Self-heated traditional Chinese medicine (TCM) emplastrum for improving pelvic inflammation

A self-heating, traditional Chinese medicine sticking technology, which is applied to heating appliances for treatment, drug combinations, and pharmaceutical formulas, etc., which can solve the problems of unsatisfactory transdermal absorption effect and slow onset of effect

Active Publication Date: 2012-03-07
高康日化集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although the medicine is externally applied, it is obviously slow to take effect only by body temperature, and the transdermal absorption effect is not satisfactory.

Method used

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  • Self-heated traditional Chinese medicine (TCM) emplastrum for improving pelvic inflammation
  • Self-heated traditional Chinese medicine (TCM) emplastrum for improving pelvic inflammation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] 1. Preparation of plaster:

[0047] Prescription of raw materials: borneol 8g, holly hair 76g, rhubarb 56g, dandelion 60g, flavescens 80g, red peony 60g, blanc 60g.

[0048] Matrix formula: 31g gelatin, 12g sodium carboxymethylcellulose, 8g polyvinyl alcohol, 88g pressure-sensitive adhesive, 24g carbomer, 250g glycerol, 250g propylene glycol, 5g kaolin, 5g zinc oxide, 9g citric acid, citric acid Sodium 33g, water 285g.

[0049] Preparation of the water extract: take holly holly, rhubarb, dandelion, flavescens, red peony root and blanc blanc and decoct twice, add 6 times the amount of water for the first time, and add 6 times the amount of water for the second time, each time After 1.5 hours, the second decoction was combined, filtered, and the filtrate was concentrated to a thick paste with a relative density of 1.28-1.32 (measured at 60°C), dried at 80°C, crushed into fine powder, and sieved to obtain the product.

[0050] Preparation of active ingredients: add borne...

Embodiment 2

[0058] 1. Preparation of plaster:

[0059] Prescription of raw materials: borneol 7g, holly hair 40g, rhubarb 45g, dandelion 61g, flavescens 110g, red peony 76g, blanc 61g.

[0060] Matrix formula: 37g gelatin, 14g sodium carboxymethylcellulose, 10g polyvinyl alcohol, 307g glycerol, 306g propylene glycol, 50g polyethylene glycol, 50g butanediol, 6g zinc oxide, 6g micronized silica gel, 29g sodium citrate , aluminum trichloride 8g, water 177g.

[0061] Preparation of water extract: same as Example 1.

[0062] Preparation of active ingredients: add borneol to the prepared water extract, mix well to obtain Chinese medicine extract powder.

[0063] Preparation of plaster: dissolve the prepared active ingredients in water, add propylene glycol, glycerin, polyethylene glycol and butylene glycol and mix to obtain a mixed solution; dissolve polyvinyl alcohol in 1 / 2 of the above mixed solution, fully swell, Component 1 is obtained; sodium carboxymethyl cellulose is dissolved in 1 / 6 ...

Embodiment 3

[0070] 1. Preparation of plaster: borneol 8g, holly hair 76g, rhubarb 56g, dandelion 60g, flavescens 80g, red peony 60g, blancia 60g.

[0071] Prescription of raw materials: borneol 8g, holly hair 67g, rhubarb 32g, dandelion 46g, flavescens 75g, red peony root 94g, blancia 78g.

[0072] Matrix formula: 40g gelatin, 17g sodium carboxymethylcellulose, 17g methylcellulose, 11g sodium polyacrylate, 11g polyvinyl alcohol, 11g polyvinylpyrrolidone, 125g pressure-sensitive adhesive, 33g carbomer, 156g glycerol, Propylene glycol 156g, micropowder silica gel 8g, citric acid 15g, sodium citrate 27g, water 373g.

[0073] Preparation of water extract: same as Example 1.

[0074] Preparation of active ingredients: add borneol to the prepared water extract, mix well to obtain Chinese medicine extract powder.

[0075] Preparation of plaster: dissolve the prepared active ingredients in water, add glycerol and propylene glycol and mix to obtain a mixed solution; dissolve polyvinyl alcohol in...

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Abstract

The invention relates to a traditional Chinese medicine (TCM) compound preparation, and in particular relates to a self-heated TCM emplastrum for improving pelvic inflammation. The emplastrum comprises a sealing bag, a plaster and a self-heated bag, wherein the plaster and the self-heated bag are wrapped in the sealing bag and are bonded together up and down; the self-heated bag comprises an air-permeable bag and chemical heating materials which are wrapped in the air-permeable bag and carry out iron oxidation-reduction reactions; and the plaster comprises a backing layer, a medicine storage layer and an anti-adhesion layer. The emplastrum is characterized in that the medicine storage layer comprises a pharmaceutically acceptable matrix and active ingredients of active pharmaceutical ingredients; the active ingredients account for 40% of the matrix by weight and comprise 1.5-3% of borneol and aqueous extracts of the following active pharmaceutical ingredients according to the weight percent of the active pharmaceutical ingredients: 10-40% of pubescent holly root, 8-25% of rheum officinale, 8-25% of dandelion, 10-30% of radix sophorae flavescentis, 8-25% of red paeony root and 8-25% of cowherb seed. The emplastrum has the advantages of quick effect, good percutaneous absorption and definite curative effect.

Description

field of invention [0001] The invention relates to medical preparations, in particular to a traditional Chinese medicine compound preparation. technical background [0002] Pelvic inflammatory disease is a gynecological disease mainly manifested by pain in the lower abdomen or lower abdomen, refusal to press or swelling, leading to the lumbosacral area, or accompanied by fever, and increased leucorrhea. There is no record of the name of pelvic inflammatory disease in Chinese medicine, but according to its clinical manifestations, it can be summarized as "heat entering the blood chamber", "leukorrhagia", and "female abdominal pain". "Irregular menstrual flow", "dysmenorrhea", "infertility" and other diseases. For example, [Women’s Good Prescriptions] contains: “A woman’s menstrual cramps are blocked. Or the postpartum surplus is not exhausted, so she takes advantage of the wind to get cool, and is taken advantage of by the wind cold. If the blood is cold, it is also congesti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61K9/70A61F7/03A61P15/00
Inventor 方永奇方惠新刘林薛中锋方若鸣
Owner 高康日化集团有限公司
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