Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of vitamin C micro-pill

A technology of vitamins and micro-pills, which is applied in the direction of bulk delivery, metabolic diseases, oil/fat/wax non-active ingredients, etc., and can solve problems such as discoloration when exposed to light, affecting product quality stability, and unstable properties of vitamin C.

Inactive Publication Date: 2012-12-19
GUANGXI JINHAITANG PHARMA
View PDF1 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Vitamin C is unstable in nature, changes color when exposed to light, and is easily oxidized and decomposed when exposed to heat or moisture, resulting in a decrease in content, which is the main reason affecting the stability of product quality
Traditionally, vitamin C raw materials

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0014] A kind of preparation method of vitamin C pellet of the present invention, its concrete operation is as follows:

[0015] 1. Preparation of ball core: put the vitamin C raw material into the mixer, use dextrin as the binder, citric acid as the antioxidant, use ethanol as the wetting agent, and add 3-7% dextrin of the quality of the vitamin C raw material , 3-7% microcrystalline cellulose, 0.5-1.5% citric acid, and then add 10-20% ethanol (volume concentration 95%) of the total mass of the above materials, mix for 15-20 minutes, and use a rocking particle mechanism Into a ball core.

[0016] 2. Prepare coating solution:

[0017] Take the following raw materials according to the mass percentage of vitamin C raw materials: 0.36% No. Ⅱ enteric acrylic resin, 9% ethanol (volume concentration is 95%), 0.03% castor oil, and 0.03% Tween-80.

[0018] Preparation method: Add No. Ⅱ enteric-coated acrylic resin into ethanol, swell for 24 hours, stir evenly, then add castor oil an...

Embodiment 1

[0023] 1. Preparation of pellet core: Put 100kg of vitamin C raw material into a mixer, add 3kg of dextrin, 7kg of microcrystalline cellulose, and 0.5kg of citric acid, then add 11kg of ethanol with a volume concentration of 95%, mix for 15 minutes, and use The swinging granulator makes pellet cores that can pass through a 24-mesh sieve.

[0024] 2. Preparation of coating solution: Weigh 0.36 kg of No. Ⅱ enteric acrylic resin, add 9 kg of ethanol with a volume concentration of 95%, swell for 24 hours, and stir evenly; then add 0.03 kg of castor oil and 0.03 kg of Tween-80, Stir evenly to obtain the coating solution;

[0025] 3. Coating of pellet cores: Put the pellet cores into a fluidized coating machine and heat up to 38°C, then spray coating solution for dynamic coating. During coating, the material temperature is controlled at 45°C, and the spraying time is 160 minutes, after the end, the temperature is controlled at 45°C and dried to a moisture content of 2%, and after t...

Embodiment 2

[0028] 1. Preparation of ball core: Put 100kg of vitamin C raw material into the mixer, add 5kg of dextrin, 5kg of microcrystalline cellulose, and 1kg of citric acid, then add 15kg of ethanol with a volume concentration of 95%, mix for 18 minutes, and use a swing The granulator makes ball cores that can pass through a 24-mesh sieve.

[0029] 2. Preparation of coating solution: Weigh 0.36 kg of No. Ⅱ enteric-coated acrylic resin, add 9 kg of ethanol with a volume concentration of 95%, swell for 24 hours, and stir evenly; then add 0.03 kg of castor oil and 0.03 kg of Tween-80, and stir Evenly, the coating solution is obtained;

[0030] 3. Coating of pellet cores: Put the pellet cores into a fluidized coating machine and heat up to 40°C, then spray coating solution for dynamic coating. During coating, the material temperature is controlled at 45°C, and the spraying time is 170 minutes, after the end, the temperature is controlled at 50°C and dried to a moisture content of 2.5%, ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation method of a vitamin C micro-pill, comprising the following process steps: taking auxiliary materials including dextrin, microcrystalline cellulose, citric acid and the like to prepare a vitamin C pill core; taking No. II enteric acrylic resin as a coating material, wherein the concentrating of a coating solution is 4%; and carrying out dynamic coating under the condition that the temperature is 40-50 DEG C to prepare the vitamin C micro-pill with better stability. According to the vitamin C micro-pill prepared by the method disclosed by the invention, the surface of the vitamin C micro-pill is covered so that a formed coating has very good blocking effects on oxygen and water, so as to have a very good protection effect on easily-oxidized vitamin C and improve the stability; and the fineness distribution of the micro-pill is reasonable and the mobility is good, so as to be good for mixing the micro-pill with other auxiliary materials or medicines to carry out preparation production in the next step.

Description

technical field [0001] The invention relates to a preparation process, in particular to a preparation process of vitamin C pellets. Background technique [0002] Vitamin C is unstable in nature, changes color when exposed to light, and is easily oxidized and decomposed when exposed to heat or moisture, resulting in a decrease in content, which is the main reason affecting the stability of product quality. Traditionally, vitamin C raw materials are directly used in the production of preparations without any treatment, resulting in a decrease in vitamin C content and unstable quality; or adding antioxidants such as tartaric acid and citric acid to prevent the oxidative decomposition of vitamin C, but the effect is not good. ideal. Contents of the invention [0003] The technical problem to be solved by the present invention is to provide a preparation process with simple process, low cost and capable of effectively improving the quality stability of vitamin C. [0004] The...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/16A61K31/375A61K47/44A61P3/02
Inventor 邓福胜马健雄张平吉罗宇韩博研
Owner GUANGXI JINHAITANG PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com