Compound oil-in-water cnidium fruit oil nanoemulsion composition and preparation method thereof
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A technology of cnidium oil and oil-in-water type, which is applied in the field of medicine, can solve the problems that affect the promotion and use of cnidium oil, the bioavailability of drugs is not high, and the drug properties have not been fully exerted, so as to achieve good transdermal efficacy and improve biological Usability and stability improvement effect
Inactive Publication Date: 2012-04-04
NORTHWEST A & F UNIV
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[0005] At present, people's utilization of Cnidium oil is mainly limited to the original drug. Although the original drug has a certain curative effect, its external skin penetration rate is low, the drug bioavailability is not high, it
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Embodiment 1
[0059] A compound oil-in-water type cnidium oil nanoemulsion composition, the quality of each component:
[0060] Cnidium seed oil 3.5g, eugenol 3.2g, amitraz 0.5g, polyoxyethylene ether (40) hydrogenated castor oil 26.6g, ethanol 0.1g, distilled water 66.1g, the above components are made into compound oil-in-water snake Bed seed oil nanoemulsion composition, comprises the following steps:
[0061] 1) Accurately weigh the quality of cnidium oil, eugenol, amitraz, polyoxyethylene ether (40), hydrogenated castor oil, ethanol, and distilled water according to the formula, and set aside;
[0062] 2) Mix and stir the said amount of cnidium oil and eugenol evenly as the oil phase;
[0063] 3) Add the amount of amitraz into the oil phase, and stir evenly until the amitraz is dissolved, then add the amount of ethanol and stir well, at this time, the amitraz will completely dissolve in the oil phase;
[0064] 4) Add the amount of polyoxyethylene ether (40) hydrogenated castor oil...
Embodiment 2
[0067] A compound oil-in-water type cnidium oil nanoemulsion composition, the quality of each component:
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Abstract
The invention discloses a compound oil-in-water cnidium fruit oil nanoemulsion composition. The particle size of the nanoemulsion composition is between 1 nm and 100nm. The nanoemulsion composition comprises the following raw materials in percentage by mass: 0.1 to 9.0 percent of cnidium fruit oil, 0.1 to 3.5 percent of eugenol, 0.1 to 2.0 percent of amitraz, 20.0 to 35.0 percent of surfactant, 0.1 to 6.0 percent of cosurfactant and the balance of distilled water, wherein the total percentage by weight of the raw materials is 100 percent. The compound cnidium fruit oil nanoemulsion has the effects of killing pests, relieving itching and killing bacteria and can be applied to the treatment of parasites (such as sarcoptic mites, psoroptidae, ticks, lice and the like) on body surfaces of animals. Through the compound oil-in-water cnidium fruit oil nanoemulsion composition, the stability and the bioavailability of the medicament are improved, the dosage of the medicament is reduced, the permeability is high, the insecticidal range is wide, the effect is obvious, and the preparation method is simple. Therefore, the compound oil-in-water cnidium fruit oil nanoemulsion composition is convenient to popularize and has wide market prospect in the field of medicaments.
Description
technical field [0001] The invention belongs to the field of medicine, and relates to a compound oil-in-water type cnidium oil nanoemulsion composition and a preparation method thereof, which can be used for treating animal epiparasites (such as scabies mites, itch mites, ticks, lice, etc.). Background technique [0002] Mites, ticks, lice, etc. are common surface parasites in veterinary clinics. They often cause flushing, rash-like nodules on the skin surface of animals, local hair loss, inflammation, secretions and scabs. Animals are extremely itchy and restless , Scratching, biting, rubbing the affected skin. Although simple ectoparasitic diseases do not cause the death of animals, they seriously affect the quality of life and production performance of animals, especially when infected with pathogenic bacteria, fungi, viruses and other pathogens, it may be life-threatening. Some parasites are zoonotic and pose a threat to human health. Therefore, this disease cannot be ...
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