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Bupleurum antipyretic and analgesic preparation and technology for preparing same

An antipyretic and analgesic, Bupleurum chinensis technology, applied in the directions of non-central analgesics, antipyretics, anti-inflammatory agents, etc. The effect of improving pain effect, convenient application and ensuring stability

Active Publication Date: 2013-09-18
SICHUAN DE PEI YUAN TRADITIONAL CHINESE MEDICINE SCI & TECH DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The main purpose of the present invention is to provide a Bupleurum antipyretic and analgesic with remarkable antipyretic and analgesic effects and suitable for multiple drug routes in view of the problems of poor therapeutic effect and limited drug routes of Bupleurum preparations in the above-mentioned prior art. preparation

Method used

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  • Bupleurum antipyretic and analgesic preparation and technology for preparing same
  • Bupleurum antipyretic and analgesic preparation and technology for preparing same

Examples

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Effect test

Embodiment 1

[0042] What present embodiment enumerates is Radix Bupleuri granule 350g, and formula is as follows:

[0043] Active ingredients: Bupleurum volatile oil 3ml; saikosaponin 6g;

[0044]Pharmaceutical excipients: 30g of β-CD, 256g of sucrose, 64g of dextrin, appropriate amount of starch slurry.

[0045] Preparation Process:

[0046] (1) Take 1000g of Bupleurum medicinal material, crush it to 20-60 mesh, and extract the volatile oil of Bupleurum with carbon dioxide supercritical extraction equipment:

[0047] Put the pulverized Bupleuri herb into the extraction kettle, and then pump the supercritical medical grade carbon dioxide fluid through the purifier, cooling system and high-pressure pump into the extraction kettle at a flow rate of about 20kg / h. Extraction under the condition of 20MPa pressure for 1.5h; two-stage separation of the extract, the operating conditions of the separation tank I are: pressure 12MPa, temperature 40°C, the operating conditions of the separation tan...

Embodiment 2

[0052] What present embodiment enumerates is Bupleurum nose drops 1000ml, and formula is as follows:

[0053] Active ingredients: Bupleurum volatile oil 1ml; saikosaponin 10g;

[0054] Pharmaceutical excipients: HP-β-CD 30g, sodium chloride 9g.

[0055] Preparation Process:

[0056] (1) Take 1000g of Bupleuri herb, crush it to 20-60 mesh, add 10 times the amount of water, soak at 70°C for 8 hours, distill, and collect volatile oil, about 1ml;

[0057] (2) Take the medicinal residues of Bupleurum chinensis after supercritical extraction of volatile oil, add 65% (v / v) of 12 times the volume of the medicinal material, and soak in ethanol with a pH value of 8 for 24 hours, and perform percolation at a flow rate of 10mL / min. The percolate is concentrated under reduced pressure at 65°C to a concentrated solution with a relative density of 1.1 to 1.2;

[0058] Put the concentrated solution on a D101 macroporous resin column with a diameter-to-height ratio of 1:3 for static adsorpt...

Embodiment 3

[0063] What present embodiment enumerates is Bupleurum oral liquid 1000ml, and formula is as follows:

[0064] Active ingredients: Bupleurum volatile oil 4ml; saikosaponin 4g;

[0065] Pharmaceutical excipients: HP-β-CD 50g, aspartame 2g.

[0066] Preparation Process:

[0067] (1) Take 1000g of Bupleurum medicinal material, crush it to 20-60 mesh, and extract the volatile oil of Bupleurum with carbon dioxide supercritical extraction equipment: the extraction process is the same as in Example 1, wherein the flow rate of the supercritical medical grade carbon dioxide fluid is 20kg / h, The extraction conditions are: 35°C, 25MPa, and the extraction time is 1h. The operating conditions of the separation tank I are: the pressure is 12MPa, the temperature is 35°C, the operating conditions of the separation tank II are: the pressure is 6MPa, the temperature is 30°C; The supercritical product with Bupleurum volatile oil as the main component was collected at the outlet of the fraction...

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Abstract

The invention relates to the field of Chinese medicinal preparation, and particularly discloses a bupleurum antipyretic and analgesic preparation and a technology for preparing the same. The bupleurum antipyretic and analgesic preparation contains bupleurum essential oil, saikoside and pharmaceutical adjuvant, wherein the volume to weight ratio of the bupleurum essential oil and the saikoside is 1 / 0.5-10(ml / g). Preferably, the volume to weight ratio of the bupleurum essential oil and the saikoside is 1 / 1-6(ml / g). Meanwhile, the invention discloses a technology for preparing the bupleurum antipyretic and analgesic preparation. The bupleurum antipyretic and analgesic preparation provided in the invention has obvious antipyretic and analgesic effects, and has wide administration routes.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, in particular to a stable and efficient antipyretic and analgesic preparation of Bupleurum bupleuri and its preparation process. Background technique [0002] Bupleurum is a large number of commonly used traditional Chinese medicines. It is listed as the top grade in "Shen Nong’s Materia Medica". It is the dried root of Bupleurum chinense DC or Bupleurum scorzonerifolium Willd. It is an essential medicine for reconciling exterior and interior, soothing the liver, and promoting yang. Bupleurum is mainly used for the treatment of common cold and fever, alternating cold and heat, chest pain, irregular menstruation, uterine prolapse, anal prolapse and other diseases. Modern chemical research has found that the main chemical components of Bupleuri are volatile oil, saikosapoins (saikosapoins a, b, c, d), polysaccharides and flavonoids, etc. Fever caused by paratypho...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/233A61P29/00A61K125/00
Inventor 马家骅张翠鳌索志荣马璇杨兴旺
Owner SICHUAN DE PEI YUAN TRADITIONAL CHINESE MEDICINE SCI & TECH DEV CO LTD
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