D-amino-acid oxidase inhibitor for preventing and/or reversing opioid tolerance
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- 王永祥
- Publication Date
- 2012-10-17
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
Technical field
[0001]
[01] The present disclosure relates to the prevention and / or reversal of opioid tolerance. Specifically, D-amino acid oxidase inhibitors for preventing and / or reversing opioid tolerance are provided, and methods of using D-amino acid oxidase inhibitors to prevent and / or reversing opioid tolerance are also provided. D-amino acid oxidase is used to prevent and / or treat pain, and to identify compounds that prevent and / or reverse opioid tolerance. Background technique
[0002]
[02] Opioid receptor agonists (also known as opioid agonists, opioids, opioids and opioids) such as morphine are a class of narcotic analgesics, when relatively high doses or low doses but long-term repeated use At times, strong drug tolerance is produced, which leads to a decrease in the analgesic effect of analgesics. Therefore, narcotic analgesics should be used in increased doses in order to obtain the desired analgesic effect. The increase in the dose of this narcotic analgesic ca...