Preparation method of tripterine

A technology of tripterygium and tripterygium, applied in the field of natural medicinal chemistry, can solve the problems of small preparation amount and low degree of industrialization, and achieve the effects of low toxicity, high degree of industrialization and shortened production cycle

Inactive Publication Date: 2012-07-25
苏州宝泽堂医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented method uses ethylene glycol (EOG), an organic chemical called acetone that helps extract flavors from foods by breaking down certain molecules into smaller ones like water or carbon dioxide gas. It also reduces harmful side products such as formaldehyde during processing compared with traditional methods involving other solvents. Additionally, it allows for easier separation of impurities due to its ability to separate out these compounds easily at room temperature without losing their effectiveness over time. Overall, this technology makes better ways to produce tasteier beverages while reducing environmental impact.

Problems solved by technology

This patented technical problem addressed in this Patents describes how to efficiently produce triptorpinia (TTP) without causing harmful side effects such as inflammations caused by tissue damaging agents like nitrogen oxide gases released during chemotherapy treatments.

Method used

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  • Preparation method of tripterine

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Embodiment 1

[0025] The root of tripterygium twig is crushed, weighed 1kg, added 7 times the amount of 85% ethanol for reflux extraction for 1 hour, filtered the extract, added 5 times the amount of 85% ethanol solution for reflux extraction for 1 hour, combined the extract and added 100g of medicinal powdered activated carbon, 80 Decolorize at ℃ for 1 hour, filter out activated carbon, recover ethanol from the decolorization solution to an alcohol concentration of 55%, let it settle for 8 hours, filter out the precipitate, and obtain 32 g of precipitate, use 220ml of 70% ethanol solution (containing 0.4% sodium hydroxide), and stir thoroughly Dissolve, filter out the insoluble matter, adjust the pH to 3 with concentrated hydrochloric acid, place the precipitate, filter out the precipitate, then dissolve it with 100ml of 70% alcohol solution (containing 0.4% sodium hydroxide), filter to adjust the pH to neutral, place the precipitate, filter out the precipitate, and use acetic acid Ethyl es...

Embodiment 2

[0027] Pulverize the root of Tripterygium wilfordii, weigh 1kg, add 7 times the amount of 90% ethanol for reflux extraction for one hour, filter the extract, add 5 times the amount of 90% ethanol solution for reflux extraction for 1 hour, combine the extracts and add 150g of medicinal powdered activated carbon, 80 Decolorize at ℃ for 1 hour, filter out activated carbon, recover ethanol from the decolorized solution to an alcohol concentration of 65%, let it settle for 12 hours, filter out the precipitate to obtain 28 g of precipitate, use 140ml of 85% ethanol solution (containing 0.8% sodium hydroxide), and stir thoroughly Dissolve, filter out insoluble matter, adjust the pH to 5 with concentrated hydrochloric acid, place the precipitate, filter out the precipitate, then dissolve it with 80ml of 85% ethanol solution (containing 0.8% sodium hydroxide), filter to adjust the pH to neutral, place the precipitate, filter out the precipitate, and use acetic acid Ethyl ester was reflu...

Embodiment 3

[0029] Tripterygium twig root is pulverized, weighed 10kg, added 7 times the amount of 85% ethanol for reflux extraction for 1 hour, filtered the extract, added 5 times the amount of 85% ethanol solution for reflux extraction for 1 hour, combined the extract and added 1kg of medicinal powdered activated carbon, 80 Decolorize at ℃ for 1 hour, filter out activated carbon, reclaim ethanol from the decolorization solution to an alcohol concentration of 60%, place it for precipitation for 10 hours, filter out the precipitate, and obtain 306 g of precipitate, use 1.6L of 85% ethanol solution (containing 0.8% sodium hydroxide), fully Stir to dissolve, filter out insoluble matter, adjust pH3 with concentrated hydrochloric acid, place the precipitate, filter out the precipitate, then dissolve it with 1Lml85% ethanol solution (containing 0.8% sodium hydroxide), filter to adjust the pH to neutral place the precipitate, filter out the precipitate, and use Ethyl acetate is refluxed to disso...

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Abstract

The invention relates to a preparation method of tripterine, and the method comprises the following steps: crushing triperygium wilfordii roots, adding 5-7 times amount of 85-90% alcohol, refluxing for 2-3 times, and decolorizing the extracting solution by virtue of active carbon; recycling the alcohol from the destaining solution until the alcohol concentration is 55-65%, standing the destaining solution to precipitate, filtering out precipitates, dissolving the precipitates in 5-7 times amount of an alkaline alcohol solution, filtering out insolubles, adjusting the pH value of the filtered solution to 3-5, standing the solution to precipitate, filtering out precipitates, dissolving the precipitates in 3-5 times amount of the alkaline alcohol solution, filtering insolubles, adjusting the pH value of the filtered solution to 7, standing the solution to precipitate, filtering out precipitates, adding ethyl acetate into the precipitates to reflux and dissolve the precipitates, filtering the dissolvent solution, standing the filtered solution to crystallize, filtering out the crystal, adding 90-95% alcohol into the crystal, refluxing and dissolving the crystal, decolorizing the crystal alcohol solution by the active carbon, insulating and crystallizing the decolorized solution, finally drying the obtained crystal to obtain the tripterine pure product. The preparation method of the tripterine is convenient and simple, the impurity of the obtained product is high, the toxicity of used reagents is small, and the preparation method of the tripterine is suitable for industrial production.

Description

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Claims

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Application Information

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Owner 苏州宝泽堂医药科技有限公司
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