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Self-heated traditional Chinese medicine (TCM) emplastrum for treating osteoarthritis

A self-heating technology for osteoarthritis, applied to heating appliances for treatment, cooling appliances for treatment, bone diseases, etc., can solve the problems of slow onset of action and unsatisfactory transdermal absorption effect, and achieve clinical Improvement of symptoms and signs

Active Publication Date: 2013-08-14
GUANGZHOU NEW DESIGN BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although it treats hyperosteogeny and arthritis, and is a kind of external application drug, it is obviously slow to take effect only by body temperature, and the transdermal absorption effect is not ideal

Method used

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  • Self-heated traditional Chinese medicine (TCM) emplastrum for treating osteoarthritis
  • Self-heated traditional Chinese medicine (TCM) emplastrum for treating osteoarthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] 1. Preparation of plaster:

[0081] Prescription of raw materials: 8g borneol, 80g Zhichuan Aconitum, 80g Achyranthes bidentata, 80g Duhuo, 40g cassia twig, and 112g mulberry branch.

[0082] Matrix formula: 31g gelatin, 12g sodium carboxymethylcellulose, 8g polyvinyl alcohol, 88g pressure-sensitive adhesive, 24g carbomer, 250g glycerol, 250g propylene glycol, 5g kaolin, 5g zinc oxide, 9g citric acid, citric acid Sodium 33g, water 285g.

[0083] Preparation of water extract: Take Aconitum Aconiti, Achyranthes bidentata, Duhuo, Guizhi and Sangzhi, add water and decoct twice, add 6 times the amount of water for the first time, add 6 times the amount of water for the second time, each time for 1.5 hours, Combine the two decoctions, filter, concentrate the filtrate to a thick paste with a relative density of 1.28-1.32 (measured at 60°C), dry at 80°C, pulverize into fine powder, and sieve to obtain the product.

[0084] Preparation of active ingredients: add borneol to the...

Embodiment 2

[0092] 1. Preparation of plaster:

[0093] Prescription of raw materials: 6g borneol, 52g Zhichuanwu, 74g Achyranthes bidentata, 95g Duhuo, 74g cassia twig, and 99g mulberry branch.

[0094] Matrix formula: 37g gelatin, 14g sodium carboxymethylcellulose, 10g polyvinyl alcohol, 307g glycerol, 306g propylene glycol, 50g polyethylene glycol, 50g butanediol, 6g zinc oxide, 6g micronized silica gel, 29g sodium citrate , aluminum trichloride 8g, water 177g,

[0095] Preparation of water extract: same as Example 1.

[0096] Preparation of active ingredients: add borneol to the prepared water extract, mix well to obtain Chinese medicine extract powder.

[0097] Preparation of plaster: dissolve the prepared active ingredients in water, add propylene glycol, glycerin, polyethylene glycol and butylene glycol and mix to obtain a mixed solution; dissolve polyvinyl alcohol in 1 / 2 of the above mixed solution, fully swell, Component 1 is obtained; sodium carboxymethyl cellulose is dissolve...

Embodiment 3

[0104] 1. Preparation of plaster:

[0105] Prescription of raw materials: borneol 9g, Aconitum 40g, Achyranthes bidentata 59g, Duhuo 85g, cassia twig 72g, mulberry branch 135g.

[0106] Matrix formula: 40g gelatin, 17g sodium carboxymethylcellulose, 17g methylcellulose, 11g sodium polyacrylate, 11g polyvinyl alcohol, 11g polyvinylpyrrolidone, 125g pressure-sensitive adhesive, 33g carbomer, 156g glycerol, Propylene glycol 156g, micropowder silica gel 8g, citric acid 15g, sodium citrate 27g, water 373g.

[0107] Preparation of water extract: same as Example 1.

[0108] Preparation of active ingredients: add borneol to the prepared water extract, mix well to obtain Chinese medicine extract powder.

[0109] Preparation of plaster: dissolve the prepared active ingredients in water, add glycerol and propylene glycol and mix to obtain a mixed solution; dissolve polyvinyl alcohol in 1 / 2 of the above mixed solution, and fully swell to obtain component 1; gelatin, carboxylate Sodium ...

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Abstract

The invention relates to a traditional Chinese medicine (TCM) compound preparation, in particular to a self-heated TCM emplastrum for treating osteoarthritis. The self-heated TCM emplastrum comprises a sealing bag, a plaster and a self-heated bag, wherein the plaster and the self-heated bag are wrapped in the sealing bag and are bonded together up and down; the self-heated bag comprises an air-permeable bag and chemical heating materials which are wrapped in the air-permeable bag and are used for iron oxidation-reduction reactions; and the plaster comprises a backing layer, a medicine storagelayer and an anti-adhesion layer. The emplastrum is characterized in that the medicine storage layer comprises a pharmaceutically acceptable matrix and active ingredients of active pharmaceutical ingredients; and the active ingredients account for 40% of the matrix by weight and comprise 1.5-3% of borneol and aqueous extracts of the following active pharmaceutical ingredients according to the weight percent of the active pharmaceutical ingredients: 10-40% of radix aconiti preparata, 10-40% of radix achyranthis bidentatae, 10-40% of radix angelicae pubescentis, 10-25% of cassia twig and 15-40%of mulberry twig. The self-heated TCM emplastrum has the advantages of high effect taking speed, good percutaneous absorption and definite curative effect.

Description

field of invention [0001] The invention relates to medical preparations, in particular to a traditional Chinese medicine compound preparation. technical background [0002] Osteoarthritis is a kind of articular cartilage degeneration, new bone formation under the cartilage and around the joints, pain that aggravates when bearing weight, articular cartilage wear and disappear, bone hyperplasia, resulting in joint deformity, joint friction noise during activities, Local tenderness and mild swelling of the joints are the main manifestations of the disease. The traditional Chinese medical science includes this disease in the category of "Bone Arthralgia". It is believed that its onset is nothing more than exogenous wind-cold-damp evil, internal injury caused by insufficient liver and kidney, loss of Qi and blood, or injury from falls, which all make the circulation of Qi and blood poor, and the collaterals are blocked. Cartilage atrophy, dysfunction. At present, modern medici...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/714A61K9/70A61F7/03A61P19/02A61K31/045
Inventor 方永奇方惠新刘林薛中锋方若鸣
Owner GUANGZHOU NEW DESIGN BIOTECHNOLOGY CO LTD
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