Polygonatum compound granule and preparing method thereof

A technology of granules and sealwort, which is applied in the field of compound sealwort granules and its preparation, can solve the problems of large side effects, inability to prevent and control, easy rebound, etc.

Active Publication Date: 2012-09-19
张旺凡
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, although commonly used western medicines such as niacin, fibrate, and clofibrate lower blood lipids quickly and have strong antitropism, they are prone to rebound after drug withdrawal and have serious side effects.
At

Method used

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Examples

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Effect test

preparation example Construction

[0015] The present invention also provides a preparation method of the Polygonatum Compound Granules, comprising the following steps:

[0016] A. Chinese medicine extraction: extract Polygonatum, Salvia, Hawthorn, Ginkgo leaves, and Ganoderma lucidum respectively to obtain Polygonatum extract, Salvia extract, Hawthorn extract, Ginkgo extract, and Ganoderma lucidum extract;

[0017] B. Preparation of granules: After mixing Rhizoma Polygonatum extract, Salvia miltiorrhiza extract, Hawthorn extract, Ginkgo biloba extract, Ganoderma lucidum extract and pharmaceutical excipients in proportion, soften and granulate, and obtain the Polygonatum compound granule after drying.

[0018] Because the Chinese medicine raw material that the present invention adopts such as Polygonatum contains flavonoids and anthracene, the triterpenoids contained in Ganoderma lucidum, the lactone contained in Ginkgo biloba, etc., are only soluble in organic solvents and difficult to dissolve in water. Theref...

Embodiment 1

[0024] After cleaning the 30g sealwort, extract with 80wt% ethanol, and then use water to extract. The water extract and the ethanol extract were spray-dried together to obtain 2 grams of Polygonatum extract.

[0025] After washing 25g of Salvia miltiorrhiza, first extract with 80wt% ethanol, then extract with water, and dry the water extract and ethanol extract together by spraying to obtain 1 g of Salvia miltiorrhiza extract.

[0026] After cleaning 25g of hawthorn, extract it with 80wt% ethanol, then extract it with water, and dry the water extract and alcohol extract together by spraying to obtain 1 g of hawthorn extract.

[0027] After 9g of ginkgo leaves were cleaned, they were first extracted with 80wt% ethanol, then extracted with water, and the water extract and alcohol extract were dried together by spraying to obtain 0.5 g of ginkgo leaf extract.

[0028] After washing 10 g of Ganoderma lucidum, extract it with 80 wt % ethanol and then extract it with water, and dr...

Embodiment 2

[0031] Polygonatum compound granule S2 of this example is prepared by using the extracts of Polygonatum extract, Salvia miltiorrhiza extract, Hawthorn extract, Ginkgo biloba extract and Ganoderma lucidum extract extracted in proportion in Example 1, the difference is that 25% Polygonatum extract 14% salvia miltiorrhiza extract, 1.4% hawthorn extract, 6% ginkgo extract, 4% ganoderma lucidum extract, 25% pharmaceutical excipients, mixed evenly, softened, granulated, and dried to obtain the Polygonatum compound granule S2 of this embodiment .

[0032] Huangjing Compound Granules S1 and S2 have been tested in animal models and have the following effects:

[0033] (1) Lipid reduction: There were significant differences in total cholesterol, triglycerides, low-density lipoprotein and apolipoprotein A.

[0034] (2) Hypoglycemic: Glucose oxidase method was used to measure the blood glucose value, the model group was 9.39±1.45, and the treatment group was 8.16±1.59, and the P value be...

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PUM

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Abstract

The invention provides a polygonatum compound granule which comprises the following components in percent by weight: 25 to 28% of polygonatum extract, 14 to 20% of salvia extract, 14 to 20% of hawthorn extract, 6 to 7% of ginkgo extract, 4 to 7% of ucidum extract and 25 to 30% of pharmaceutical auxiliary material. The invention further provides a preparing method of the polygonatum compound granule. On one hand, the polygonatum compound granule, provided by the invention, adopts extracts of traditional Chinese medicine with five flavours having lipid-lowering, blood sugar reducing and anti-aging effects, and the content of efficient compositions in the traditional Chinese medicine is higher, one the other hand, through proper selection of the content of the extracts of the traditional Chinese medicine, each of the traditional Chinese medicine can serve as a supplement to one another; and in addition, the polygonatum compound granule provided by the invention can ensure dosage when being taken, is easy to store, and has low possibility of deterioration.

Description

technical field [0001] The invention belongs to the technical field of health-care medicines, and in particular relates to a Polygonatum compound granule and a preparation method thereof. [0002] Background technique [0003] Along with the development of social economy, people's living standard improves day by day, and dining table is richer day by day. Because most people do not know how to eat scientifically, it will lead to nutritional imbalance, qi and blood imbalance, endocrine disorders, and decreased immunity in the long run, and various diseases will take advantage of it. In addition, there are currently 120 million people over the age of 60 in my country, and by 2020, people aged 65 and over will account for more than 20% of the total population. With the aging of the population, the acceleration of urbanization and industrialization, and the serious environmental pollution, cardiovascular and cerebrovascular diseases, metabolic diseases and tumors that affect p...

Claims

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Application Information

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IPC IPC(8): A61K36/8969A61K9/16A61P39/06A61P3/06A61P3/10A61P9/12A61P9/00A23L1/29A23L33/00
Inventor 张旺凡
Owner 张旺凡
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