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Novel lung cancer molecular marker retinoic acid receptor response protein 2

A technology of liver cancer cells and drugs, which is applied to the application field of retinoic acid receptor response protein 2 and its C-terminal active fragment in cancer prevention and treatment, can solve the problem that the role and mechanism are rarely reported.

Active Publication Date: 2015-04-22
SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although chemerin has been studied and reported in the fields of immunity, cardiovascular disease, and metabolic disease, there are few reports on its role and mechanism in tumors

Method used

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  • Novel lung cancer molecular marker retinoic acid receptor response protein 2
  • Novel lung cancer molecular marker retinoic acid receptor response protein 2
  • Novel lung cancer molecular marker retinoic acid receptor response protein 2

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Experimental program
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Embodiment Construction

[0052] The chemerin used in the present invention includes the polypeptide containing the amino acid sequence shown in SEQ ID NO: 2 (the 1st to 20th positions are signal peptides) and its active fragments retaining the biological activity of chemerin.

[0053] The chemerin of the present invention also includes a variant form of the sequence of SEQ ID NO: 2 that has the same function as the chemerin protein. These variations include (but are not limited to): several (usually 1-50, preferably 1-30, more preferably 1-20, optimally 1-10, and more preferably 1 - 8, 1-5) amino acid deletions, insertions and / or substitutions, and addition of one or several (usually within 20, preferably within 10, more at the C-terminal and / or N-terminal Preferably within 5) amino acids. For example, in the art, substitutions with amino acids with similar or similar properties generally do not change the function of the protein. As another example, adding one or several amino acids at the C-termin...

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Abstract

The present invention discloses a novel biomarker of HCC, RARRES2, and more specifically discloses a polypeptide with anticancer activity, comprising sequence of YFPGQFAFS or its variant. The invention also provides the use of the polypeptide in preparing the medication for treating and preventing caner, in preparing the medication for inhibiting Akt signal pathway. The invention also discloses a detecting kit for cancer prognosis, assessing the survival time of cancer patients through detecting the expression level of RARRES2 in a sample from the object.

Description

technical field [0001] The invention relates to the field of cancer prevention and treatment, in particular to the application of retinoic acid receptor response protein 2 and its C-terminal active fragment in cancer prevention and treatment. Background technique [0002] Hepatocellular carcinoma (hepatocellular carcinoma, HCC) is one of the most common and most harmful cancers in the world, ranking the fifth most common cancer in the world, and the third most common cause of cancer-related death, second only to lung cancer and gastric cancer. Liver cancer cells grow extremely actively, are highly invasive, and easily invade the capsule and blood vessels. Because there are abundant sinusoids in the liver, intrahepatic metastasis is the most common, and most patients have intrahepatic metastasis in the early stage. Liver cancer cells invade portal vein branches to form tumor thrombi, and liver cancer with portal vein tumor thrombi is considered to be one of the main indicator...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/08C12Q1/68G01N33/574A61P35/00A61P35/04
CPCC07K14/4702G01N33/57438A61K38/08A61P35/00A61P35/04
Inventor 谢东李晶晶印宏坤刘将
Owner SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI