The invention discloses a
lipid peroxide generator and a preparation method and application of a lipidosome. The
lipid peroxide generator comprises lipid and an
iron source. The preparation method ofthe lipidosome comprises the steps that the
iron source is wrapped by the lipid to form the lipidosome. The lipidosome is taken into and enters
tumor cells through caveolin-mediated
endocytosis, ironions are released in an acid
lysosome environment, an iron oxidation-reduction pair formed in the
cytoplasm can catalyze
lipid peroxidation of unsaturated lipid, accumulation of the
lipid peroxide inthe cells is caused, finally, iron
apoptosis of the
tumor cells is caused, and the aim of treating the tumors is achieved. Through
in vitro representation, it is explained that the lipid
peroxide generator can generate the lipid
peroxide under triggering of the iron oxidation-reduction pair; through anti-tumor activity evaluation on the
cell level and animal
cell, it is proved that the lipid
peroxide generator can generate a large amount of lipid peroxide in the
tumor cells, and iron
apoptosis-mediated tumor treatment is effectively achieved.