-roasted turtle shell, 160g of Xiangqu, 240g of codonopsis, 240g of codonopsis root, 240g of bran-fried hovenia citrus 96g real, 80g fried green skin with bran, 48g amomum, 48g fried earthworm, 48g licorice;

[0023] (1) The above fifteen flavors, vinegar-roasted bupleurum, wine-roasted angelica, bran-roasted citrus aurantium, bran-roasted green skin, bran-roasted Atractylodes macrocephala, amomum soaked in 10 times the amount of water for 4 hours, distilled for 5 hours, and the volatile oil was made into 50% Anhydrous ethanol solution, added to 40°C saturated aqueous solution of β-cyclodextrin, oil: β-cyclodextrin: water = 1:4:100, stirred at 40°C for 2 hours, 300 rpm, at 4°C Refrigerate for 24 hours, filter with suction, dry the precipitate under reduced press...

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Abstract

The invention relates to a preparation method of Gandakang capsules, and belongs to the preparation method of traditional Chinese medicines. According to the invention, after a new process is determined, through study and dynamic detection of three batches of pilot-scale products, the character identification of the product and thin layer identification of four medical materials are determined, and an HPLC (high-performance liquid chromatography) measuring method for peoniflorin content is also built; and according to the above quality standards, the feeding process, and processing steps from the intermediate processing to finished product processing are effectively controlled in the improved production process of the Gandakang capsules, thus the product quality is guaranteed. The Gandakang capsules has the effects of obviously resisting aminotransferase increase caused by CCl4 and D-galactosamine, relieving the degree of liver injury caused by chemical substances, and protecting liver cell membrane; and the Gandakang capsules also has the effects of improving phagocytosis function of mice and the generation of antibody for mouse hemolysin caused by sheep erythrocyte, thus the product can better improve mouse immune function, and the new dosage form of Gandakang capsules has good liver protection effect and has better treatment effect if applied clinically.

Description

technical field [0001] The invention belongs to the preparation method of traditional Chinese medicine. Background technique [0002] Gandakang Capsule is one of the main products of our company. It has been favored by liver disease patients for many years because of its definite curative effect and moderate price. The original dosage form of this preparation is capsules. Prescription: Bupleurum (stir-fried with vinegar) 160g, Radix Paeoniae Alba (fried with vinegar) 160g, Angelica (stir-fried with wine) 160g, Rubia 160g, Atractylodes macrocephala (stir-fried with bran) 160g, Poria cocos 160g, Turtle shell (stir-fried with vinegar) Sunburn) 160g, Xiangqu 160g, Codonopsis 240g, Imperatae 240g, Citrus aurantium (stir-fried with bran) 96g, green skin (stir-fried with bran) 80g, amomum 48g, earthworm (stir-fried) 48g, licorice 48g; it has been clinically used for many years, and the curative effect Good, fast absorption, easy to carry, but the patient reported a large dosage (8...

Claims

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Application Information

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IPC IPC(8): A61K36/9064A61P1/16A61K35/36A61K35/64A61K35/586A61K35/62
Inventor 王永宽刘全李伟苗春雷王玉宝关殿朋于胜涵
Owner 吉林敖东生物科技股份有限公司
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