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Technique for extracting resveratrol and pigment from grape skin

A technology of resveratrol and grape skin, which is applied in chemical instruments and methods, preparation of organic compounds, azo dyes, etc., can solve the problems of large influence of extraction medium product components, high investment and operating costs, and extraction process consumption. Time and other issues, to achieve the effect of reducing extraction cost, low extraction cost, and short extraction time

Active Publication Date: 2014-12-03
GANSU SHOULUSHAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the methods for extracting resveratrol or pigments from grape skins mainly include solvent extraction, supercritical CO 2 Extraction method, microwave extraction method, etc., the main problems in the above methods are as follows: 1. The solvent extraction method mainly has a lot of organic solvent consumption, the extraction process is time-consuming, and the production cost is high. Solvent remains in the obtained product. The leakage of the solvent during the process will cause problems such as poor extraction environment and environmental pollution. If the leakage of the solvent is controlled, it will inevitably cause a series of problems such as complex production equipment, high investment and operating costs, and increased costs; 2. Supercritical CO 2 The main reason for the extraction method is that the production cost is too high and the requirements for operating conditions are relatively high; 3. The disadvantage of the microwave extraction method is that the selection of the extraction medium has a great influence on the product components, resulting in the loss of some active ingredients
[0004] In the process of extracting resveratrol or pigment in grape skin, the above method still has many problems such as low extraction rate and high energy consumption, and only extracts resveratrol or pigment in grape skin

Method used

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  • Technique for extracting resveratrol and pigment from grape skin
  • Technique for extracting resveratrol and pigment from grape skin
  • Technique for extracting resveratrol and pigment from grape skin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] 1) Grape pomace drying: the grape pomace after recovering the wine liquid is naturally air-dried to remove the remaining moisture until the moisture content is about 3%.

[0023] 2) Pulverization: pulverize the air-dried grape skins to 80 meshes and set aside.

[0024] 3) Ultrasonic extraction of resveratrol: Weigh 2 g of crushed 80-mesh grape skin, add 14 ml of ethyl acetate with a volume fraction ≥ 99.5%, and place it in an ultrasonic extractor for extraction. The extraction temperature is 40° C., and the extraction time is 15 min. After the extraction, the extract is filtered to obtain the filtrate and the filter residue, the filtrate is concentrated and the solvent is recovered, and the filter residue is extracted again with the recovered solvent. The extraction temperature and time are the same as the first extraction. After the extraction, the extract is extracted. The filtrate and filter residue were obtained by filtration, the filtrate was concentrated and the s...

Embodiment 2-3

[0030] Extraction of resveratrol: On the basis of implementation case 1, change the process parameters such as extraction temperature (°C), extraction time (min), extraction times, solid-liquid ratio (g / ml), particle size, etc. The specific implementation parameters are as follows As shown in the table:

[0031]

[0032]

[0033] The purification parameters of resveratrol are: change the resin model, sample concentration, shaking temperature ℃, adsorption time, eluent volume fraction, elution time min, elution temperature ℃, as shown in the following table:

[0034]

[0035] In the above-mentioned Examples 2-3, the parameters for extracting the pigment from the filter residue after extracting resveratrol are: ethanol volume fraction, extraction temperature (°C), extraction time (min), extraction times, solid-liquid ratio (g / ml ), the specific implementation parameters are shown in the table below:

[0036] Example

Embodiment 4-7

[0038] Extraction of resveratrol: On the basis of the implementation of Case 2-3, other extraction conditions remain unchanged, only the extraction solvent is changed, and the specific implementation parameters are as follows:

[0039]

[0040]Pigment extraction: On the basis of the implementation of Case 2-3, other extraction conditions remain unchanged, and only the volume fraction of the extraction solvent is changed. The specific implementation parameters are as follows:

[0041]

[0042] The purification of the pigment in the above-mentioned Examples 2-7 is the same as in Example 1.

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Abstract

The invention relates to a technique for extracting effective ingredients from a natural product, particularly a technique for extracting resveratrol and pigment from grape skin, which comprises the following steps: drying the grape skin, pulverizing, extracting resveratrol by ultrasonic waves, extracting pigment by ultrasonic waves, and purifying to obtain the resveratrol product and the pigment product. In the technical scheme provided by the invention, double solvents and ultrasonic extraction are integrated; the technical scheme provided by the invention has the advantages of high extraction efficiency, low extraction cost and low energy consumption by using the ultrasonic extraction technique according to the principle that the resveratrol and pigment in the grape skin have different solubilities in solvents with different polarities; the solvents used in the extraction process can be utilized cyclically, so that the solvent consumption is low, and the environmental influence is low, thereby avoiding destroying the bioactivities of the resveratrol and the pigment in the extraction process; and thus, the invention is suitable for extracting bioactive substances.

Description

Technical field [0001] The invention relates to a process for extracting active ingredients from natural products, in particular to a process for extracting resveratrol and pigments from grape skins. Background technique [0002] Resveratrol has anti-oxidation, anti-aging, anti-cancer, hypolipidemic, beauty, weight loss and other effects; grape skin pigment is a natural pigment, which can be widely used in food industries such as jam and fruit wine. Compared with synthetic pigments, it has a certain Nutritional value and pharmacological effects; According to relevant statistics, resveratrol and grape skin pigments are in great demand in the international market, and have a very broad market prospect. Because the pigment and resveratrol contained in grape skin have poor high temperature resistance, instability and easy inactivation, they must be extracted under relatively mild conditions. [0003] At present, due to the increase of wine production, a large number of grape sk...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C39/21C07C37/72C09B61/00
Inventor 胡奇林王宏郭燕
Owner GANSU SHOULUSHAN PHARMA CO LTD
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