Treatment of neurotrophic factor mediated disorders

A neurotrophic factor, disease technology, applied in nervous system diseases, skin diseases, allergic diseases, etc., can solve problems such as limiting potential utility

Inactive Publication Date: 2012-02-15
PHYTOPHARM LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This severely limits the potentia

Method used

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  • Treatment of neurotrophic factor mediated disorders
  • Treatment of neurotrophic factor mediated disorders
  • Treatment of neurotrophic factor mediated disorders

Examples

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Embodiment Construction

[0048] introduction

[0049] The evidence presented in this application shows that the agent does not bind to many receptors and enzymes (see Example 1).

[0050] This application presents evidence supporting the effect of active agents on inducing NF or NF-receptors. The evidence (see Examples 2 and 3 below) shows that activity includes enhancing the expression of NF and NF-receptor genes. As can be seen in Example 2, wherein the neurons are relatively healthy (basal medium). The enhanced gene expression is transient and the time scale strongly indicates the involvement of self-regulatory mechanisms.

[0051] In the more unsound situation of Example 3, the data shows a much longer period of enhanced gene expression, showing that the regulatory mechanism remains intact and the degree of enhancement of gene expression depends on the needs of the system.

[0052] The evidence presented in this application also shows that the active agent provides the homeostasis of the self-regulatio...

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Abstract

An agent selected from A/B-cis furostane, furostene, spirostane and spirostene steroidal sapogenins and ester, ether, ketone and glycosylated forms thereof is used to induce self- regulated homeostasis of neurotrophic factors(NFs), for example BDNF and/or GDNF, NFs with limited and manageable side effects in a subject, by modulating NFs in a non- toxic manner under homeostatic control. An effective amount of at least one such agent is administered to the subject, particularly in the treatment or prevention of a range of NF- mediated disorders, particularly neurological, psychiatric, inflammatory,allergic,immune and neoplastic disorders, and in the restoration or normalisation of neuronal and other function in or in relation to any damaged or abnormal tissue, including when assisting tissue (for example, skin, bone, eye and muscle) healing and general skin, bone, eye and muscle health.

Description

Invention field [0001] The present invention relates to the treatment and prevention of neurotrophic factor-mediated disorders, especially neurological, psychiatric, inflammatory, allergic, immunological and neoplastic disorders, and any damage or damage in or in any abnormal tissue Or the restoration or normalization of abnormal tissue-related neurons and other functions, including when assisting tissues (such as skin, bone, eyes, and muscles) to heal and general skin, bone, eye, and muscle health. Non-therapeutic methods and involve compounds and compositions used therein. Background of the invention [0002] Neurotrophic factor (NF) includes neurotrophin, TGF-β-superfamily, NF and ganglion cytokines, such as nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), ciliary ganglion neurotrophic factor (CNTF) ), neurotrophin 3 (NT-3), neurotrophin 4 (NT-4) and glial-derived neurotrophic factor (GDNF). Neurotrophic factors bind to cellular receptors called neurotrop...

Claims

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Application Information

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IPC IPC(8): A61K31/58A61P17/02A61P17/16A61P17/18A61P25/00A61P37/00
Inventor D·里斯安东尼娅·奥尔西帕特里克·豪森夏宗勤胡雅儿
Owner PHYTOPHARM LTD
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