Preparation technique of vitamin C fat powder coating

A technology of powder coating and preparation process, which is applied in powder conveying, animal feed molding or processing, medical preparations containing active ingredients, etc. The effect of good performance and reasonable particle size distribution

Inactive Publication Date: 2009-04-01
DSM JIANGSHAN PHARMACEUTICAL (JIANGSU) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For this reason, it is particularly important to coat its surface with a layer of light-proof, heat-insulating, air-proof and water-insoluble protective layer. At present, among many pharmaceutical dosage forms, coating is mainly used for tablets, pills, Capsules, powder coating is rarely mentioned, and there is no disclosure of powder coating preparation technology about vitamin C in the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Taking the fat coating with a content of 90% as an example, using vitamin C sieved under 20 meshes as raw material, the weight ratio of hydrogenated vegetable oil, acrylic resin No. II and tartaric acid is 7.9:2:0.1, using isopropanol as solvent, hydrogenated vegetable oil , Acrylic resin No. II and tartaric acid are made into a 23.3% coating solution. Specifically, first add 2.0% acrylic resin No. II and 0.1% tartaric acid crystals into a hot and cold cylinder filled with isopropanol, turn on the stirring anchor to heat up and dissolve it, and after the acrylic resin No. II is dissolved, add 7.9% hydrogenated Vegetable oil is warmed to above 55°C to allow it to melt and keep warm for spray coating.

[0015] For varieties with different content, the content of clothing material is adjusted in proportion, and the amount of solvent is adjusted in proportion to the amount of feed.

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PUM

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Abstract

The invention discloses a technology for preparing a vitamin C fat powder coating. In the technology, the raw material vitamin C is put in a fluidizing coating machine to be fluidized and preheated; according to the feeding quantity, regulated coating solution is weighed for spray dynamic coating; the temperature of the material is controlled between 30 DEG C and 50 DEG C during spray coating; the temperature is controlled between 50 DEG C and 55 DEG C after the spray coating; isopropanol is removed from the coating solution which is then cooled to 38 DEG C after drying, and the material is put out to be filtered by a 20-mesh sieve; and then the material is mixed uniformly in a mixer. The technology increases the stability of vitamin C and controls the dissolution and release speeds of the vitamin C in water or under high temperature; and the vitamin C fat powder coating has reasonable fineness distribution of particle and good fluidity and can be distributed completely and uniformly when mixed with other auxiliary material or drug.

Description

technical field [0001] The invention relates to the technical field of vitamin production, in particular to a preparation process for vitamin C fat powder coating. Background technique [0002] Vitamin C has a wide range of uses in medical food and feed, but it exists as an antioxidant, and it often becomes the first oxidized object to be sacrificed, especially in the medium where metal ions such as iron and copper exist. , heat, water, oxygen, and oxidizing agents are easily oxidized. For example, as feed for fish, shrimp, and livestock, it is easy to dissolve when encountering high temperature and splashing in water during post-processing, and loses a lot of its own medicinal effect. For this reason, it is particularly important to coat its surface with a layer of light-proof, heat-insulating, air-proof and water-insoluble protective layer. At present, among many pharmaceutical dosage forms, coating is mainly used for tablets, pills, Capsules and powder coating are rarely...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/14A61K31/365A23K1/16A23K20/158A23K20/174A23K40/10A23K40/30A23K50/80
CPCY02A40/818
Inventor 陆斌倪国成龚卫兵王健
Owner DSM JIANGSHAN PHARMACEUTICAL (JIANGSU) CO LTD
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