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Quality detection method of gingerol type extract

A quality inspection method and extract technology, which can be used in measurement devices, color/spectral property measurement, instruments, etc., and can solve problems such as differences in drug efficacy

Inactive Publication Date: 2012-09-19
GUILIN SANJIN PHARMACEUTICALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The soft capsule preparation prepared with gingerol extract is an ideal dosage form. However, since gingerol extract is prepared as a traditional Chinese medicine extract, ginger extract prepared by different separation and extraction methods will have great differences in composition. Thereby cause the difference of drug curative effect, in order to further standardize the quality method of gingerol class extract soft capsule preparation, propose the present invention especially

Method used

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  • Quality detection method of gingerol type extract
  • Quality detection method of gingerol type extract
  • Quality detection method of gingerol type extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0117] (1) Preparation of Gingerol Extract Soft Capsules:

[0118] Recipe: 3 grams of gingerol extract, 27 grams of corn oil, made into 100 capsules;

[0119] Preparation:

[0120] 1. Supercritical carbon dioxide extraction of gingerols extract:

[0121] (1) Cut the ginger into thin slices of 2-5mm, ventilate and dry at 45°C until the water content is less than 10%, crush it through a 40-mesh sieve to obtain ginger powder;

[0122] (2) Fill ginger powder into supercritical CO 2 In the extraction device, at a temperature of 55°C, a pressure of 30Mpa, CO 2 Flow rate is to extract under the condition of 10kg / h.kg raw material, and extraction time is 2 hours, then in the separation tank that pressure is 10Mpa, collect and obtain gingerols extract, its high performance liquid chromatogram is as follows figure 1 shown.

[0123] 2. Solution preparation

[0124] Preparation of the content solution: Accurately weigh 600g of gingerol extract, add 5400g of medicinal corn oil, stir ...

Embodiment 2

[0232] Embodiment 2: the detection of gingerols extract

[0233] The method in Example 1 was used to prepare the ginger phenolic extract, and the semi-solid effective part extracted from ginger with supercritical carbon dioxide had a main component of phenolic compounds. Take 3 batches for testing: 011108, 011109, 011110.

[0234] 【Solubility Test】

[0235] According to the Chinese Pharmacopoeia 2010 edition, it is measured under a general rule item.

[0236] Table 15: Solubility test results of raw materials

[0237] solvent

[0238] It can be seen from the above results that this product is very soluble in ethanol, ethyl acetate and ether, but insoluble in water.

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Abstract

The invention relates to a quality detection method of a gingerol type extract and soft capsules thereof. The quality detection method specifically comprises trait inspection, identification, content determination and the like, wherein the content determination comprises the determination of total phenols and the determination of 6-gingerol, the determination of the total phenols adopts ultraviolet spectrophotometry, and the determination of the 6-gingerol adopts high performance liquid chromatography. According to the quality detection method disclosed by the invention, by improving the content determination method, the production quality level of an enterprise can be ensured, and the efficacy can be ensured.

Description

technical field [0001] The invention relates to a quality detection method of gingerols extract and soft capsules thereof. Background technique [0002] The rapid development of modern means of transportation and aerospace has played an important role in promoting human economic, cultural and social life, but at the same time, it also caused some people to suffer from motion sickness. Motion sickness is a nervous system dysfunction caused by unaccustomed conditions in the exercise environment, mainly manifested as autonomic nervous system dysfunction. Symptoms usually develop progressively, ranging from stomach discomfort, nausea, increased salivation, pale complexion, cold sweats, dizziness, headache, to retching, vomiting, lethargy, and apathy. Those with severe vomiting may even become dehydrated and exhausted. It occurs when people ride in cars, boats, airplanes, amusement rides or when nautical, aviation, spaceflight simulations and actual operations. [0003] Accord...

Claims

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Application Information

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IPC IPC(8): G01N30/90G01N30/02G01N21/33
Inventor 董俊兴邹节明
Owner GUILIN SANJIN PHARMACEUTICALS CO LTD
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