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Self-heated traditional Chinese medicine emplastrum for treating chronic simple rhinitis

A self-heating, traditional Chinese medicine paste technology, applied in the direction of heating equipment for treatment, cooling equipment for treatment, drug combination, etc., can solve the first-pass effect and other problems

Active Publication Date: 2012-03-07
GUANGZHOU NEW DESIGN BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with the existing hard capsules, the solution described in the patent application has improved bioavailability, but there are still shortcomings of the first-pass effect in the existing oral preparations

Method used

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  • Self-heated traditional Chinese medicine emplastrum for treating chronic simple rhinitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Self-heating traditional Chinese medicine plaster group:

[0063] 1. Preparation of plaster:

[0064] Prescription of raw materials: menthol 8g, Xanthium 120g, Huoxiang 80g, Passepartout 120g, Schizonepeta 72g.

[0065] Matrix formula: 31g gelatin, 12g sodium carboxymethylcellulose, 8g polyvinyl alcohol, 88g pressure-sensitive adhesive, 24g carbomer, 250g glycerol, 250g propylene glycol, 5g kaolin, 5g zinc oxide, 9g citric acid, citric acid Sodium 33g, water 285g.

[0066] Preparation of water extract: Take Xanthizi, Huoxiang, Passepartout and Schizonepeta, add water and decoct twice, add 6 times the amount of water for the first time, add 6 times the amount of water for the second time, each time for 1.5 hours, and combine The second decoction is filtered, the filtrate is concentrated to a thick paste with a relative density of 1.28-1.32 (measured at 60°C), dried at 80°C, crushed into fine powder, and sieved to obtain the product.

[0067] Preparation of active ingr...

Embodiment 2

[0075] 1. Preparation of plaster:

[0076] Prescription of raw materials: menthol 6g, Xanthium 74g, Huoxiang 66g, Passepartout 155g, Schizonepeta 99g.

[0077] Matrix formula: 37g gelatin, 14g sodium carboxymethylcellulose, 10g polyvinyl alcohol, 307g glycerol, 306g propylene glycol, 50g polyethylene glycol, 50g butanediol, 6g zinc oxide, 6g micronized silica gel, 29g sodium citrate , aluminum trichloride 8g, water 177g.

[0078] Preparation of water extract: same as Example 1.

[0079] Preparation of active ingredients: adding menthol to the prepared water extract and mixing evenly to obtain Chinese medicine extract powder.

[0080] Preparation of plaster: dissolve the prepared active ingredients in water, add propylene glycol, glycerin, polyethylene glycol and butylene glycol and mix to obtain a mixed solution; dissolve polyvinyl alcohol in 1 / 2 of the above mixed solution, fully swell, Component 1 is obtained; sodium carboxymethyl cellulose is dissolved in 1 / 6 of the abov...

Embodiment 3

[0087] 1. Preparation of plaster:

[0088] Raw material prescription: Menthol 12g, Xanthium 88g, Huoxiang 60g, Passepartout 140g, Nepeta 100g.

[0089] Matrix formula: 40g gelatin, 17g sodium carboxymethylcellulose, 17g methylcellulose, 11g sodium polyacrylate, 11g polyvinyl alcohol, 11g polyvinylpyrrolidone, 125g pressure-sensitive adhesive, 33g carbomer, 156g glycerol, Propylene glycol 156g, micropowder silica gel 8g, citric acid 15g, sodium citrate 27g, water 373g.

[0090] Preparation of water extract: same as Example 1.

[0091] Preparation of active ingredients: adding menthol to the prepared water extract and mixing evenly to obtain Chinese medicine extract powder.

[0092]Preparation of plaster: dissolve the prepared active ingredients in water, add glycerol and propylene glycol and mix to obtain a mixed solution; dissolve polyvinyl alcohol in 1 / 2 of the above mixed solution, and fully swell to obtain component 1; gelatin, carboxylate Sodium methyl cellulose, methyl...

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Abstract

The invention relates to a compound Chinese medicinal preparation, in particular to a self-heated traditional Chinese medicine emplastrum for treating chronic simple rhinitis. The self-heated traditional Chinese medicine emplastrum comprises a sealed bag and a plaster and a self-heated bag which are bound up and down together and packed in the sealed bag, wherein the self-heated bag comprises a ventilating bag and a chemical exothermic material having an iron oxidation reduction reaction and being packed in the ventilating bag; and the plaster comprises a backing layer, a medicament storing warehouse layer and an anti-sticking layer. The self-heated traditional Chinese medicine emplastrum is characterized in that the medicament storing warehouse layer comprises a pharmaceutically acceptable substrate and an effective ingredient of an active pharmaceutical ingredient of which the weight is equivalent to 40% of the weight of the substrate, wherein the effective ingredient comprises 1.5%to 3% of menthol and aqueous extracts of the following active pharmaceutical ingredients in the terms of the weight percentage of the active pharmaceutical ingredients: 10% to 60% of achene of siberian cocklebur, 10% to 30% of wrinkled giant hyssop, 10% to 60% of fructus liquidambaris and 10% to 30% of herba schizonepetae. The self-heated traditional Chinese medicine emplastrum provided by the invention has the advantages of quick effect, good percutaneous absorption and proved treating effect.

Description

field of invention [0001] The invention relates to medical preparations, in particular to a traditional Chinese medicine compound preparation. technical background [0002] Chronic simple rhinitis is a reversible inflammation of nasal mucosa caused by local, systemic or environmental factors. The main pathological changes were autonomic dysfunction in the nasal mucosa, mucosal vasodilation, and increased permeability; lymphocytes and plasma cells infiltrated around the blood vessels and glands; mucus glands were active and secretions increased. The main symptoms are nasal congestion and runny nose. [0003] Chronic simple rhinitis is a common chronic inflammation of nasal mucosa and submucosal inflammation that lasts for more than 4 weeks. The common causes are: repeated episodes of acute rhinitis and the impact of chronic inflammation of adjacent organs; the impact of occupational and environmental factors; excessive smoking and alcohol, long-term fatigue, mental stress, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/538A61K9/70A61F7/03A61P11/02
Inventor 方永奇方惠新刘林薛中锋方若鸣
Owner GUANGZHOU NEW DESIGN BIOTECHNOLOGY CO LTD
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