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Seaweed polysaccharide medicinal plant film coating and preparation method thereof

A technology of film coating and seaweed polysaccharide, applied in pharmaceutical formulations, medical preparations of inactive ingredients, etc., can solve problems such as complication, and achieve the effects of less weight gain, faster drying, and improved dissolution.

Inactive Publication Date: 2012-02-08
INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, many pharmaceutical companies still have many problems in the application due to the complexity of drug coating raw materials and technical reasons for preparation.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Preparation of seaweed polysaccharide medicinal plant film coating:

[0025] 21kg of pharmaceutical grade seaweed polysaccharide, 30kg of pharmaceutical grade dietary plant fiber (purchased from Shandong) are put into 250-300kg stainless steel stirring pot with insulation layer and stirrer and outlet, and stir while slowing down for at least 3 minutes. Slowly add 200kg of hot water at 80°C and stir thoroughly for 2-4 hours until the temperature drops to 50°C. When the solution is transparent, start the heat preservation facility to keep the temperature at 50°C.

[0026] Add 0.5kg of fucoidan to another 200kg stirring pot with the same capacity as the above conditions, and add 100kg of warm water at 25°C, stir well for 2-4 hours until the solution is transparent, and add 100- 200mg of food coloring, continue to stir for 1 hour to ensure the reaction balance of the glue and eliminate a large number of bubbles generated by stirring.

[0027] Put the above two pots of mate...

Embodiment 2

[0029] Add 200kg of hot water at 80°C to a stainless steel mixing pot with a capacity of 250kg-300kg, equipped with an insulating layer, a stirrer, and an outlet. While stirring, add 15kg of pharmaceutical grade seaweed polysaccharide and 42kg of dietary plant fiber, and stir thoroughly for 3- 5 hours, until the temperature drops to 55°C and the solution is transparent, start the heat preservation facility to keep the temperature at 55°C.

[0030] In another 100kg stirring pot with the same capacity as the above conditions, first add 50kg of cold water, then add 3kg of pharmaceutical grade modified starch (purchased from Jiangsu), stir fully for 2-4 hours, then add 50kg, 90 ℃ hot water and adjust the temperature to 60°C, continue to keep warm and stir for 1 hour, keep warm for 20 minutes and set aside.

[0031] Put the above two pots of materials from the outlet into a stainless steel storage tank with heat preservation facilities and can be connected to a high-efficiency coat...

Embodiment 3

[0033] Add 33kg of pharmaceutical grade seaweed polysaccharide, add 200kg of 90°C hot water, in a stainless steel stirring pot with insulation layer, agitator and material outlet, keep warm and stir for 1 hour until the solution is transparent. Disconnect the heat preservation equipment and let it rest naturally for 2 hours, keeping the temperature of the solution at 60-70°C.

[0034] Guar gum 0.2kg, add 100kg of warm water at 20-25°C, stir evenly, after standing still for 30 minutes, continue stirring for 10 minutes, mix with the above seaweed polysaccharide solution and continue stirring evenly, keep the mixing temperature at 48-50°C, as a package Spray coating is carried out within 1-2 hours for the ready-made coating spray.

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PUM

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Abstract

The invention relates to a drug tablet core coating technology, and specifically, relates to a seaweed polysaccharide medicinal plant film coating and a preparation method thereof. The seaweed polysaccharide medicinal plant film coating comprises a component A, a component B, and a water solvent, wherein the component A comprises seaweed polysaccharide and / or dietary vegetable fibers and the component B comprises one or more of modified starch, guar gum, edible pigment and brown seaweed polysaccharide. Specifically, the seaweed polysaccharide medicinal plant film coating comprises 5 to 15 wt% of the seaweed polysaccharide, 9 to 16 wt% of the dietary vegetable fibers, 1 to 3 wt% of the modified starch, 0.5 to 0.1 wt% of the guar gum, 0.1 to 1 wt% of the brown seaweed polysaccharide, based on the total weight of the seaweed polysaccharide medicinal plant film coating, 0.1 to 0.5ppm of the edible pigment, and the balance the water solvent. A film forming agent and the most of auxiliary additives adopted by the preparation method of the seaweed polysaccharide medicinal plant film coating are all high-molecular materials with excellent physiochemical performances. Therefore, after coating, the seaweed polysaccharide medicinal plant film coating has the effects of proofing moisture, avoiding light, covering peculiar smell and resisting wear, is difficult to mildew, is easy for disintegration, and improves greatly a drug dissolution rate, bioavailability and a period of drug validity.

Description

technical field [0001] The invention relates to seaweed polysaccharide drug tablet core coating technology, in particular to seaweed polysaccharide medicinal plant film coating and a preparation method thereof. Background technique [0002] Pharmaceutical coating is to spray a thin film with good stability on the tablet embryos pressed from raw materials to cover up the taste of the drug tablet itself and increase the stability of the tablet, avoiding chemically active drugs and other substances Deterioration due to chemical reaction, etc. The coating material is also a pharmaceutical excipient controlled and supervised by the national SFDA. [0003] The traditional coating technology is sugar coating, and its main auxiliary material is talcum powder. Sugar-coated tablets using talc powder can increase the weight of the drug tablet core by 50%-100%, causing patients to take a large amount of drugs that have nothing to do with the drug ingredients. Accessories. [0004] In...

Claims

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Application Information

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IPC IPC(8): A61K47/38A61K47/36C08L1/02C08L5/04C08L3/04
Inventor 韩丽君袁毅唐连德郭书举李宪璀邢荣娥李婷
Owner INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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