Preparation and application of glucan gel surface Sudan red molecularly-imprinted adsorption material

A glucan gel, molecular imprinting technology, applied in other chemical processes, chemical instruments and methods, etc., can solve the problems of destroying the imprinting point and poor controllability, and achieve strong adsorption capacity, low production cost, and excellent mechanical stability. sexual effect

Inactive Publication Date: 2012-12-19
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method requires a simple device and strong universality, but there are usually the following problems: (1) The controllability is poor during the grinding process, and some irregular particles are inevitably generated, and some imprinted spots are destroyed at the same time.
However, there are no published patents and literature reports on the synthesis of Sudan Red molecularly imprinted adsorption materials using Sephadex as a support.

Method used

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  • Preparation and application of glucan gel surface Sudan red molecularly-imprinted adsorption material
  • Preparation and application of glucan gel surface Sudan red molecularly-imprinted adsorption material
  • Preparation and application of glucan gel surface Sudan red molecularly-imprinted adsorption material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) Dextran gel activation treatment: pre-swelled and washed dextran gel several times in 6mol / L hydrochloric acid solution, soaked at room temperature for 24 hours, washed with deionized water until neutral, and dried at 80°C after suction filtration , to obtain activated dextran gel;

[0027] (2) Preparation method of mercaptodextran gel, add 20mL thioglycolic acid, 20mL tetrahydrofuran, 10g activated dextran gel into a four-neck flask, add 0.1mL concentrated sulfuric acid, stopper, heat the solution at 40°C, and react under stirring After 48 hours, cool to room temperature and filter, then wash with deionized water until the filtrate is neutral, wash with a small amount of acetone, and dry in an oven at 40±2°C to obtain mercaptodextran gel;

[0028] (3) Preparation of Sudan Red molecularly imprinted adsorption material on the surface of dextran gel: Add 20mL of acetonitrile into a four-neck flask, add 0.05g of Sudan Red, stir and fully dissolve at room temperature, t...

Embodiment 2

[0031] (1) Dextran gel activation treatment: pre-swelled and washed dextran gel several times in 6mol / L hydrochloric acid solution, soaked at room temperature for 24 hours, washed with deionized water until neutral, and dried at 80°C after suction filtration , to obtain activated dextran gel;

[0032](2) Preparation method of mercaptodextran gel, add 15mL thioglycolic acid, 12mL tetrahydrofuran, 10g activated dextran gel into a four-neck flask, add 0.1mL concentrated sulfuric acid, stopper, heat the solution at 40°C, and react under stirring After 55 hours, cool to room temperature and filter, then wash with deionized water until the filtrate is neutral, wash with a small amount of acetone, and dry in an oven at 40±2°C to obtain mercaptodextran gel;

[0033] (3) Preparation of Sudan Red molecularly imprinted adsorption material on the surface of dextran gel: Add 30 mL of acetonitrile into a four-neck flask, add 0.1 g of Sudan Red, stir and fully dissolve at room temperature, t...

Embodiment 3

[0036] (1) Dextran gel activation treatment: pre-swelled and washed dextran gel several times in 6mol / L hydrochloric acid solution, soaked at room temperature for 24 hours, washed with deionized water until neutral, and dried at 80°C after suction filtration , to obtain activated dextran gel;

[0037] (2) Preparation method of mercaptodextran gel, add 12mL thioglycolic acid, 15mL tetrahydrofuran, 8.0g activated dextran gel into a four-neck flask, add 0.1mL concentrated sulfuric acid, stopper, heat the solution at a constant temperature of 40°C, and stir React for 60 hours, cool to room temperature and filter, then wash with deionized water until the filtrate is neutral, wash with a small amount of acetone, and dry in an oven at 40±2°C to obtain mercaptodextran gel;

[0038] (3) Preparation of Sudan Red molecularly imprinted adsorption material on the surface of dextran gel: Add 40 mL of acetonitrile into a four-neck flask, add 0.2 g of Sudan Red, stir and fully dissolve at roo...

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Abstract

The invention discloses a preparation method of glucan gel surface Sudan red molecularly-imprinted adsorption material, and the application of the glucan gel surface Sudan red molecularly-imprinted adsorption material in selective adsorption and separation of Sudan red molecules in food analysis. The method takes glucan gel as a supporter, and Sudan red molecularly-imprinted polymer is modified on the surface of the supporter. The preparation method is mainly and technically characterized by comprising the steps of: adding Sudan red, ethylene glycol dimethacrylate, azodiisobutyronitrile and sulfydryl glucan gel according to a certain proportion; in acetonitrile medium, removing oxygen by inert gas, carrying out reaction at the constant temperature, filtering and washing; carrying out Soxhlet extraction for 8-12h by 0.4-0.8mol / L of hydrochloric acid-ethanol solution to remove Sudan red template molecules; and finally, washing and drying to obtain the glucan gel surface Sudan red molecularly-imprinted adsorption material. The material has specific recognition capability on the Sudan red molecules, is high in selectivity, rapid in adsorption speed, good in desorption performance, biodegradable and simple in technology, has regeneration capacity and has the advantages of being environment-friendly and the like.

Description

technical field [0001] The invention relates to a preparation method and application technology of a molecularly imprinted adsorption material, in particular to a preparation method of a sudan red molecularly imprinted adsorption material on the surface of a dextran gel and its application technology in food testing. Background technique [0002] Sudan red dye is often used as an industrial raw material and is widely used in the color enhancement of solvents, oils, waxes, gasoline, shoes, and floors. In 1896, the scientist Duddy named it Sudan Red and it is still in use today. Sudan Red mainly includes four types of azo oil-soluble industrial pigments including I, II, III and IV. Among them, Sudan Red II, III and IV are all derivatives of Sudan Red I, which are listed by the International Agency for Research on Cancer (IARC) as One of the three carcinogens. All countries in the world have banned the use of Sudan Red in food; and driven by economic interests, some people us...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F251/00C08F222/14C08B37/02C08J9/26B01J20/26B01J20/30B01J20/285
Inventor 李慧芝许崇娟卢燕杨春霞贾欣峰
Owner UNIV OF JINAN
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